Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020440 (hypercapnia)
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Human Gene/Protein
ORX1 9.6
Phox2b 8.8
SLC9A2 8.6
HCAP 8.6
Fas-activated serine/threonine kinase 8.3
SLC9A3 7.9
Kir5.1 7.8
TAP-like 7.8
ZFHX4 7.8
Ret proto-oncogene 7.6
DMO 7.6
TASK-2 7.6
receptor for advanced glycosylation end products 7.5
CO2 7.4
ring finger protein 1 7.4
V5-6 7.4
neural adhesion molecule 7.3
ACZ 7.3
ALT2 7.2
SAP-2 7.1
Daw 7.1
CBF 7.1
nucleoredoxin 7.1
M6b 7.1
soluble adenylyl cyclase 6.9
TASK-1 6.9
NBC1 6.8
F1Fo-ATPase 6.8
T cell-specific adapter protein 6.8
Kir2.3 6.8
CL6 6.7
SNIP 6.7
ZFHX3 6.6
Tip110 6.6
ASIC4 6.6
PHOX2A 6.5
RING1A 6.3
ABG 6.3
C1 segment 6.2
orexin receptor-1 6.2
TASK-3 6.2
Down syndrome cell adhesion molecule 6.2
SIDS 6.2
ATBF1 6.2
vacuolar-type H(+)-ATPase 6.2
ASL 6.2
FOXF2 6.2
long chain acyl-CoA dehydrogenase 6.2
CAIV 6.1
NHE2 6.1
COPD 6.1
ATPase mRNA 6.1
CAII 6.0
glutamate dehydrogenase 1 6.0
KDM2A 5.9
CPAP 5.9
Kir4.1 5.9
RLF 5.8
sodium bicarbonate cotransporter 5.8
C3-C5 5.8
IKBKAP 5.8
NTS 5.8
KCNT1 5.7
SNM1 5.7
ASIC3 5.7
P2X2 5.7
early growth response 2 5.6
NEB 5.6
Kir1.1 5.6
TASK1 5.6
ASIC1 5.6
POD1 5.5
HO-2 5.5
TRIM24 5.5
RECA 5.5
P100 5.5
NHE3 5.5
DSH 5.4
SLC26A6 5.4
CBX 5.4
more...
Disease
Congenital central alveolar hypoventilation syndrome 12.0
Chronic pulmonary insufficiency of prematurity 12.0
Adenotonsillitis 12.0
Chronic respiratory acidosis 11.2
Pulmonary pneumatocele 11.0
Central alveolar hypoventilation syndrome 10.6
Acute respiratory acidosis 10.2
respiratory acidosis 10.0
Hemorrhagic pulmonary edema 10.0
Uremic acidosis 10.0
Intestinal dilatation 10.0
Congenital central hypoventilation syndrome 9.8
Idiopathic growth hormone deficiency 9.6
Obesity hypoventilation syndrome 9.6
Chronic hyperventilation 9.2
Vanishing lung 9.2
Migrainous infarction 9.0
Bulbar weakness 9.0
Chronic respiratory failure 9.0
Ondine's curse 8.9
Ondine's curse 8.9
TLPD 8.8
Breathholding 8.8
Central sleep apnea 8.7
Carotid body 8.5
Carotid body 8.5
Carotid body 8.5
Woakes' syndrome 8.4
Iatrogenesis 8.3
Neonatal respiratory distress 8.3
traumatic lung 8.2
pulmonary vascular disorder 8.2
Neonatal anoxia 8.2
Meconium ileus equivalent 8.1
status asthmaticus 7.9
tongue abscess 7.8
Pulmonary failure 7.8
Heparin-induced thrombocytopenia type II 7.7
vascular dilation 7.4
alkalosis 7.4
DSAP 7.3
Cor Pulmonale 7.3
cerebrovascular occlusion 7.2
Restrictive lung disease 7.2
Chronic lung disease 7.2
cor pulmonale 7.2
Respiratory morbidity 7.1
Overlap syndrome 7.0
sleep apnea 6.9
Hypothalamic dysfunction 6.9
Myxedema coma 6.9
HPNS 6.8
respiratory failure 6.8
obstructive sleep apnea 6.8
Meconium aspiration syndrome 6.8
multifocal atrial tachycardia 6.8
metabolic alkalosis 6.8
Cerebral hypoperfusion 6.7
Brown-Vialetto-Van Laere syndrome 6.7
LUNG 6.7
Pneumoperitoneum 6.7
carboxyhemoglobinemia 6.7
Necrotizing pneumonia 6.6
Diaphragm 6.5
autonomic disorder 6.5
secondary polycythemia 6.5
tension pneumothorax 6.5
Neonatal encephalopathy 6.4
anthracosilicosis 6.4
Water intoxication 6.4
hypochloremia 6.4
Tracheal stenosis 6.2
sudden infant death syndrome 6.2
ARF 6.2
Diabetic autonomic neuropathy 6.2
tonsillar hypertrophy 6.1
Acute asthma 6.1
Gerhardt 6.1
hyperventilation syndrome 6.1
nervous disorder 6.1
more...
Symptom
hypercapnia 12.0
Jaw stiffness 11.0
Biot's breathing 10.4
Increased work of breathing 10.4
hypocapnia 10.1
disintegration of the body 10.0
Chronic hypoventilation 9.6
Flaccidity 9.4
Dyspnea at rest 8.8
Apneusis 8.5
Gasping 8.4
Paroxysmal hypertension 8.3
Periodic breathing 8.1
hyperoxia 8.0
breath holding 7.9
Action myoclonus 7.8
Diaphragmatic weakness 7.7
Respiratory abnormalities 7.6
Hoover's sign 7.4
Trembling 7.3
Postoperative nausea 7.3
bradypnea 7.3
Lung hyperinflation 7.2
abnormal breathing 7.0
Organ failure 7.0
Acute dyspnea 7.0
Mouth breathing 6.9
Orthostasis 6.8
tachypnea 6.4
Induced hypothermia 6.3
labored breathing 6.2
sinus pressure 6.2
phosphatemia 6.2
muscle rigidity 6.1
CSR 6.0
snoring 5.9
orthopnea 5.4
Anoxia 5.4
Sedation 5.4
sighing 5.4
respiratory distress 5.3
stridor 5.1
cyanosis 5.0
dyspnea 5.0
bigeminal 5.0
hypothermia 4.8
hypersomnia 4.7
physical exhaustion 4.6
anesthesia 4.5
Regurgitation 4.5
twitching 4.4
sleepiness 4.3
asterixis 4.3
rales 4.2
aphonia 4.0
lightheadedness 4.0
Postoperative nausea and vomiting 3.9
Postoperative pain 3.9
hunger 3.8
bedwetting 3.8
presyncope 3.7
sneezing 3.7
eds 3.5
cough 3.5
Poor sleep 3.5
clonus 3.4
weakness 3.4
chest tightness 3.4
fatigue 3.4
collapse 3.4
analgesia 3.3
breakthrough pain 3.3
exertional dyspnea 3.2
tonic-clonic seizure 3.2
clubbing 3.2
hypotonia 3.2
muscle cramps 3.1
blackout 3.1
Respiratory symptoms 3.1
wheezing 3.1
more...
Drug
Triflocin 12.0
Dimexidum 10.0
Pentamorphone 9.6
Vectarion 8.4
Aramine 8.3
Aramine 8.2
Arfonad 8.0
LCBF 7.8
Arfonad 7.4
Innovar 7.2
Doxapram 6.9
Diamox 6.7
Dantrolene sodium 6.2
Pentothal 6.1
Prulifloxacin 5.9
Phosphoramidon 5.8
Methohexitone 5.8
Helium 5.7
Cibenzoline 5.6
Butorphanol 5.5
7-Nitroindazole 5.5
Carbenoxolone 5.4
Dormicum 5.4
IPD 5.3
Sodium acetate 5.3
Thiopentone 5.3
Morphine sulfate 5.1
Ammonium chloride 5.1
Lugol's solution 5.0
Fentanyl 5.0
Enoximone 4.9
Flurazepam 4.8
CFX 4.7
2-Methoxyestradiol 4.6
Domperidone 4.6
SF6 4.5
Ritanserin 4.5
Fenoldopam 4.4
Amiloride 4.4
Propofol 4.4
SBT 4.3
Amiloride 4.3
C3H6 4.3
Ipratropium bromide 4.3
Papaverine 4.1
Prozac 4.0
Theophylline 4.0
metformin hydrochloride 4.0
Bupivacaine 4.0
Magnesium sulfate 4.0
Sinemet 3.9
Triazolam 3.9
Indomethacin 3.8
Digitalis 3.7
DM1 3.7
Kainic acid 3.6
Sodium nitroprusside 3.6
CPR 3.6
Piracetam 3.5
EPI 3.5
Zonisamide 3.4
MgSO4 3.4
Clonidine 3.3
Bumetanide 3.3
Aminoguanidine 3.2
Timolol 3.2
Pregabalin 3.2
MAP 3.1
FeCl3 3.1
Viagra 3.1
Reserpine 3.0
Salbutamol 3.0
nitroglycerin 2.9
Iloprost 2.9
Atropine 2.9
Indocyanine green 2.8
Viagra 2.8
Phentolamine 2.8
CoCl2 2.7
CoCl2 2.7
more...
Enzyme
tauropine dehydrogenase 8.2
Tpa 7.6
carbonic anhydrase 5.3
endothelin-converting enzyme 4.7
CAO 4.5
NQO2 4.4
tryptophan hydroxylase 4.4
CCS 4.3
PPH 4.0
PHT 4.0
MsrB 4.0
SPT 3.9
MAP 3.9
CDH 3.8
dimethylarginine dimethylaminohydrolase 3.7
PRA 3.6
SPT 3.2
prostaglandin synthetase 3.1
NO synthase 3.1
AMP-activated kinase 3.1
adenosine kinase 3.1
meprin 2.9
ADH 2.8
15-hydroxyprostaglandin dehydrogenase 2.7
tyrosine hydroxylase 2.6
type III procollagen 2.5
heme oxygenase 2.5
NOS 2.5
chalcone synthase 2.4
FAST 2.4
PAT 2.2
adenosine deaminase 2.2
creatine kinase 2.2
adenosine deaminase 2.2
caspase-7 2.2
p100 2.2
renin 2.1
caspase-7 2.1
C3 convertase 2.1
glutaminase 2.1
phosphofructokinase 2.1
DOPA decarboxylase 1.9
CPR 1.9
guanylate cyclase 1.9
citrate synthase 1.8
lysyl oxidase 1.7
PKG 1.7
heparinase 1.7
CaMKII 1.6
ATPase 1.6
AMP-activated protein kinase 1.5
histidine decarboxylase 1.5
complex I 1.4
pyruvate carboxylase 1.4
CPT 1.4
hyaluronidase 1.4
Alternating 1.4
AMPK 1.3
choline acetyltransferase 1.3
CPT 1.3
MIP 1.3
glutamine synthetase 1.3
phosphoglucose isomerase 1.2
CPT 1.2
pyruvate dehydrogenase 1.2
pyruvate dehydrogenase 1.2
glycerol-3-phosphate dehydrogenase 1.2
glycerol-3-phosphate dehydrogenase 1.2
prolyl hydroxylase 1.1
arginase 1.1
phosphodiesterase 1.1
BAL 1.0
hyaluronidase 1.0
alpha-glucosidase 0.9
NADH dehydrogenase 0.9
cytochrome oxidase 0.9
soluble epoxide hydrolase 0.9
superoxide dismutase 0.8
ACE 0.8
alcohol dehydrogenase 0.8
more...
Compound
Evoxine 12.0
Tetracosahexaenoic acid 9.4
5-Iodotubercidin 8.4
TS-160 8.4
5-Iodotubercidin 8.4
5-Iodotubercidin 8.4
5-Iodotubercidin 8.3
Methazolamide 7.9
DMO 7.6
3,3-dimethyl-1-butanol 7.6
Prochlorperazine 7.4
Potassium bromide 7.1
Sodium cyanide 7.1
Acetazolamide 6.9
CO2 6.9
Protriptyline 6.8
Sufentanil 6.8
Phenamil 6.8
Medroxyprogesterone 6.6
N-phenylbenzamide 6.4
Tiapamil 6.4
Diethyl pyrocarbonate 6.4
Dantrolene sodium 6.4
Droperidol 6.3
N-methylbenzamide 6.2
Desflurane 6.1
Methionine sulfoximine 6.1
DDVP 6.1
dITP 6.0
D-Arginine 5.8
Phosphoramidon 5.8
Mepivacaine 5.8
Aminophylline 5.7
Halothane 5.7
Dormicum 5.7
Oleoylethanolamide 5.7
Dantrolene 5.6
Butorphanol 5.6
Muscimol 5.6
Naloxonazine 5.6
HCO 5.6
Sisomicin 5.6
Domperidone 5.5
CHNO 5.5
Cereb 5.4
IPD 5.4
Sodium lactate 5.4
EVE 5.3
Morphine sulfate 5.3
Sodium acetate 5.3
HSM 5.2
DPG 5.2
N2O 5.1
Sevoflurane 5.1
Chloramine-T 5.1
carbonic acid 5.1
carbonic acid 5.1
carbonic acid 5.1
carbonic acid 5.1
carbonic acid 5.1
carbonic acid 5.1
carbonic acid 5.1
carbonic acid 5.1
carbonic acid 5.1
carbonic acid 5.0
carbonic acid 5.0
carbonic acid 5.0
carbonic acid 5.0
carbonic acid 5.0
carbonic acid 5.0
carbonic acid 5.0
Tolazoline 5.0
Kynurenic acid 5.0
carbonic acid 5.0
carbonic acid 5.0
Naloxone 5.0
Taxifolin 4.9
Ephedrine 4.9
Salvinorin A 4.8
2-Deoxy-D-glucose 4.8
more...