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Query: UMLS:C0020440 (
hypercapnia
)
7,939
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Chronic obstructive pulmonary disease (COPD) is a respiratory illness characterized by airflow limitation and chronic respiratory symptoms with a global prevalence estimated to be more than 10% in 2010 and still on the rise. Furthermore, hypercapnic subject COPD leads to an increased risk of mortality, morbidity, and poor QoL (quality of life) than normocapnic subjects. Series of studies showed the usefulness of the forced oscillation technique (FOT) to measure small airway closure. Traditional findings suggested that
hypercapnia
may not be the main treating targets, but recent findings suggested that blood stream CO
2
may lead to a worse outcome. This study aimed to seek the relationship between CO
2
and small airway closure by using FOT. Subjects with COPD (
n
= 124;
hypercapnia
22 and normocapnia 102) were analyzed for all pulmonary function values, FOT values, and arterial blood gas analysis. Student's
t
-test, Spearman rank correlation, and multi linear regression analysis were used to analyze the data. COPD subjects with
hypercapnia
showed a significant increase in R5, R20, Fres, and
ALX
values, and a greater decrease in X5 value than normocapnic patients. Also, multiple linear regression analysis showed R5 was associated with
hypercapnia
.
Hypercapnia
may account for airway closure among subjects with COPD and this result suggests treating
hypercapnia
may lead to better outcomes for such a subject group.
...
PMID:Correlation of Arterial CO
2
and Respiratory Impedance Values among Subjects with COPD. 3287 65
