Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a retrospective survey of patients taking medication for hyperlipidaemia, those taking niacin (nicotinic acid) were more likely (p < 0.05) to report sicca syndromes, blurred vision, eyelid oedema, and macular oedema compared with those who never took niacin. Additionally, 7% of those taking niacin discontinued the drug owing to adverse ocular side effects, while none of the other lipid lowering agents were found to cause these side effects (p = 0.016). Data from spontaneous reporting systems support a possible association of decreased vision, cystoid macular oedema, sicca-like symptoms, discoloration of the eyelids with or without periorbital or eyelid oedema, proptosis, loss of eyebrow or eyelashes, and superficial punctate keratitis with the use of niacin in high doses. Decreased vision may be marked, and if the drug is not discontinued, may progress to cystoid macular oedema. All ocular side effects listed above are reversible if the association with niacin is recognised and the drug is discontinued; both the incidence and severity of the ocular side effects seem to be dose dependent.
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PMID:Adverse ocular effects associated with niacin therapy. 788 Jul 95

We report the imaging features of a rare case of xanthoma in the floor of the anterior cranial fossa involving the frontal bone and orbit. A 42-year-old man presented with a history of proptosis, headache, and hyperlipidemia. Computed tomography demonstrated a well-circumscribed, homogenous, expansive mass with isodensity to brain parenchyma. On magnetic resonance imaging, the tumor showed high signal intensity relative to brain white matter on T1-weighted images, with heterogeneously high signal intensity on T2-weighted images. Histological examination established a diagnosis of xanthoma.
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PMID:CT and MRI findings of xanthoma in the orbitofrontal region. 1517 7