Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020438 (hypercalciuria)
 2,502 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients with recurrent stone disease and hypercalciuria were cleared up according to Nordin's schedule. In cases of absorptive hypercalciuria, an ion exchanger operating in the intestine, sodium cellulose phosphate (SCP), is applied under strict control of oxalate, calcium and magnesium excretion as well as ionized calcium in serum. Under treatment with SCP (27 patients), we found a reduction in the renal excretion of calcium and magnesium, and, as a side effect, a significant augmentation of the renal oxalate excretion. In cases of resorptive or resorptive/absorptive hypercalciuria, except in patients with primary HPT, 23 patients were mediated by thiazides (Esidrix). This drug effects a marked decrease of urinary calcium based on a higher rate of reabsorption of calcium in the distal tubule. No severe side effects especially primary HPT were observed.
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PMID:Resorptive and absorptive hypercalciuria. Therapy with sodium cellulose phosphate or thiazides. 42 8

Presentation of the analytical results from the patients seen for lithiasic disease (LD) over a two-year period at the Hospital Reina Sofia, Tudela. This Hospital covers a homogeneous Health Area including 22 villages and a population of 76,000 people. The clinical cases of 785 patient diagnosed with LD between May 1988 and 1990 May are analyzed. Microhaematuria in fresh urine is detected in 64.20% patients and crystalluria in 33.37%. Significant bacteriuria is present in 5.73% of total patients with prevalence of E. coli in 42.4%. Only 2 cases of hyperparatiroidism were diagnosed during the study period but later another two cases of HPT were detected in bone injuries studied due to rheumatic disease. No normocalcemic HPT cases were diagnosed among suspected cases. The metabolic studies were of little use in our experience, maybe because of non-availability of basic analytical determinations such as citraturia. Nevertheless, higher values of urinary volume, calciuria and uricemia and lower values of magnesemia and magnesiuria were found in lithiasic patients that in control ones. Neither oxaluria or the remaining analytical parameters provide differential data. Hypercalciuria higher than 300 mg in seen in 28.6% of studied patients and in 12.5% of the control group.
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PMID:[Epidemics of urinary calculi in la Ribera de Navarra (II). Analytic studies]. 866 30