Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020437 (
hypercalcemia
)
10,293
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
parathyroid hormone
2143
PTH
818
parathyroid hormone-related protein
679
Sep
660
calcitonin
575
alkaline phosphatase
381
parathormone
306
She
266
chronic renal failure
243
calcium-sensing receptor
188
Parathyroid hormone
156
vitamin D receptor
148
Mol
147
albumin
131
AMP
112
osteocalcin
96
insulin
89
Calcitonin
85
cytokine
77
RANKL
71
MRI
70
CYP24A1
69
CaSR
68
non-Hodgkin's lymphoma
63
vasopressin
62
gastrin
61
HPT
58
FHH
57
adenylate cyclase
54
lymphoid
52
renin
52
serum albumin
51
GFR
51
IL-6
50
collagen
50
osteoprotegerin
49
cage
49
IgA
47
Pol
47
tumor necrosis factor
47
gut
46
interleukin-6
44
prolactin
43
calcium sensing receptor
42
lactate dehydrogenase
41
osteosarcoma
40
Gen
39
CD4
38
somatostatin
38
growth hormone
36
thyroid hormone
35
PTH/PTHrP
35
thymus
34
RANK
34
endoplasmic reticulum
33
IL-1
33
parafibromin
33
Walker
32
FGF23
31
reserved
30
ACTH
30
MEN1
30
interferon
29
G protein-coupled receptor
29
hemoglobin
29
glycoprotein
27
OCT
27
type I collagen
27
LDH
27
CD8
26
polypeptide
26
VDR
25
glucagon
25
tartrate-resistant acid phosphatase
25
MDP
25
collecting duct
24
amylase
24
p21
24
CDC73
23
serum protein
23
more...
Disease
hypercalcemia
10293
cancer
2022
hyperparathyroidism
1719
primary hyperparathyroidism
1638
tumor
1522
multiple myeloma
781
adenoma
777
carcinoma
652
osteoporosis
569
renal failure
514
metastases
511
bone disease
493
hypercalciuria
465
bone metastases
445
hyperphosphatemia
411
sarcoidosis
388
anemia
352
lymphoma
345
breast cancer
342
chronic renal failure
290
leukemia
279
nephrocalcinosis
259
renal disease
257
hypoparathyroidism
250
hypertension
238
renal insufficiency
219
hypercalcemia of malignancy
195
lymphadenopathy
186
multiple endocrine neoplasia
185
nephrolithiasis
174
PDB
165
vitamin D deficiency
161
diabetes
158
Parathyroid carcinoma
158
squamous cell carcinoma
151
acute renal failure
147
pancreatitis
146
Parathyroid
145
osteomalacia
133
adult T-cell leukemia/lymphoma
133
spinal cord compression
133
adenocarcinoma
123
dehydration
122
acute pancreatitis
121
hyperthyroidism
110
paraneoplastic syndrome
109
prostate cancer
109
rickets
109
tuberculosis
106
renal impairment
105
parathyroid hyperplasia
99
renal osteodystrophy
98
lung cancer
98
proteinuria
94
tumor growth
92
Williams syndrome
91
renal cell carcinoma
90
hypoglycemia
88
osteitis
87
depression
80
hypervitaminosis
80
thrombocytopenia
80
pathological fracture
79
cardiovascular disease
72
calcinosis
71
uremia
70
non-Hodgkin's lymphoma
69
urolithiasis
68
Hodgkin's disease
67
confusion
66
hypothyroidism
66
acute lymphoblastic leukemia
63
MEN1
62
amyloidosis
60
primary tumor
60
psoriasis
60
Secondary hyperparathyroidism
58
Burnett
58
B-cell lymphoma
57
coma
56
more...
Symptom
pain
370
bone pain
326
vomiting
187
weakness
155
polyuria
147
nausea
144
anorexia
143
fatigue
137
lethargy
90
polydipsia
90
diarrhea
87
abdominal pain
86
constipation
84
cachexia
64
seizures
61
hepatosplenomegaly
56
headache
53
dyspnea
51
splenomegaly
45
back pain
44
nausea and vomiting
39
anesthesia
38
arthralgia
38
Ill
38
hepatomegaly
35
hypothermia
31
respiratory distress
27
sleepiness
25
hypotonia
25
cough
23
epigastric pain
21
asthenia
21
low back pain
20
erythema
18
chest pain
17
collapse
17
discomfort
16
renal colic
16
discomfort
16
myalgia
16
consciousness disturbance
16
flank pain
13
dizziness
13
shortness of breath
12
decreased appetite
12
abdominal discomfort
12
oliguria
12
analgesia
11
numbness
11
paresis
10
tremor
10
ataxia
10
night sweats
10
hip pain
10
paresthesia
9
exhaustion
8
apathy
8
acute abdomen
7
pallor
7
flushing
7
phosphatemia
7
angina
7
thinning
7
skin irritation
6
cancer pain
6
paraparesis
6
hoarseness
6
lassitude
6
spasm
6
agitation
6
Gastrointestinal symptoms
5
vertigo
5
emaciation
5
knee pain
5
shoulder pain
5
dry skin
5
insomnia
5
hemiplegia
5
hemoptysis
5
tingling
5
more...
Drug
PTH
834
Dial
125
Dermatol
76
Cinacalcet
66
Nephron
60
Nephron
58
Zoledronic acid
57
CaCl2
55
CaCl2
54
CaCl2
54
APD
51
Zoledronic acid
42
Clodronate
39
Gallium nitrate
29
Denosumab
28
EHDP
24
Sevelamer
22
Cardiovasc
21
CSF
20
ROS
15
CTX
15
Teriparatide
15
MRC
14
Aredia
14
Prednisone
14
Lanthanum carbonate
14
Indomethacin
13
Gel
12
Calcipotriol
11
Albumin
11
Alfacalcidol
10
Prednisolone
10
Adriamycin
9
Calcium acetate
9
Salmon calcitonin
9
Sevelamer hydrochloride
9
CTX
9
Calcium acetate
9
IFN-gamma
9
CTX
8
Ibandronate
7
lactose
7
Vitamin A
7
G-CSF
6
Rocaltrol
6
Carbetimer
6
ENT
6
IL-2
6
Zemplar
6
Angiotensin II
5
lysine
5
Cinacalcet hydrochloride
5
EE2
5
IL-11
5
Bonefos
4
Infliximab
4
vitamin E
4
Bortezomib
4
Infliximab
4
Growth hormone
4
Growth hormone
4
Vitamin K
4
Ketoconazole
4
CAM
4
MAP
4
ADM
4
Serum albumin
3
EPI
3
DDAVP
3
ETA
3
Elcatonin
3
DDAVP
3
Docetaxel
3
Sodium nitroprusside
3
CPM
3
Paraffin
3
citric acid
3
Maxacalcitol
3
Monit
3
VCR
3
more...
Enzyme
alkaline phosphatase
381
adenylate cyclase
56
lactate dehydrogenase
53
renin
52
ACE
40
mitogen-activated protein kinase
34
ERK
31
MDP
25
ATPase
24
protein kinase
21
peroxidase
17
creatine kinase
15
focal adhesion kinase
15
alanine aminotransferase
14
lipase
13
phospholipase C
13
proteasome
13
reverse transcriptase
12
lysozyme
12
CD10
12
acid phosphatase
12
asparaginase
12
protein kinase C
12
caspase-3
10
aspartate aminotransferase
10
ADH
10
alcohol dehydrogenase
10
1-hydroxylase
9
luciferase
9
trypsin
8
enolase
8
prostaglandin synthetase
7
RNA polymerase
7
MEK
7
PARP
6
phosphodiesterase
6
APC
6
chloramphenicol acetyltransferase
6
MEKK1
5
catalase
5
gamma-glutamyl transpeptidase
5
calcineurin
5
cathepsin K
5
calcium pump
5
MIP
5
transcriptase
5
thrombin
5
RNase
4
P-glycoprotein
4
prostate-specific antigen
4
superoxide dismutase
4
phytase
4
thromboplastin
4
caspase-9
4
phytase
4
RNase
4
ornithine decarboxylase
3
chymotrypsin
3
MAP
3
phospholipase A2
3
granzyme B
3
DCF
3
cathepsin L
3
CYP3A4
3
CPM
3
TdT
2
glyceraldehyde-3-phosphate dehydrogenase
2
MAT
2
phosphatidylinositol 3-kinase
2
transglutaminase
2
PHT
2
collagenase
2
glyceraldehyde-3-phosphate dehydrogenase
2
ACS
2
5'-nucleotidase
2
CD13
2
S1 nuclease
2
MAT
2
caspase-8
2
beta-glucuronidase
2
more...
Compound
calcium
4856
vitamin D
1382
Clin
1380
phosphate
920
Dec
763
phosphorus
535
creatinine
445
sodium
225
carbonate
215
Vitamin D
213
25-dihydroxycholecalciferol
205
DNA
184
water
147
cAMP
141
Dial
125
aluminum
124
AMP
114
His
102
acetate
98
glucose
93
potassium
92
nitrogen
85
Calcitonin
84
urea
78
HPT
58
CaCl2
55
Pamidronate
50
salt
49
nitrate
49
oxygen
41
EDTA
40
Paricalcitol
39
aldosterone
39
EDTA
39
oxalate
37
ethanol
35
Vitamin D3
35
TSH
33
NH2
33
Vitamin D3
31
Mg2+
31
ACTH
30
PGE2
29
hydroxide
29
HNO3
29
retinoic acid
28
phosphoric acid
28
arginine
27
Lithium
27
Mithramycin
27
25-hydroxycholecalciferol
26
iron
25
sulfate
25
Cardiol
24
Thyroid
23
tyrosine
22
BMD
22
MDA
21
sodium chloride
18
TRH
18
hydrogen
18
Alendronate
17
Calcium carbonate
17
TNF
17
iodine
17
Alendronate
16
ALP
16
HCl
15
CTX
15
EHDP
15
ATP
14
Prednisone
14
CO2
14
Indomethacin
13
Estrogen
12
retinol
11
Estrogen
11
galactose
11
leucine
11
Sodium
11
more...