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Query: UMLS:C0020440 (
hypercapnia
)
7,939
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In order to study the influence of
hypercapnia
on the content of glutamate and glutamine in the developing brain, pregnant rats and their offspring were kept in CO2 rich (6-10%) atmosphere and the litters were killed at different ages between 4 and 28 days. In the hypercapnic rats the content of both amino acids in the brain increases with age with almost the same time course as in normocapnic rats. At any age the glutamate content is lower in the hypercapnic animals than in control rats, whereas the glutamine content, beyond the first 8 days of life is increased. Both effects are rapidly reversible on return to air breathing. Although the glutamate-glutamine system is in full development, the influence of
hypercapnia
can be compared to that observed in adult rats.
Hypercapnia
did not change the
glutaminase
and the glutamine synthetase activity of the brain.
...
PMID:Glutamate and glutamine in the brain of the neonatal rat during hypercapnia. 7 Oct 88
Experiments on rats have shown an important role of
hypercapnia
in the development of condition of artificial hibernation in combination with influence of hypothermia, hypoxia and
hypercapnia
. It is proved that the joint action of hypothermia, hypoxia and
hypercapnia
has induced development of respiratory acidosis and hibernation in animals, while removal of the
hypercapnia
effect has induced development of acute metabolic acidosis and death of animals. It has been found that animals in the state of artificial hibernation have considerable changes in concentrations of main electrolytes (Na+, K+, Ca+, Mg2+, phosphates, Cl-) and metabolites (NH3, glutamine, urea) in blood as well as in activity of enzymes (glutamaldehydrogenase,
glutaminase
, arginase) in tissues of the liver and kidneys.
...
PMID:[Acid-base equilibrium and nitrogen metabolism in rats in a state of artificial hibernation]. 855 76
