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Query: UMLS:C0020175 (hunger)
 5,670 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author discusses Freudian dualistic conception of drives and contends that it can be reduced to a monistic one, on the basis of modern conceptions of Biology, and after scanning the original writings of Freud on the subject of drive and instinct. The word Trieb (drive) is used by Freud as compared with Instinkt (instinct); in 1915 the concept is defined through its attributes: thrust, source, objet and goal; being object and goal contingent for the drive and fixed for instincts. The first dualism is love vs. hunger; the drives are either sexual or autoconservative. But Biology demonstrates today that all life movements are autoconservative. The second dualism, love vs. hate, and the third one, Eros vs. Thantos, interpreted through Biology, show that there is always a prevailing therm, the first one. In this view, instinct should be but one successful drive, "frozen" through time because of its very success, and transmitted through philogenetic channels, in order to be enlivened in each ontogenetic process.
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PMID:[The Dualism drive in Freudian theory]. 76 66

Our investigation was designed to retest the hypothesis of the efficacy of human chorionic gonadotropin (HCG) on weight reduction in obese women in a clinic setting. We sought to duplicate the Asher-Harper study (1973) which had found that the combination of 500 cal diet and HCG had a statistically significant benefit over the diet and placebo combination as evidenced by greater weight loss and decrease in hunger. Fifty-one women between the ages of 18 and 60 participated in our 32-day prospective, randomized, double-blind comparison of HCG versus placebo. Each patient was given the same diet (the one prescribed in the Asher-Harper study), was weighed daily Monday through Saturday and was counselled by one of the investigators who administered the injections. Laboratory studies were performed at the time of initial physical examinations and at the end of the study. Twenty of 25 in the HCG and 21 of 26 patients in the placebo groups completed 28 injections. There was no statistically significant difference in the means of the two groups in number of injections received, weight loss, percent of weight loss, hip and waist circumference, weight loss per injections, or in hunger ratings. HCG does not appear to enhance the effectiveness of a rigidly imposed regimen for weight reduction.
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PMID:Ineffectiveness of human chorionic gonadotropin in weight reduction: a double-blind study. 78 1

A squirrel monkey, if it needs a particular dietary component because of a metabolic disorder or because that food has been excluded from its diet, will develop a specific hunger for the food. In cases where specific hungers show up clearly, four behaviors can be demonstrated: (1) The monkey prefers the food it needs to other foods that are also available; (2) It usually ingests large amounts of the food to meet its particular physiological requirements; (3) The animal will tend to eat the needed food even while the stomach is full; (4) When vitamin B2 is removed from its diet, a squirrel monkey will exhibit digestive disturbance, general weakness, a lack of vigor, and loss of weight.
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PMID:Experimental studies of food selective behavior in squirrel monkeys fed on riboflavin deficient diet. 81 66

Electrical stimulation of medial hypothalamic and ventromedial hypothalamic areas of the cat brain stops the initiation of spontaneous predatory attack in cats, confirming similar evidence of other investigators. Furthermore, a new attack suppressing area, the mammillary bodies, was uncovered. Facilitation of predatory attack by hunger raised the electrical threshold for attack in the mammillary bodies. In addition, baseline levels of neural activity in attack suppressing brain areas prior to any brain stimulation were found to decrease when the cats were hungry and killing was facilitated and neural activity increased when the cats were on ad lib. feeding. These data support the hypothesis that modulation of excitability of neural systems functioning to suppress is involved in facilitation of attack behavior by hunger.
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PMID:Hypothalamic and extrahypothalamic substrates of predatory attack. Suppression and the influence of hunger. 81 84

An account is given of the fundamental mechanisms concerned with the regulation of hunger and thirst, and of the physiological processes involved in the uptake of nutrients, water and electrolytes. Several reflex chains ensure that the organism does not take up too much water and also protect it from excessive loss of water and salt.
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PMID:[Physiological equilibration of water, electrolytes and nutrients]. 82 1

Insulin, a primary metabolic hormone, plays a dominant role in the regulation of food intake. An increase in the level of circulating insulin produced by its prandial release from endogenous stores is associated with the state of satiety. On the other hand, an increase in the insulin level produced by its exogenous administration, as well as by its excessive and prolonged release in certain pathological states or during the period of nocturnal overeating, paradoxically gives rise to the sensation of hunger. This differential effect of endogenous and exogenous insulin is analyzed in view of experimental and clinical evidence concerning the principal mechanisms in the regulation of food intake. These include the interrelation of central and peripheral glucosensitive systems, the involvement of the enteroinsular axis, and the effects on these regulatory mechanisms of the physiological state produced by changes in circulating insulin levels. The essential role of the vagus nerve in mediating the hunger and satiety induced by the lack of excess of glucose for cellular oxidation places the short-term glucostatic control in the periphery where the insulin is primarily acting. A unifying hypothesis concerning the role of insulin in the regulation of good intake is proposed and its clinical implications suggested.
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PMID:The role of insulin in the glucostatic control of food intake. 82 7

Four adolescents or young adults with the Prader-Willi syndrome (hypotonia, mental retardation, hypogonadism and obesity) received a protein-sparing modified fast consisting of 1.5 g of meat protein per kilogram of ideal body weight and meeting vitamin, mineral and fluid requirements. Evaluation of nitrogen and energy metabolism revealed the development of starvation ketosis and a positive nitrogen balance. Serial whole-body potassium measurements in two patients confirmed preservation of lean tissue despite continuing loss of weight. Clinical diabetes mellitus in two subjects was rapidly ameliorated by the regimen. Short-term weight loss greater than 18 kg occurred in three of the four subjects, and reduced weight persisted during observation periods of 26 to 44 months. This degree of outpatient diet adherence by mentally deficient subjects, who do not normally experience satiety, suggests that hunger is eliminated or at least reduced by modified, protein-sparing fasting.
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PMID:Metabolic aspects of a protein-sparing modified fast in the dietary management of Prader-Willi obesity. 84 Feb 78

In addition to established gastrointestinal hormones--secretin, cholecystokinin-pancreozymin (CCK-PZ), gastrin, and glucagon---some 30 polypeptides with gastrointestinal actions can be listed. New aspects of these substances include the following: Gastrin and vasoactive intestinal peptide (VIP) can be also encountered in the central nervous system and may act as transmitters. CCK-PZ-serum concentrations are found markedly elevated in patients with exocrine pancreatic insufficiency; this may provide the opportunity to establish a realtively simple screening test. Moreover, there is evidence that serum-CCK-PZ levels serve as satiety signal. Secretin secretion is said to be enhanced in hunger and then to act as a lipolytic hormone. In addition to enteroglucagon, a gastrintestinal peptide identical to pancreatic glucagon has been detected. Gastric inhibitory polypeptide (GIP) inhibits gastric secretion and motility (enterogastrone activity) and together with glucose it stimulates insulin release (incretin activity). Motilin increases lower esophageal sphincter pressure, enhances gastric pepsin secretion and slows down gastric evacuation. Serum levels of pancreatic polypeptide may be found elevated as a diagnostic index in patients with endocrine peptide tumors of the pancreas. Recently, the potential importance of local (paracrine) actions of gastrointestinal polypeptides has been amphasized. Predominantly paracrine activity is exhibited by some prototype hormones, e.g. somatostatin, substance P, bombesian, and the non-polypeptide compounds, prostaglandins.
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PMID:[New views on gastrointestinal hormones]. 85 99

1. Rats were undernourished in early life by feeding their mothers a restricted quantity of a good-quality diet throughout lactation. Their undernutrition continued postweaning from 25 to 42 d of age, after which they were fed ad lib. Control rats were well nourished at all times. 2. Behavioural assessment of thirst was carried out on adult males. These were deprived of water for 23 h/d throughout the period of testing. Compared to control rats, previously-undernourished (PU) rats pressed a lever at a higher rate in a Skinner box to gain a water reward, drank more frequently during their first 5 min in an unfamiliar cage, and tended to run more quickly down an alleyway for water. PU rats also drank more (/kg body-weight 0-75) of a quinine solution (I g/l) when this was available to them ad lib. as their only source of fluid. 3. A second group of rats was growth-retarded during gestation and the suckling and early postweaning periods. The rats had free access to food from 42 d of age. In adulthood their ad lib. food and water consumption was measured. PU males ate and drank more (/kg body-weight 0-75) than control males. 4. These results indicate that adult rats which have been undernourished in early life display increased thirst. An attempt is made to explain this finding, together with their previously-demonstrated enhanced hunger drive, purely in terms of gross anatomical and physiological differences.
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PMID:Increased thirst and hunger in adult rats undernourished as infants: an alternative explanation. 86 Nov 92

Four cases of combined pharyngeal and esophageal stricture were managed by pharyngogastrostomy 4 months to 42 years after injury. The stomach was brought up to the neck via the posterior mediastinum after the esophagectomy. A thoracotomy was not used. The results were suprisingly good in 3 patients followed to 3 years. A fourth patient died 6 months after the operation. In those patients benefiting from the operation, regurgitation was minimal when a few precautions were observed. The patients have normal hunger pains and appetite. They are able to eat a full-sized meal. The advantages of stomach compared to colon replacement of the esophagus are discussed.
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PMID:Pharyngogastrostomy for treatment of severe caustic stricture of the pharynx and esophagus. 87 Jul 63


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