Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020440 (hypercapnia)
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Human Gene/Protein
ORX1 9.6
Phox2b 8.8
HCAP 8.6
SLC9A2 8.6
Fas-activated serine/threonine kinase 8.3
SLC9A3 7.9
Kir5.1 7.8
ZFHX4 7.8
TAP-like 7.8
Ret proto-oncogene 7.6
DMO 7.6
TASK-2 7.6
receptor for advanced glycosylation end products 7.5
CO2 7.4
V5-6 7.4
ring finger protein 1 7.4
neural adhesion molecule 7.3
ACZ 7.3
ALT2 7.2
SAP-2 7.1
Daw 7.1
CBF 7.1
M6b 7.1
nucleoredoxin 7.1
soluble adenylyl cyclase 6.9
TASK-1 6.9
NBC1 6.8
T cell-specific adapter protein 6.8
F1Fo-ATPase 6.8
Kir2.3 6.8
SNIP 6.7
CL6 6.7
ZFHX3 6.6
Tip110 6.6
ASIC4 6.6
PHOX2A 6.5
RING1A 6.3
ABG 6.3
C1 segment 6.2
orexin receptor-1 6.2
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Disease
Congenital central alveolar hypoventilation syndrome 12.0
Adenotonsillitis 12.0
Chronic pulmonary insufficiency of prematurity 12.0
Chronic respiratory acidosis 11.2
Pulmonary pneumatocele 11.0
Central alveolar hypoventilation syndrome 10.6
Acute respiratory acidosis 10.2
respiratory acidosis 10.0
Uremic acidosis 10.0
Hemorrhagic pulmonary edema 10.0
Intestinal dilatation 10.0
Congenital central hypoventilation syndrome 9.8
Idiopathic growth hormone deficiency 9.6
Obesity hypoventilation syndrome 9.6
Chronic hyperventilation 9.2
Vanishing lung 9.2
Chronic respiratory failure 9.0
Bulbar weakness 9.0
Migrainous infarction 9.0
Ondine's curse 8.9
Ondine's curse 8.9
TLPD 8.8
Breathholding 8.8
Central sleep apnea 8.7
Carotid body 8.5
Carotid body 8.5
Carotid body 8.5
Woakes' syndrome 8.4
Iatrogenesis 8.3
Neonatal respiratory distress 8.3
traumatic lung 8.2
Neonatal anoxia 8.2
pulmonary vascular disorder 8.2
Meconium ileus equivalent 8.1
status asthmaticus 7.9
tongue abscess 7.8
Pulmonary failure 7.8
Heparin-induced thrombocytopenia type II 7.7
vascular dilation 7.4
alkalosis 7.4
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Symptom
hypercapnia 12.0
Jaw stiffness 11.0
Increased work of breathing 10.4
Biot's breathing 10.4
hypocapnia 10.1
disintegration of the body 10.0
Chronic hypoventilation 9.6
Flaccidity 9.4
Dyspnea at rest 8.8
Apneusis 8.5
Gasping 8.4
Paroxysmal hypertension 8.3
Periodic breathing 8.1
hyperoxia 8.0
breath holding 7.9
Action myoclonus 7.8
Diaphragmatic weakness 7.7
Respiratory abnormalities 7.6
Hoover's sign 7.4
Postoperative nausea 7.3
Trembling 7.3
bradypnea 7.3
Lung hyperinflation 7.2
abnormal breathing 7.0
Organ failure 7.0
Acute dyspnea 7.0
Mouth breathing 6.9
Orthostasis 6.8
tachypnea 6.4
Induced hypothermia 6.3
labored breathing 6.2
sinus pressure 6.2
phosphatemia 6.2
muscle rigidity 6.1
CSR 6.0
snoring 5.9
orthopnea 5.4
Anoxia 5.4
Sedation 5.4
sighing 5.4
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Drug
Triflocin 12.0
Dimexidum 10.0
Pentamorphone 9.6
Vectarion 8.4
Aramine 8.3
Aramine 8.2
Arfonad 8.0
LCBF 7.8
Arfonad 7.4
Innovar 7.2
Doxapram 6.9
Diamox 6.7
Dantrolene sodium 6.2
Pentothal 6.1
Prulifloxacin 5.9
Phosphoramidon 5.8
Methohexitone 5.8
Helium 5.7
Cibenzoline 5.6
Butorphanol 5.5
7-Nitroindazole 5.5
Carbenoxolone 5.4
Dormicum 5.4
IPD 5.3
Sodium acetate 5.3
Thiopentone 5.3
Morphine sulfate 5.1
Ammonium chloride 5.1
Lugol's solution 5.0
Fentanyl 5.0
Enoximone 4.9
Flurazepam 4.8
CFX 4.7
2-Methoxyestradiol 4.6
Domperidone 4.6
SF6 4.5
Ritanserin 4.5
Fenoldopam 4.4
Amiloride 4.4
Propofol 4.4
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Enzyme
tauropine dehydrogenase 8.2
Tpa 7.6
carbonic anhydrase 5.3
endothelin-converting enzyme 4.7
CAO 4.5
NQO2 4.4
tryptophan hydroxylase 4.4
CCS 4.3
PPH 4.0
PHT 4.0
MsrB 4.0
SPT 3.9
MAP 3.9
CDH 3.8
dimethylarginine dimethylaminohydrolase 3.7
PRA 3.6
SPT 3.2
prostaglandin synthetase 3.1
NO synthase 3.1
AMP-activated kinase 3.1
adenosine kinase 3.1
meprin 2.9
ADH 2.8
15-hydroxyprostaglandin dehydrogenase 2.7
tyrosine hydroxylase 2.6
type III procollagen 2.5
heme oxygenase 2.5
NOS 2.5
chalcone synthase 2.4
FAST 2.4
PAT 2.2
adenosine deaminase 2.2
creatine kinase 2.2
adenosine deaminase 2.2
caspase-7 2.2
p100 2.2
renin 2.1
caspase-7 2.1
C3 convertase 2.1
glutaminase 2.1
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Compound
Evoxine 12.0
Tetracosahexaenoic acid 9.4
5-Iodotubercidin 8.4
5-Iodotubercidin 8.4
TS-160 8.4
5-Iodotubercidin 8.4
5-Iodotubercidin 8.3
Methazolamide 7.9
DMO 7.6
3,3-dimethyl-1-butanol 7.6
Prochlorperazine 7.4
Potassium bromide 7.1
Sodium cyanide 7.1
Acetazolamide 6.9
CO2 6.9
Protriptyline 6.8
Sufentanil 6.8
Phenamil 6.8
Medroxyprogesterone 6.6
N-phenylbenzamide 6.4
Tiapamil 6.4
Diethyl pyrocarbonate 6.4
Dantrolene sodium 6.4
Droperidol 6.3
N-methylbenzamide 6.2
Desflurane 6.1
Methionine sulfoximine 6.1
DDVP 6.1
dITP 6.0
D-Arginine 5.8
Phosphoramidon 5.8
Mepivacaine 5.8
Aminophylline 5.7
Halothane 5.7
Dormicum 5.7
Oleoylethanolamide 5.7
Dantrolene 5.6
Butorphanol 5.6
Muscimol 5.6
Naloxonazine 5.6
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