Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020175 (hunger)
 5,670 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Varied clinical observations of the presence of either hunger or anorexia during intragastric or intravenous alimentation have led to the current experiments. Nine rhesus monkeys (Macaca mulatta) were involved in studies of the long-term effects of enteral and parenteral nutrition on appetite as assessed by feeding behavior and gastric motility. The monkeys received either intragastric infusions of glucose or a complete liquid diet, or intravenous infusions of glucose or glucose/amino acid solutions. Oral intake was accurately adjusted to account for the calories administered by the intragastric route. Oral intake was also reduced in a calorically equivalent amount to account for the calories received during intravenous glucose. When glucose/amino acid solutions were administered parenterally, adjustments were less accurate, with resultant overeating and weight gain in some monkeys during parenteral nutrition, followed by prolonged suppression of appetite after cessation of the infusions. Further studies of the effects of varied compositions of parenteral nutrition, and varied methods of weaning from infusions, are indicated.
 ...
PMID:Effects of enteral and parenteral nutrition on appetite in monkeys. 9 52

Major phases of the physiology of food intake regulation remain hypothetical. There is a central regulatory mechanism for hunger and satiety, but the signals and messages that activate the brain centers remain conjectural. The alimentary tract regulation, the regulation by osmoreceptors, the thermostatic, the glucostatic, the lipostatic, the amino acid, and the hormonal food intake regulation theories leave many questions unanswered. Low molecular weight peptides appear to have an important effect on brain functions. Hypothalamic peptides such as thyrotropin-releasing hormone, gonadotropin-releasing hormone, and somatostatin have been assigned new roles in various brain functions. The hypothalamus and probably other parts of the brain produce also anorexigenic peptides. Anorexia is a common manifestation of cancer. It is proposed that peptides, oligonucleotides, and other small metabolites produced by the cancer and by the tumor-bearing host are responsible for the genesis of the anorexia. They produce the anorexia through a peripheral effect on neuroendocrine cells and neuroreceptors and through a direct effect on hypothalamic and other central nervous system sensor and responder cells.
 ...
PMID:Anorexia-producing intermediary metabolites. 17 68

Rats that were made diabetic by the subcutaneous injection of alloxan monohydrate were found to be resistant to the anorexic action of d-amphetamine. This resistance to amphetamine anorexia did not appear attributable to an increased hunger motivation of the diabetic rats, but rather seemed due to a diminished action of the drug in alloxan-injected animals. This conclusion was supported by further experiments indicating that alloxan-injected rats show diminished locomotor activity and stereotyped behavior following amphetamine administration. Furthermore, the amphetamine resistance appears to be the result of the diabetic state, since amphetamine-induced stereotyped behavior could be reinstated in alloxan-injected rats by the administration of protamine zinc insulin for ten days. The results of these investigations suggest that there exists an altered central nervous system response to d-amphetamine in the diabetic rat. These possibility of an abnormal functioning of central catecholamine-containing neurons in such animals is discussed.
 ...
PMID:Further analysis of the resistance of the diabetic rat to d-amphetamine. 56 33

Very fat people die earlier than people of normal weight because hypertension, diabetes and coronary disease are more frequent among the markedly obese. Most obese subjects, however, are only slightly overweight and their mortality is not elevated. Reasons for dieting are more often psychological than somatic. 2. Reducing diets are ineffective because the obese rarely follow them. Total fasting and intestinal bypass may provide better results, but are more dangerous. 3. Atkins' diet eliminates carbohydrates from food without restricting protein and fat intake. Deprived of carbohydrates, the body uses fat for fuel. A small part of metabolized fat is eliminated in the urine as ketone bodies, and this is why such diets are called "ketogenic". They have been known at least since 1863. 4. Caloric loss due to ketonuria does not exceed 100 Cal/day in the non-diabetic. It is maximal during total fasting and cannot be increased by a ketogenic diet. 5. In the short run, such diets produce rapid weight loss due to polyuria. On the other hand, refeeding carbohydrates causes water retention and weight gain. 6. The diet decreases appetite: patients eat less without feeling severe hunger and without measuring their food intake. 7. Orthostatic hypotension, fatigue, and nausea are frequent, despite what Dr. ATKINS claims. 8. The diet increases plasma cholesterol and uric acid. It may be dangerous in diabetes (anorexia, acidosis) and in heart or kidney failure (hypokalemia). 9. The diet, though far from good, is better than the book. ATKINS' theories are at best half-truths, and the results he claims lack credibility. The obese subject's disappointment with traditional reducing diets and the book's hard-sell style account for ATKINS' success.
 ...
PMID:[Dr. Atkins' dietetic revolution: a critique]. 89 45

Hunger and fullness during an experimental liquid meal were evaluated by ratings in 84 eating-disordered patients, including three diagnostic subgroups, and in 19 controls who were normal in weight and eating healthily. Anorectic-restrictors had lower hunger ratings and higher fullness ratings than controls. The same tendency was present in anorectic-bulimics. These ratings were relatively unaffected by treatment. Anorectic-restrictors had longer meals than the anorectic-bulimics and normal-weight bulimics. The anorectic-restrictors also tended to eat more slowly than did the bulimic patients. These groups did not, however, differ in amount consumed. At the end of the experimental meal, the anorectic-bulimics were more preoccupied with thoughts of food and anorectic-restrictors had a lower urge to eat, as compared with the controls. Hunger and fullness ratings were negatively correlated for all diagnostic groups; however, these correlations were less pronounced for the eating disorder groups. The eating-disordered patients had predominantly "abnormal" patterns of hunger and fullness curves, indicating a confusion of these concepts.
 ...
PMID:Temporal patterns of hunger and fullness ratings and related cognitions in anorexia and bulimia. 188 49

It is relatively easy to demonstrate drug-induced anorexia in animals, but the significance of-such suppression of eating is often doubtful. Of the many agents shown to be 'active' in animals, only a very few are genuine appetite suppressants with clinical potential. Drugs that increase central 5-HT levels, or that activate peripherally acting peptides, are currently among the most promising candidates. John Blundell advocates a systems approach to the study of appetite control. Drug-induced changes in feeding should be interpreted according to a system which involves behaviour, peripheral physiology and brain neural pathways. Appetite involves more than alterations of food intake; the concept should take into account changes in hunger, food preferences, responses to taste and changes in macronutrient preferences.
 ...
PMID:Pharmacological approaches to appetite suppression. 206 81

A psychometric analysis of the Rigorous Eating Scale was carried out based on data of Smead from 1986 and also from 1987 by Smead and Boyd. This 13-item scale was designed to measure hunger, deprivation, and restraint in eating style and used in both of the foregoing studies to investigate the relationship between dieting and eating style and scoring higher on measures of subclinical symptoms of anorexia and bulimia. This brief report highlights internal consistency reliability, factor structure, and item-criterion correlations. Results indicate appropriately high reliability, but inadequate factor structure. Item-criterion correlations suggest several aspects of eating style which may be important to include in similar scales of the future.
 ...
PMID:A psychometric investigation of the Rigorous Eating Scale. 226 9

Since 1958 we have conducted a prospective study of anorexia/bulimia nervosa (A/BN) covering a total of 550 patients. This paper presents a new idea of the development of A/BN. For a variety of reasons, a predisposition for developing A/BN is triggered by a minor and non-specific loss of weight. The development of mental symptoms with pathological thoughts and behaviour, and disturbances in the satiety and hunger centres suggest a cerebral dysfunction. Educating patients in pathophysiology enables them to use their intelligence, logical thinking and strong will to evaluate the importance of an adequate supply of nutrients. To date, two studies of the outcome of the disease have been carried out producing similar results: 86% fair results (12% spontaneous recovery), 13% chronic cases and 1% have died.
 ...
PMID:Anorexia/bulimia nervosa: the development of anorexia nervosa and of mental symptoms. Treatment and the outcome of the disease. 229 29

The present studies concerned a perceptual mechanism that could partially explain the anorexic's severe eating restraint despite continuing hunger. If a woman values a thin body, unrealistic perception of food's fattening effects should increase the aversiveness of ingesting food and foster restraint in eating. The first study considered the perceived thinness/fatness of women's bodies without and with food cues present. College women who (1) shared the stress-generating personality characteristics of anorexics (AP); and (2) judged models as fatter after food cues were introduced (enhancers) reported more stress than AP non-enhancers; no effect of enhancement upon stress was observed in controls. This moderator effect was replicated in a second study. Thus, women with the personality characteristics and high stress that put them at-risk for anorexia also displayed the perceptual distortion involved in the proposed mechanism. Self-ratings verified the same perceptual mechanism in the high-stress AP woman's perception of her own body.
 ...
PMID:Food cues and perceptual distortion of the female body: implications for food avoidance in the early dynamics of anorexia nervosa. 261 92

Studies indicate that hypothalamic monoamine systems involved in the control of food intake have specific effects on temporal feeding patterns and on appetite for specific macronutrients. Based on the evidence obtained in rats, it is proposed that serotonin acts, in part, through a satiety mechanism of the medial hypothalamus, to reduce ingestion of carbohydrate while sparing protein intake. In controlling the ratio of carbohydrate to protein intake, this serotonergic system, which is responsive to the anorectic agent fenfluramine, is believed to function in direct opposition to the alpha 2-noradrenergic system of the paraventricular nucleus, which inhibits satiety for carbohydrate and thereby potentiates the size of carbohydrate meals. This serotonergic system may also indirectly oppose the catecholaminergic systems of the lateral hypothalamus, which mediate amphetamine anorexia and which inhibit a hunger-stimulating system for protein intake, thereby delaying the initiation of protein meals. Examination of the rats' normal eating patterns, in conjunction with particular biochemical analyses, has indicated specific points in the circadian eating cycle where these hypothalamic monoamine systems, in association with changes in circulating hormones and nutrients, may be physiologically activated.
 ...
PMID:Brain serotonin and eating behavior. 287 68


1 2 3 4 5 6 7 8 9 10 Next >>