Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020440 (hypercapnia)
 7,939 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypercapnic and hypoxic ventilatory sensitivities were compared in twenty-one judoists and 24 control subjects with similar degrees of moderate obesity. Data from ten non-obese control subjects were also included as a reference. Mean body weight (BW) and % of ideal body weight in the judoists and the obese and non-obese controls were 100 +/- 14.8, 94.4 +/- 5.3 and 63.4 +/- 6.1 (mean +/- SD) kg, and 142.3 +/- 16.7, 142.2 +/- 12.9 and 98.4 +/- 10.7%, respectively. Mean body fat in the judoists was 16.2 +/- 13.9%, being 25.3 +/- 7.7% in the obese control group, the difference being significant (p less than 0.01). Hypercapnic sensitivities in terms of the CO2 ventilatory response slope (S) and its normalized value for 70 kg BW (SN) of the obese controls were higher than the judoists. These findings were also verified by the CO2-occlusion pressure responses. S and SN in the obese controls were significantly correlated with BW and % body fat. However, no positive correlation was found between BW and S or SN in the judoists as well as between lean body mass and S or SN in the obese control. Hypoxic sensitivity in terms of the PETO2-ventilation hyperbola slope (A) and its normalized value (AN) in the obese control was significantly higher than the non-obese control, but the difference from the judoists was not significant. A and AN were found to increase with increasing % body fat in both judoists and obese controls.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Differences in ventilatory responses to hypoxia and hypercapnia between normal and judo athletes with moderate obesity. 356 19

In obese subjects with chronic bronchitis hypercapnia by limitation of tidal volume regresses if a slow ventilatory frequency is imposed by lengthening of expiration time. But hypoxemia due to shunt effect can either be corrected by global improvement of alveolar ventilation VA or persist and become worse by low pulmonary volume ventilation which lowers VA/Q. The effect of bradypnoea on 11 elderly patients with moderate obesity has been evaluated by simultaneous measurements of blood gases, ventilatory output coefficients, gas flow rate and steady state transfer for CO. Although hypo-VA disappeared in bradypnoea, hypoxemia persisted in 5 cases, the increase of P(Aa)O2 was accentuated in 7 cases, VCO always remained in deficit compared with VCO2 (in healthy subjects at rest, VCO and VCO2 are interrelated by a proportionally constant whatever the respiratory regimen: VCO/VCO2 = specific VCO, or VCO Sp). The VCO/VA variation correlated negatively with the P(Aa)O2 variation. This study: 1) confirms the link between PaCO2 and VT and the persistence of shunt effect bradypnoea compatible with the deficit of VCO versus VCO2; 2) distinguishes the efficiency of bradypnoea in ventilation and in alveolo-capillary exchange; 3) compares the variations of VCO Sp with those of PaO2 in relation to VT; 4) defines the characteristics of respiratory insufficiency in the obese and bronchitic subjects examined, and 5) specifies the value of VCO Sp measurement in testing the controlled ventilation technique used.
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PMID:[Gas exchange during spontaneous and controlled ventilation in obese subjects with chronic bronchitis. Value of normalized CO intake]. 804 79