Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020438 (
hypercalciuria
)
2,502
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aldose reductase (
AKR1B1
) is the first enzyme in the polyol pathway through which glucose is converted to sorbitol, and has been implicated in the etiology of diabetic complications. However, its physiological role is still not well understood. In the kidney,
AKR1B1
is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. We report here that the mice lacking
AKR1B1
showed
hypercalciuria
, hypercalcemia, hypermagnesemia, and reduced ability to concentrate urine, suggesting a new physiological role of
AKR1B1
in divalent cation homeostasis.
...
PMID:Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis. 1103 18
