Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020437 (hypercalcemia)
10,293 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
parathyroid hormone 2143
PTH 818
parathyroid hormone-related protein 679
Sep 660
calcitonin 575
alkaline phosphatase 381
parathormone 306
She 266
chronic renal failure 243
calcium-sensing receptor 188
Parathyroid hormone 156
vitamin D receptor 148
Mol 147
albumin 131
AMP 112
osteocalcin 96
insulin 89
Calcitonin 85
cytokine 77
RANKL 71
MRI 70
CYP24A1 69
CaSR 68
non-Hodgkin's lymphoma 63
vasopressin 62
gastrin 61
HPT 58
FHH 57
adenylate cyclase 54
lymphoid 52
renin 52
serum albumin 51
GFR 51
IL-6 50
collagen 50
osteoprotegerin 49
cage 49
IgA 47
Pol 47
tumor necrosis factor 47
gut 46
interleukin-6 44
prolactin 43
calcium sensing receptor 42
lactate dehydrogenase 41
osteosarcoma 40
Gen 39
CD4 38
somatostatin 38
growth hormone 36
thyroid hormone 35
PTH/PTHrP 35
thymus 34
RANK 34
endoplasmic reticulum 33
IL-1 33
parafibromin 33
Walker 32
FGF23 31
reserved 30
ACTH 30
MEN1 30
interferon 29
G protein-coupled receptor 29
hemoglobin 29
glycoprotein 27
OCT 27
type I collagen 27
LDH 27
CD8 26
polypeptide 26
VDR 25
glucagon 25
tartrate-resistant acid phosphatase 25
MDP 25
collecting duct 24
amylase 24
p21 24
CDC73 23
serum protein 23
more...
Disease
hypercalcemia 10293
cancer 2022
hyperparathyroidism 1719
primary hyperparathyroidism 1638
tumor 1522
multiple myeloma 781
adenoma 777
carcinoma 652
osteoporosis 569
renal failure 514
metastases 511
bone disease 493
hypercalciuria 465
bone metastases 445
hyperphosphatemia 411
sarcoidosis 388
anemia 352
lymphoma 345
breast cancer 342
chronic renal failure 290
leukemia 279
nephrocalcinosis 259
renal disease 257
hypoparathyroidism 250
hypertension 238
renal insufficiency 219
hypercalcemia of malignancy 195
lymphadenopathy 186
multiple endocrine neoplasia 185
nephrolithiasis 174
PDB 165
vitamin D deficiency 161
diabetes 158
Parathyroid carcinoma 158
squamous cell carcinoma 151
acute renal failure 147
pancreatitis 146
Parathyroid 145
osteomalacia 133
adult T-cell leukemia/lymphoma 133
spinal cord compression 133
adenocarcinoma 123
dehydration 122
acute pancreatitis 121
hyperthyroidism 110
paraneoplastic syndrome 109
prostate cancer 109
rickets 109
tuberculosis 106
renal impairment 105
parathyroid hyperplasia 99
renal osteodystrophy 98
lung cancer 98
proteinuria 94
tumor growth 92
Williams syndrome 91
renal cell carcinoma 90
hypoglycemia 88
osteitis 87
depression 80
hypervitaminosis 80
thrombocytopenia 80
pathological fracture 79
cardiovascular disease 72
calcinosis 71
uremia 70
non-Hodgkin's lymphoma 69
urolithiasis 68
Hodgkin's disease 67
confusion 66
hypothyroidism 66
acute lymphoblastic leukemia 63
MEN1 62
amyloidosis 60
primary tumor 60
psoriasis 60
Secondary hyperparathyroidism 58
Burnett 58
B-cell lymphoma 57
coma 56
more...
Symptom
pain 370
bone pain 326
vomiting 187
weakness 155
polyuria 147
nausea 144
anorexia 143
fatigue 137
lethargy 90
polydipsia 90
diarrhea 87
abdominal pain 86
constipation 84
cachexia 64
seizures 61
hepatosplenomegaly 56
headache 53
dyspnea 51
splenomegaly 45
back pain 44
nausea and vomiting 39
anesthesia 38
arthralgia 38
Ill 38
hepatomegaly 35
hypothermia 31
respiratory distress 27
sleepiness 25
hypotonia 25
cough 23
epigastric pain 21
asthenia 21
low back pain 20
erythema 18
chest pain 17
collapse 17
discomfort 16
renal colic 16
discomfort 16
myalgia 16
consciousness disturbance 16
flank pain 13
dizziness 13
shortness of breath 12
decreased appetite 12
abdominal discomfort 12
oliguria 12
analgesia 11
numbness 11
paresis 10
tremor 10
ataxia 10
night sweats 10
hip pain 10
paresthesia 9
exhaustion 8
apathy 8
acute abdomen 7
pallor 7
flushing 7
phosphatemia 7
angina 7
thinning 7
skin irritation 6
cancer pain 6
paraparesis 6
hoarseness 6
lassitude 6
spasm 6
agitation 6
Gastrointestinal symptoms 5
vertigo 5
emaciation 5
knee pain 5
shoulder pain 5
dry skin 5
insomnia 5
hemiplegia 5
hemoptysis 5
tingling 5
more...
Drug
PTH 834
Dial 125
Dermatol 76
Cinacalcet 66
Nephron 60
Nephron 58
Zoledronic acid 57
CaCl2 55
CaCl2 54
CaCl2 54
APD 51
Zoledronic acid 42
Clodronate 39
Gallium nitrate 29
Denosumab 28
EHDP 24
Sevelamer 22
Cardiovasc 21
CSF 20
ROS 15
CTX 15
Teriparatide 15
MRC 14
Aredia 14
Prednisone 14
Lanthanum carbonate 14
Indomethacin 13
Gel 12
Calcipotriol 11
Albumin 11
Alfacalcidol 10
Prednisolone 10
Adriamycin 9
Calcium acetate 9
Salmon calcitonin 9
Sevelamer hydrochloride 9
CTX 9
Calcium acetate 9
IFN-gamma 9
CTX 8
Ibandronate 7
lactose 7
Vitamin A 7
G-CSF 6
Rocaltrol 6
Carbetimer 6
ENT 6
IL-2 6
Zemplar 6
Angiotensin II 5
lysine 5
Cinacalcet hydrochloride 5
EE2 5
IL-11 5
Bonefos 4
Infliximab 4
vitamin E 4
Bortezomib 4
Infliximab 4
Growth hormone 4
Growth hormone 4
Vitamin K 4
Ketoconazole 4
CAM 4
MAP 4
ADM 4
Serum albumin 3
EPI 3
DDAVP 3
ETA 3
Elcatonin 3
DDAVP 3
Docetaxel 3
Sodium nitroprusside 3
CPM 3
Paraffin 3
citric acid 3
Maxacalcitol 3
Monit 3
VCR 3
more...
Enzyme
alkaline phosphatase 381
adenylate cyclase 56
lactate dehydrogenase 53
renin 52
ACE 40
mitogen-activated protein kinase 34
ERK 31
MDP 25
ATPase 24
protein kinase 21
peroxidase 17
creatine kinase 15
focal adhesion kinase 15
alanine aminotransferase 14
lipase 13
phospholipase C 13
proteasome 13
reverse transcriptase 12
lysozyme 12
CD10 12
acid phosphatase 12
asparaginase 12
protein kinase C 12
caspase-3 10
aspartate aminotransferase 10
ADH 10
alcohol dehydrogenase 10
1-hydroxylase 9
luciferase 9
trypsin 8
enolase 8
prostaglandin synthetase 7
RNA polymerase 7
MEK 7
PARP 6
phosphodiesterase 6
APC 6
chloramphenicol acetyltransferase 6
MEKK1 5
catalase 5
gamma-glutamyl transpeptidase 5
calcineurin 5
cathepsin K 5
calcium pump 5
MIP 5
transcriptase 5
thrombin 5
RNase 4
P-glycoprotein 4
prostate-specific antigen 4
superoxide dismutase 4
phytase 4
thromboplastin 4
caspase-9 4
phytase 4
RNase 4
ornithine decarboxylase 3
chymotrypsin 3
MAP 3
phospholipase A2 3
granzyme B 3
DCF 3
cathepsin L 3
CYP3A4 3
CPM 3
TdT 2
glyceraldehyde-3-phosphate dehydrogenase 2
MAT 2
phosphatidylinositol 3-kinase 2
transglutaminase 2
PHT 2
collagenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
ACS 2
5'-nucleotidase 2
CD13 2
S1 nuclease 2
MAT 2
caspase-8 2
beta-glucuronidase 2
more...
Compound
calcium 4856
vitamin D 1382
Clin 1380
phosphate 920
Dec 763
phosphorus 535
creatinine 445
sodium 225
carbonate 215
Vitamin D 213
25-dihydroxycholecalciferol 205
DNA 184
water 147
cAMP 141
Dial 125
aluminum 124
AMP 114
His 102
acetate 98
glucose 93
potassium 92
nitrogen 85
Calcitonin 84
urea 78
HPT 58
CaCl2 55
Pamidronate 50
salt 49
nitrate 49
oxygen 41
EDTA 40
Paricalcitol 39
aldosterone 39
EDTA 39
oxalate 37
ethanol 35
Vitamin D3 35
TSH 33
NH2 33
Vitamin D3 31
Mg2+ 31
ACTH 30
PGE2 29
hydroxide 29
HNO3 29
retinoic acid 28
phosphoric acid 28
arginine 27
Lithium 27
Mithramycin 27
25-hydroxycholecalciferol 26
iron 25
sulfate 25
Cardiol 24
Thyroid 23
tyrosine 22
BMD 22
MDA 21
sodium chloride 18
TRH 18
hydrogen 18
Alendronate 17
Calcium carbonate 17
TNF 17
iodine 17
Alendronate 16
ALP 16
HCl 15
CTX 15
EHDP 15
ATP 14
Prednisone 14
CO2 14
Indomethacin 13
Estrogen 12
retinol 11
Estrogen 11
galactose 11
leucine 11
Sodium 11
more...