Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020473 (
hyperlipidemia
)
15,891
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neuromedin U
(
NMU
) is a hypothalamic neuropeptide that regulates body weight and composition. Here we show that mice lacking the gene encoding
NMU
(Nmu(-/-) mice) develop obesity. Nmu(-/-) mice showed increased body weight and adiposity, hyperphagia, and decreased locomotor activity and energy expenditure. Obese Nmu(-/-) mice developed hyperleptinemia, hyperinsulinemia, late-onset hyperglycemia and
hyperlipidemia
. Notably, however, treatment with exogenous leptin was effective in reducing body weight in obese Nmu(-/-) mice. In addition, central leptin administration did not affect
NMU
gene expression in the hypothalamus of rats. These results indicate that
NMU
plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin signaling pathway. These characteristic functions of
NMU
may provide new insight for understanding the pathophysiological basis of obesity.
...
PMID:Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. 1544 84
