Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020438 (hypercalciuria)
 2,502 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective study of 68 children with increased medullary echogenicity on renal ultrasound (US) examination showed nephrocalcinosis to be present in 42 patients. The cause was believed to be iatrogenic in 30 and noniatrogenic in 12. Furosemide therapy was responsible for 11 of the cases of iatrogenic nephrocalcinosis and vitamin D therapy for the remaining iatrogenic cases. Noniatrogenic nephrocalcinosis was seen with hypercalcemia, hypercalciuria, renal tubular acidosis and dystrophic calcification following renal tubular necrosis. In 26 patients, medullary deposits of urates or proteins, medullary fibrosis, or vascular congestion (due to a variety of diseases) appeared to account for the finding. These possibilities should be added to the differential diagnosis of hyperechoic renal pyramids when nephrocalcinosis is unlikely.
 ...
PMID:Echogenic renal pyramids in children. 184 53

Beyond polyuria following psychogenic polydipsia, in a more narrow sense, this condition may be classified into impaired water re-absorption (i) due to tubular injury or (ii) relative or absolute loss of function of antidiuretic hormone (ADH). Tubular injury may be caused by different toxins affecting the ascending Henle loop as hypercalciuria, drugs and antibiotics as tubular necrosis. ADH deficiency, either absolute or relative, occurs with central or peripheral diabetes insipidus, which is based on synthesis failure or loss of peripheral efficacy of ADH due to receptor malfunction. Diagnosis of polyuria rests upon a thirst challenge in conjunction with laboratory studies of osmolality in serum and urine, which discloses the non-function of the hypothalamic-renal axis. Administration of ADH may differentiate between central and peripheral diabetes insipidus.
 ...
PMID:[Polyuria]. 1704 78