Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020440 (
hypercapnia
)
7,939
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Inhabiting deep and sealed subterranean burrows, mole rats exhibit a remarkable suite of specializations, including eusociality (living in colonies with single breeding queens), extraordinary longevity, cancer immunity and poikilothermy, and extreme tolerance of hypoxia and
hypercapnia
. With little information available on adjustments in haemoglobin (Hb) function that may mitigate the impact of exogenous and endogenous constraints on the uptake and internal transport of O
2
, we measured haematological characteristics, as well as Hb-O
2
binding affinity and sensitivity to pH (Bohr effect), CO
2
, temperature and 2,3-diphosphoglycerate (
DPG
, the major allosteric modulator of Hb-O
2
affinity in red blood cells) in four social and two solitary species of African mole rats (family Bathyergidae) originating from different biomes and soil types across Central and Southern Africa. We found no consistent patterns in haematocrit (Hct) and blood and red cell
DPG
and Hb concentrations or in intrinsic Hb-O
2
affinity and its sensitivity to pH and
DPG
that correlate with burrowing, sociality and soil type. However, the results reveal low specific (pH independent) effects of CO
2
on Hb-O
2
affinity compared with humans that predictably safeguard pulmonary loading under hypoxic and hypercapnic burrow conditions. The O
2
binding characteristics are discussed in relation to available information on the primary structure of Hbs from adult and developmental stages of mammals subjected to hypoxia and
hypercapnia
and the molecular mechanisms underlying functional variation in rodent Hbs.
...
PMID:O
2
binding and CO
2
sensitivity in haemoglobins of subterranean African mole rats. 2885 19
<< Previous
1
2
