Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020438 (
hypercalciuria
)
2,502
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
ATP2B1
gene is associated with hypertension. We previously reported that systemic heterozygous
ATP2B1
-null (
ATP2B1
+/-
) mice exhibited hypertension due to impaired endothelial nitric oxide synthase (eNOS) activity and decreased nitric oxide (NO) production. The
ATP2B1
gene encodes plasma membrane calcium ATPase 1 (PMCA1), which has been thought to regulate only intracellular Ca
2+
concentration. However, recently, it has been suggested that
ATP2B1
works not only at cellular levels, but also throughout the entire body, including in the calcium metabolism, using small intestine-specific
ATP2B1
knockout mice. To clarify the roles of
ATP2B1
in the entire body and the effects of
ATP2B1
on blood pressure, we examined the alterations of calcium related factors in
ATP2B1
+/-
mice.
ATP2B1
+/-
mice exhibited hypocalcemia. The expression of
ATP2B1
in the kidney and small intestine decreased, and
hypercalciuria
was confirmed in
ATP2B1
+/-
mice. The intact-PTH levels were lower, and bone mineral density was increased in these mice. These results suggest that hypocalcemia is mainly a result of inhibited bone resorption without compensation by PTH secretion in the case of
ATP2B1
knockout. Moreover, NO production may be affected by reduced PTH secretion, which may cause the increase in vascular contractility in these mice. The
ATP2B1
gene is important for not only intra-cellular calcium regulation but also for calcium homeostasis and blood pressure control.
...
PMID:Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice. 2995 Jun 83
