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Target Concepts:
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Query: UMLS:C0020437 (
hypercalcemia
)
10,293
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A term infant developed subcutaneous fat necrosis of the newborn (SFNN) 17 days following completion of therapeutic
hypothermia
for hypoxic ischaemic encephalopathy. Initial calcium was normal, however
hypercalcaemia
requiring hyperhydration and furosemide developed at 4 weeks. Parathyroid hormone and vitamin D were suppressed. At 13 months, she remains on low calcium formula, and has gross motor delay, central hypotonia and early hand preference. Review of 102 articles yielded 119 SFNN cases. Asphyxia was reported in 78%. Twenty-one per cent had hypoglycaemia. Twenty per cent underwent therapeutic
hypothermia
. Median onset of skin lesions was day 6 (range: 1-70), with a median duration of 62 days (range: 14-390).
Hypercalcaemia
developed in 53% (median onset day 28, range: 1-210). Fifty-two per cent of
hypercalcaemia
was asymptomatic. Outcome information was provided in 106/119 cases; 87% reported a full resolution. Persistent calcinosis was present in 6%. Babies treated with therapeutic
hypothermia
should be closely monitored for SFNN, and development of
hypercalcaemia
.
...
PMID:Subcutaneous fat necrosis of the newborn. 3184 70
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