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Query: UMLS:C0020440 (hypercapnia)
 7,939 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ventilation and drainage are the two essential intrinsic functions of the sinus. Both of them are dependent upon the permeability of the ostium, whose caliber is extremely variable with respect to anatomical factors, and dynamic factors associated with the vasomotricity of the mucous membrane. In many subjects the ostial permeability is precarious, thus explaining the frequency of inflammatory sinus reactions. These are due, as the level of the middle ear, either to a transostial inoculation of pathogenic germs creating a microbial sinusitis, or to an ostial obstruction responsible for a hypoxia, a hypercapnia, and a local depression creating a a vacuo sinusitis. The second situation leads to conditions that are favorable for the development of the first and vice versa.
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PMID:[Physiology of the sinuses. Physiopathology of sinusitis]. 665 Jan 46

Asthma is a common and debilitating problem in children. Its many costs to society include morbidity, hospitalization and treatment expenses, and a rising mortality rate. This paper examines recent trends in therapy for status asthmaticus. Oxygen, inhaled beta-adrenergic agonists, and corticosteroids remain the cornerstones of therapy for the child with a severe exacerbation of asthma. Ipratropium bromide provides additional bronchodilatation in the patient who does not respond to standard therapy. Theophylline may have a role in chronic outpatient management of asthma, but the data supporting the addition of this medication in acute therapy for status asthmaticus are inconclusive. Antibiotics are only indicated in children with asthma complicated by infection, such as sinusitis or pneumonia. Magnesium sulfate and heliox may have a role in helping the asthmatic child who is critically ill and for whom other interventions have failed. Mechanical ventilation has many complications. The concept of permissive hypercapnia may be important in limiting barotrauma. Prevention of exacerbations of asthma include limiting environmental exposure to allergens and tobacco, using corticosteroids, and reinforcing compliance with therapy.
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PMID:Update on the management of status asthmaticus. 881 99