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Query: UMLS:C0020440 (
hypercapnia
)
7,939
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We studied the expression of chaperone
GRP
-78 and transcription factor NF-kB during the development of ischemic tolerance of the brain after combined and isolated exposure to hypoxia and
hypercapnia
. Combined exposure to hypoxia and
hypercapnia
maximally increased the expression of chaperone
GRP
-78 and transcription factor NF-kB, while the formation of ischemia-induced tolerance under conditions of hypercapnic hypoxia can be associated with activation of adaptive stress mechanisms in the endoplasmic reticulum. Under these conditions,
hypercapnia
in combination with hypoxia is a priority factor for activation of
GRP
-78 and transcription factor NF-kB.
...
PMID:Stress of the Endoplasmic Reticulum of Neurons in Stroke Can Be Maximally Limited by Combined Exposure to Hypercapnia and Hypoxia. 2759 67
