Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020440 (hypercapnia)
 7,939 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 2,980-gram female infant was born to a 25-year-old mother at the gestational age of 34 weeks with the chief problems of asphyxia and respiratory distress. Prenatal sonogram at 34th week of gestation showed significant pleural effusion, mediastinal shift, polyhydramnios and large for date. Soon after birth, she was put on intubation and ventilator therapy. Physical examination revealed poor chest wall excursion. Breathing sound was markedly decreased over the right lung field. Abdomen was soft and slightly distended with the liver palpable 0.5 cm below the right costal margin and 2 cm below the xyphoid process. Arterial blood gas with patient breathing 100% oxygen revealed severe acidosis and carbon dioxide retention. The first chest film showed right pleural effusion. Chest tap was performed, and 90 cc serosanguineous fluid was aspirated. The white cells of the effusion were 1,971 with lymphocyte predominant. No microorganism or malignant cell was found. Severe respiratory distress and cyanosis persisted inspite of these managements. Follow up chest film at the age of 11 hours revealed the right chest was occupied by intestinal loops. A thoracotomy was performed with the impression of right diaphragmatic hernia. The operation findings included a very redundant membranous portion of diaphragm formed a large sac containing the liver and some bowel loops, the lower lobe of the right lung collapsed and was located high in the posterior chest cavity. Diaphragmatic plication and excision were done with transient improvement of the skin color. The baby's condition deteriorated and expired at the age of 25 hours despite of postoperative vasodilator and ventilator therapies.(ABSTRACT TRUNCATED AT 250 WORDS)
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:[Congenital right diaphragmatic eventration manifested with pleural effusion. Report of one case]. 263 24

Conventional ventilators have their limitations in management of certain conditions such as protracted hypercarbia in bronchopulmonary dysplasia (BPD). Although high-frequency ventilators (HFV) may be less effective in patients with lung diseases complicated by high airway resistance, such as BPD, high-frequency oscillatory ventilators (HFOV) can still provide an alternative treatment of choice due to its property of active exhalation, in addition to its tidal volume being less than dead space and its minute ventilation being more dependent on tidal volume. This report describes 3 episodes of successful relief of protracted hypercarbia in a young infant with BPD using HFOV after failure of conventional ventilatory therapy.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:Relief of protracted hypercarbia by high-frequency oscillatory ventilator in a young infant with bronchopulmonary dysplasia. 906 92