Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020440 (hypercapnia)
 7,939 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty-nine patients who had traumatic aortic rupture in the area of the isthmus and were treated less than one week after injury were studied. Most patients (N = 47) underwent repair using pump-oxygenator partial bypass; 7 had simple cross-clamping. Paraplegia developed in 4 during operation. One patient died of a head injury after receiving heparin for bypass. The experience with these patients and a critical review of the literature indicate that the use of extracorporeal circulation and avoidance of hypoxia and hypercapnia may decrease the probability of paraplegia. When laparotomy preceded thoracotomy, there were no clearly deleterious effects of heparinization.
 ...
PMID:Traumatic rupture of the aorta: emergency operation. 400 93

To evaluate ventilatory and respiratory muscle responses to hypercapnia in patients with paraplegia with paralysis of abdominal muscles, we studied seven patients with complete transection of the midthoracic cord (Th6-Th7) and six normal subjects. Minute ventilation (V E) and mean inspiratory flow responses to hypercapnia were similar in normal subjects and patients with paraplegia, but in the latter, at any given level of end-tidal CO(2) partial pressure (PET(CO(2))), tidal volume (VT) was reduced and frequency was increased. In normal subjects during hypercapnia, end-expiratory transpulmonary pressure (PL) and abdominal volume at end expiration decreased markedly, whereas end-expiratory volume of the rib cage (Vrc,E) remained constant, suggesting progressive recruitment of abdominal muscles. In patients with paraplegia compared to normal subjects the decrease in end-expiratory PL was reduced, and it was associated with a decrease in Vrc,E, suggesting recruitment of rib cage expiratory muscles. For a PET(CO(2)) of 70 mm Hg the estimated expiratory muscle contribution to VT was 10.3 and 28.4% (p < 0.02) in patients with paraplegia and normal subjects, respectively. We conclude that the V E-CO(2) relationship is preserved in patients with paraplegia with the development of a rapid and shallow pattern of breathing. This suggests that expiratory muscle paralysis elicits adaptation of the ventilatory control system similar to that observed in patients with generalized respiratory muscle weakness.
 ...
PMID:Ventilatory and respiratory muscle responses to hypercapnia in patients with paraplegia. 1090 42