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Query: UMLS:C0020440 (hypercapnia)
 7,939 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although the physiological effects of positive pressure ventilation are numerous, sometimes undesirable and have varying degrees of significance, positive pressure ventilation still plays a major role in the resuscitation and treatment of critically ill patients. Advances in the various methods of delivering positive pressure, especially when incorporating spontaneous breathing, have reduced the severity of complications. Despite serious complications, mechanical ventilation has advantages. When it is instituted for ventilatory and hypoxaemic respiratory failure, the benefits can be viewed in the context of the work of breathing. Spontaneous breathing normally requires 5% of total oxygen delivery to meet its demands. In lung disease, the ratio of oxygen consumption by the respiratory muscles to whole body oxygen consumption can increase to 25-30% (Henning 1986, Pinksy 1990). Mechanical ventilation reduces the energy demand of respiratory muscles and increases the oxygen delivery to other vital organs. When mechanical ventilation improves hypoxaemia and/or hypercarbia, or significantly decreases the work of breathing, it may also normalize associated changes in heart rate (Perel & Pizov 1991 p53). When cardiac output is increased in response to the increased work of breathing and associated stress, the institution of mechanical ventilation may beneficially lower the cardiac output simply due to the decrease in oxygen demand; thus the physiological reduction in cardiac output may not necessarily be regarded as a complication. The effects of raised intrathoracic pressure during mechanical ventilation may be beneficial when used to prevent or reduce pulmonary oedema, though problematic in some other situations. Mechanical ventilation is a life-saving treatment which has many associated complications; nurses have to accept the unavoidable hazards and adapt their nursing care to minimize their effects.
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PMID:Physiological changes occurring with positive pressure ventilation: Part Two. 956 54

This study examined the interaction between hyperthyroidism and opioid receptor function on control of ventilation and metabolism in male Harlan hamsters 4 and 8 weeks after implanting thyroxine (T(4)) or placebo pellets. Metabolism, but not body temperature, increased in T(4)-treated hamsters relative to placebo-treated animals. After 4 weeks, body weights were greater in the T(4)-treated hamsters, but comparable to controls after 8 weeks. At that time, body length was greater in T(4)-treated hamsters than in controls. Thyroxine did not affect ventilation in air or in response to CO(2). Naloxone, an opioid receptor antagonist, decreased metabolism in T(4)-treated, but not in placebo-treated hamsters without affecting ventilation in air in either group. In the placebo group naloxone augmented the ventilatory response to hypercapnia by increasing frequency. These results negate our hypotheses that: (1) hyperthyroid hamsters exhibit greater ventilation in air and in response to hypercapnia than controls; and (2) that naloxone augments these effects.
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PMID:Effects of thyroxine and naloxone administration on metabolism and ventilation in hamsters. 1099 88