Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hyperlipidaemia is a characteristic feature not only of the nephrotic syndrome but also of chronic renal disease without the features of that syndrome. There is evidence for disordered lipid metabolism in patients with chronic renal disease. In these patients the disordered lipid metabolism, the precise cause of which is unknown, is characterised by hypertriglyceridaemia, the aetiology of which is probably multifactorial. Hyperlipidaemia is an important potential risk factor in the aetiology of cardiovascular disease, which may be a leading cause of death in patients undergoing long-term maintenance haemodialysis therapy.
 ...
PMID:Disorders of blood-lipids in renal disease. 4 91

In contrast to previous reports, most patients (78%) with a successful renal transplant being followed up at the University of Kentucky Medical Center had a normal serum-lipid profile. The patients with hyperlipidaema (22%) had normal fasting insulin levels; they received similar immunosuppressive therapy but were significantly older and more obese than those with normal lipids. This lower prevalence of hyperlipidaemia and the absence of fasting hyperinsulinaemia are tentatively attributed to the use of alternate-day corticosteroid therapy in stable renal-transplant patients. If confirmed, the relative infrequency of hyperlipidaemia in patients of alternate-day corticosteroid therapy would be an additional advantage of that therapy over a daily regimen.
 ...
PMID:Normal serum-lipids in renal-transplant patients. 4 46

Serum-lipid concentrations and their relationship to blood-glucose and serum-insulin were examined in non-insulin-requiring diabetics, 62 with and 45 without retinopathy. The age, sex-body-weight, and duration of known diabetes was comparable in the two groups. All were treated by diet only or diet and oral hypoglycaemic agents. Patients with retinopathy had higher fasting serumtriglyceride and serum--cholesterol levels than those without. Compared with a non-diabetic population, significantly more diabetics with retinopathy had raised derum-lipids. The lipid concentrations did not correlate with body-weight, serum-thyroid-stimulating-hormone levels, renal involvement, or fasting blood-sugar. While the blood-sugar concentrations were similiar in the two groups the absolute insulin increment and the relative insulin response to a 50 g. oral glucose load were significantly lower in those with retinopathy than in those without. The impairment of insulin response correlated significantly with the frequency of hyperlipidaemia. It is suggested that insulin deficiency with secondary hyperlipidaemia is characteristic of diabetic patients with retinopathy.
 ...
PMID:Plasma-lipids and glucose/insulin relationship in non-insulin-requiring diabetics with and without retinopathy. 4 69

Twenty men with mild to moderate type-IV hypertriglyceridaemia were compared with normal men of the same age in the Busselton population survey. The type-IV men were not heavier but they were 3-2 cm. shorter and relatively hyperuricaemic. When gives a reducing diet, mean weight declined from 76-8 kg. to 68-7 kg. over 4-4 months and was kept steady over the next 10 months at 67-6 kg. Before, immediately after, and in the 10 months after weight reduction serum-triglycerides were 273, 112, and 126 mg. per 100 ml. and serum-cholesterol was 245, 227, and 226 mg. per 100 ml., respectively. On entry the mean daily calorie intake was 3165 and the contribution of the various nutrients were characteristic of the Australian diet. At lower weight, daily caloric intake was 2335. Protein intake was unchanged, but intake of fat and especially carbohydrate declined significantly. The findings support the view that type-IV hyperlipidaemia is the expression of a metabolic defect brought to light by weight-gain after maturity. In susceptible subjects "normal" weight-gain may be sufficient to induce hyperlipidaemia. Since type-IV and type-IIb hypertriglyceridaemias appear to increase the risk of coronary heart-disease, it is concluded that ideally no weight should be gained after reaching maturity. Avoidance of weight-gain should materially reduce the incidence of coronary disease in affluent western communities. Reduction to truly ideal weight gives much more impressive therapeutic results than drug therapy.
 ...
PMID:Type-IV hyperlipidaemia and weight-gain after maturity. 5 42

Muscle weakness and tenderness together with a rise in serum creatine kinase (C.K.) were noted in five uraemic patients treated with 1-2 g of clofibrate ('Atromid-S') daily. Excessive accumulation of both total and free serum chlorophenoxyisobutyric acid (C.P.I.B.), the active circulating metabolite after clofibrate therapy, was found in three patients in whom it was sought. It is suggested that chronic renal failure should be regarded as a contraindication to the use of clofibrate for the treatment of any coexisting hyperlipidaemia. If such therapy is contemplated it must be cautiously instituted at low dosage and the patient monitored by regular assessment of serum C.K. and levels of both total and free C.P.I.B.
 ...
PMID:Clofibrate-induced muscle damage in patients with chronic renal failure. 5

Among New Zealand adolescents, Maoris have lower serum high-density-lipoprotein cholesterol levels and higher serum triglyceride levels than non-Maoris. Boys have lower high-density-lipoprotein cholesterol and triglyceride levels than girls. Low-density-lipoprotein cholesterol levels do not show sex/race differences. These findings are reflected in an excess of hyperlipidaemia type IV in Maori girls. There may be a relation between these lipid distributions and the excess Maori mortality, especially among females, from ischaemic heart-disease.
 ...
PMID:High-density-lipoprotein cholesterol and other serum lipids in a New Zealand biracial adolescent sample. The Wairoa College survey. 6 65

Mean plasma cholesterol and triglyceride concentrations were measured in White female users and non-users of oral contraceptives and oestrogens in 10 diverse, demographically defined North American populations. About 50% of the younger women (20-24 years old) were taking oral contraceptives. In these women mean triglyceride concentrations were up to 48% higher and mean cholesterol concentrations were about 5% higher than in non-users. The 95% percentile of the total lipid distribution among non-users was used to define hyperlipidaemia. In young women on oral contraceptives hypercholesterolaemia was up to three times more common and hypertriglyceridaemia was up to five times more common than in non-users. 37% of older women (50-54 years) (presumably intramenopausal and postmenopausal) were hormone users, and in this group there were small, inconsistent alterations in plasma-triglyceride and a modest but consistent reduction in mean cholesterol concentration.
 ...
PMID:Altered plasma-lipids associated with oral contraceptive or oestrogen consumption. The Lipid Research Clinic Program. 6 1

After enteral administration of 200 mg/kg alpha-hexachlorocyclohexane (alpha-HCH) female Wistar rats develop a hyperlipemia. 48 h after administration of alpha-HCH, serum triglycerides are increased by 300%, whereas both serum cholesterol and serum total phospholipids only increase by about 45%. Serum free fatty acids are not significantly altered. Fractionation of the serum lipoproteins by ultracentrifugation shows that the hyperlipemia is due to a fivefold increase in serum very low density lipoproteins. Hepatic triglyceride secretion, calculated after i.v. injection of Triton WR 1339, is increased in animals pretreated wtih alpha-HCH. Corresponding to this observation, drugs known to diminish the triglyceride secretion of the liver, such as actinomycin D, cycloheximide; glucagon, orotic acid, CFT 1201, and CFT 1042 reduce the alpha-HCH-induced hyperlipemia. We concluded from the results that hyperlipoproteinemia after alpha-HCH is due to an increased hepatic very low density lipoprotein secretion. At the same time, the blood sugar level was decreased in fasting animals after treatment with alpha-HCH. Earlier experiments suggest that this effect is due to a decreased gluconeogenesis in the liver.
 ...
PMID:Increase of serum very low density lipoproteins in rats after administration of alpha-hexachlorocyclohexane. 6 95

Detected using a method involving gradient electrophoresis on polyacrylamide gel, the presence of a high level of an Lp(a) was demonstrated in 17% of control subjects and 39% oh hyperlipidaemic subjects explored. The difference appeared to be particularly significant in subjects with a pure hypercholesterolaemia (type IIA) or dominant hypercholesterolaemia (type IIB), which may be accounted for by the antigenic communities and related substances in the lipid composition uniting Lp(a) to LDL. The association of frank atherosclerosis with the hyperlipidaemia substantially increased the frequency of high levels of circulating Lp(a). A combined elevation of levels of Lp(a) and LDL would seem to be associated with a particular atherogenic power.
 ...
PMID:[Detection of a new lipoprotein: Lp(a). Its occurrence in atherosclerosis with or without hyperlipemia]. 7 59

The following topics are discussed in this presentation: A. Recent advances in the use and interpretation and methodology of antibiotic susceptibility testing. B. Improvements in sample submittal to obtain accurate results from your laboratory. C. Staining blood, bone marrow, and cytology specimens in the office laboratory. D. Pathogenesis and differential diagnosis of lipemia. E. Differential diagnosis of abdominal effusions.
 ...
PMID:Special topics in clinical pathology. 7 83


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>