Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020440 (hypercapnia)
 7,939 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The burrow-dwelling woodchuck (Marmota monax) (mean body wt. = 4.45 +/- 1 kg) was compared to a similar-sized (5.87 +/- 1.5 kg) but arboreal rodent, the porcupine (Erithrizon dorsatum), in terms of its ventilatory and heart rate responses to hypoxia and hypercapnia, and its blood characteristics. VT, f, T1 and TE were measured by whole-body plethysmography in four awake individuals of each species. The woodchuck has a longer TE/TTOT (0.76 +/- 0.03) than the porcupine (0.61 +/- 0.03). The woodchuck had a higher threshold and significantly smaller slope to its CO2 ventilatory response compared to the porcupine, but showed no difference in its hypoxic ventilatory response. The woodchuck P50 of 27.8 was hardly different from the porcupine value of 30.7, but the Bohr factor, -0.72, was greater than the porcupine's, -0.413. The woodchuck breathing air has PaCO2 = 48 (+/- 2) torr, PaO2 = 72 (+/- 6), pHa = 7.357 (+/- 0.01); the porcupine blood gases are PaCO2 = 34.6 (+/- 2.8), PaO2 = 94.9 (+/- 5), pHa = 7.419 (+/- 0.03), suggesting a difference in PaCO2/pH set points. The woodchuck exhibited no reduction in heart rate with hypoxia, nor did it have the low normoxic heart rate observed in other burrowing mammals.
 ...
PMID:Cardiorespiratory responses of the woodchuck and porcupine to CO2 and hypoxia. 251 13