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Target Concepts:
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Query: UMLS:C0020440 (
hypercapnia
)
7,939
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We describe polygraphic respiratory alterations during sleep in a child with
neurofibromatosis
. The patient, a four-year-old boy, had a medical history of
neurofibromatosis
and recurrent acute respiratory failure responsive to mechanical ventilation. All-night polysomnography showed severe nocturnal hypoventilation with marked
hypercapnia
(TcPaCO2 70 mmHg) and hypoxemia (SaO2 less than 40%). Nocturnal hypoxemia and
hypercapnia
and depressed response to the hyperoxic hypercapnic test confirmed the diagnosis of central hypoventilation syndrome. Cerebral magnetic resonance imaging disclosed lucent areas in the globus pallidus, mesencephalus and left upper pons. Therapy with nocturnal nasal positive bilevel ventilation reversed nocturnal hypoxemia and
hypercapnia
. This study suggests that patients with
neurofibromatosis
should be investigated for concomitant severe hypoventilation, particularly when clinical symptoms suggest brain stem lesions.
...
PMID:Neurofibromatosis associated with central alveolar hypoventilation syndrome during sleep. 794 20
