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Query: UMLS:C0020440 (hypercapnia)
 7,939 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Perinatal asphyxia is a significant contributor to neonatal brain injury. However, there is significant variability in neurological outcome in neonates after global hypoxia-ischemia. The aims of this study were to identify which physiological response/s during global hypoxia-ischemia influence the severity of brain injury and to assess their relative importance. Hypoxia/hypercapnia was induced in 20 anaesthetized piglets by reducing the inspired oxygen fraction to 10% and the ventilation rate from 30 to 10 breaths per minute for 45 min. Neurological outcome was assessed using functional markers including cerebral function amplitude (via electroencephalography) and cerebral impedance, and the structural marker microtubule associated protein-2 by immunohistochemistry at 6 h post hypoxia. Significant variability in neurological outcome was observed following the constant hypoxia/hypercapnia insult. There was a high degree of variability in cardiovascular function (mean arterial blood pressure and heart rate) and serum cortisol concentrations in response to hypoxia. More effective maintenance of cardiovascular function and higher serum cortisol concentrations were associated with a better outcome. These two variables were strongly associated with neurological outcome, and together explained 68% of the variation in the severity of neurological outcome. The variability in the cardiovascular and cortisol responses to hypoxia may be a more important determinant of neurological outcome then previously recognized.
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PMID:Associations between serum cortisol, cardiovascular function and neurological outcome following acute global hypoxia in the newborn piglet. 1895 Dec 50

The function of the cardiovascular system during hypoxia is an important determinant of neurologic outcome. Oscillations in blood pressure, particularly type-3 waves with a duration of 10 to 160 s, have been shown to occur in the presence of hypoxia in the neonatal rat. The aim of this study was to determine the characteristics and occurrence of type-3 waves in the neonatal piglet and any relationship to neurologic damage after acute global hypoxia. Hypoxia/hypercarbia was induced in 32 anesthetized piglets by reducing the fraction of inspired oxygen to 0.1 and the ventilation rate from 30 to 10 breaths per minute for 45 min. The degree of neurologic damage was assessed using both physiologic (EEG amplitude and cerebral impedance at 6 h posthypoxia) and structural (microtubule associated protein-2 immunohistochemistry) markers. Type-3 waves in cardiovascular function occurred in 56% of animals. An oscillating pattern was significantly associated with less neurologic damage (p = 0.01) and a lower duration of hypotension during hypoxia (p = 0.02), and occurred more frequently in females (p = 0.024).
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PMID:Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in females. 1919 May 42