Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019829 (Hodgkin's disease)
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Human Gene/Protein
CYCLIN K 10.0
homeo box A3 10.0
Kruppel-type zinc-finger protein 10.0
PPI5PIV 10.0
cell division cycle 2-like 1 10.0
Caspase recruitment domain-containing protein 14 10.0
LRP5L 10.0
Protein tyrosine phosphatase, non-receptor type 6 10.0
TCL3 oncogene 10.0
NBPF8 10.0
FAM82A2 10.0
KLHDC8B 9.8
NOVP 9.3
CD30 antigen 9.1
C14orf43 9.0
ORC4L 9.0
INE1 9.0
HOMEZ 9.0
NNX3 9.0
TRD@ 9.0
ZBTB44 9.0
MKL1 protein 9.0
ANGPT3 9.0
TRAF5 protein 9.0
FTHFD 9.0
EMLP 9.0
Ki-1/57 9.0
REL protein 8.7
NHL 8.7
Ki-1 antigen 8.7
HD9 8.7
Ki-1 8.5
CD30 8.5
N4BP2 8.5
ATRNL1 8.5
Myeloid cell nuclear differentiation antigen 8.5
Kruppel-type zinc finger protein 8.5
THUMPD3 8.5
ACTR3B 8.5
CD99 antigen-like 2 8.5
FVT-1 8.5
C14orf101 8.5
IgG VH 8.5
MEF2B protein 8.5
UNC84B 8.5
HGAL 8.4
CD30 ligand 8.3
CD58 protein 8.2
RMD-1 8.2
OCT-2 8.2
Ly110 8.0
IBtk 8.0
CD22 protein 8.0
Ran-GTP binding protein 8.0
melanoma associated antigen (mutated) 1 8.0
PR domain containing 1, with ZNF domain 8.0
xeroderma pigmentosum, complementation group G 8.0
CCDC91 8.0
BCL2/JH 8.0
C2TA 8.0
GNT-V 8.0
interferon induced transmembrane protein 1 8.0
SCLL 8.0
Cytoplasmic FMR1-interacting protein 2 8.0
PAX-5 8.0
NKX6.3 7.9
nuclear interaction partner of ALK 7.9
GCET1 7.9
CD37 antigen 7.9
BOB 7.8
histone deacetylase 10 7.8
non-Hodgkin's lymphoma 7.8
restin 7.8
BCL-6 7.7
COL29A1 7.7
Ke-Oz- 7.7
BCL8 7.7
THAP4 7.7
NME6 7.7
ubiquitously transcribed tetratricopeptide repeat, X chromosome 7.7
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Disease
Acquired hemoglobinopathy 10.0
NK-cell lymphoblastic lymphoma 10.0
Mature B-Cell Lymphoma 10.0
T-cell rich large B-cell lymphoma 10.0
Hodgkin's disease 10.0
Hodgkin's paragranuloma 10.0
Mediastinal disease 10.0
Mediastinal large B-cell lymphoma 10.0
stage, hairy cell leukemia 10.0
Lymphoplasmacytoid immunocytoma 10.0
EEC3 10.0
Lymphosarcoma and reticulosarcoma 10.0
Intra-abdominal lymph nodes 10.0
SALT lymphoma 10.0
stage I non-Hodgkin's lymphoma 10.0
Hodgkin's disease with lymphocytic predominance 9.8
Mixed cellularity 9.8
cHL 9.8
AIDS-related Hodgkin's disease 9.7
NLPHL 9.6
NSHL 9.6
AIDS-related diffuse large cell lymphoma 9.5
stage IV Hodgkin's disease 9.4
Hodgkin-like PTLD 9.3
CB/CC 9.2
Hodgkin's disease stage I 9.1
Primary mediastinal large B-cell lymphoma 9.1
pediatric HD 9.1
neoplasm remission 9.0
Malignant lymphoma of bone 9.0
Localized nodular myositis 9.0
stage II non-Hodgkin's lymphoma 9.0
AIDS-related small noncleaved cell lymphoma 9.0
Head, face and neck 9.0
childhood leiomyosarcoma 9.0
Hodgkin Lymphoma PTLD 9.0
Precursor B-lymphoblastic lymphomas 9.0
Herpetic iritis 9.0
Gingival ulceration 9.0
Progressively transformed germinal centers 9.0
Pulmonitis 9.0
Monoclonal hypergammaglobulinemia 9.0
childhood NHL 9.0
adult NHL 9.0
Composite lymphoma 9.0
relapsed small lymphocytic lymphoma 8.9
Hodgkin's disease during pregnancy 8.8
Hodgkin's-like 8.8
intermediate-grade lymphomas 8.7
recurrent mantle cell lymphoma 8.7
NHL 8.7
Vanishing bile duct syndrome 8.6
Lennert's lymphoma 8.6
Precursor B-cell lymphoblastic lymphoma 8.6
high-grade lymphomas 8.5
Small non-cleaved cell lymphoma 8.5
pleurorrhea 8.5
Asteatosis 8.5
Mantle zone lymphoma 8.5
Polymorphic PTLD 8.5
adult HD 8.5
ALKoma 8.5
B-cell lymphoblastic lymphoma/leukemia 8.5
Idiopathic Hypersomnia 8.5
Peripheral sensorimotor neuropathy 8.5
Minimal change glomerulonephritis 8.5
Lymphoblastic lymphoma 8.4
stage III Hodgkin's disease 8.4
Centroblastic 8.3
Splenic lymphoma 8.3
Hodgkin's disease refractory 8.3
T/NK-cell lymphoma 8.3
Lymphocytic lymphoma 8.2
childhood lymphoblastic lymphoma 8.2
Intestinal lymphoma 8.2
Richter's syndrome 8.2
low-grade lymphomas 8.2
anaplastic large cell lymphoma 8.2
immunocytoma 8.1
small lymphocytic lymphoma 8.1
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Symptom
gas pain 9.0
No respiratory symptoms 8.0
Generalized urticaria 7.7
Nausea, vomiting and diarrhea 7.5
Generalized fatigue 7.5
Halo sign 6.9
Truncal ataxia 6.7
Cutaneous anergy 6.7
Globus sensation 6.6
Excitable 6.2
febricula 6.1
feeling exhausted 6.1
night sweats 6.1
Thoracic pain 5.7
enanthema 5.3
Beau's lines 5.3
difficulty with urination 5.3
brittle nails 5.0
Koplik spots 4.7
Lhermitte's sign 4.7
hepatosplenomegaly 4.6
Urticarial vasculitis 4.6
non-productive cough 4.5
generalized rash 4.5
epigastric distress 4.5
fever of unknown origin 4.4
splenomegaly 4.4
polymyalgia 4.2
jaw pain 4.1
Neurologic symptoms 4.1
staggering gait 3.9
Urinary symptoms 3.8
anal pain 3.7
adenitis 3.7
Parkinsonian tremor 3.6
lumbar back pain 3.6
asthenia 3.6
orthopnea 3.5
arm weakness 3.5
hepatomegaly 3.5
abdominal fullness 3.4
Excitability 3.3
Visual symptoms 3.2
chills 3.2
bone pain 3.2
facial droop 3.1
pneumaturia 2.9
productive cough 2.9
dark urine 2.9
chromosome marker 2.9
persistent cough 2.8
right lower quadrant pain 2.8
nausea and vomiting 2.8
hoarseness 2.8
abdominal discomfort 2.7
iliac fossa pain 2.7
Severe pain 2.7
nausea 2.7
meningism 2.6
shortness of breath 2.6
precordial pain 2.6
clubbing 2.6
hypoproteinemia 2.5
nasal congestion 2.5
eye pain 2.5
rectal pain 2.5
dyspnea 2.4
paresthesia 2.4
dental pain 2.4
giddiness 2.4
giddiness 2.4
muscle stiffness 2.4
ENT 2.4
pallor 2.3
Cushingoid 2.3
inanition 2.2
leg edema 2.2
Cushingoid 2.2
vomiting 2.2
epigastric pain 2.2
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Drug
Iratumumab 9.0
Galiximab 8.7
Pixantrone 8.6
Mustargen 8.5
Lumiliximab 8.5
Apolizumab 8.5
Epratuzumab 8.3
Pralatrexate 7.9
Ibritumomab tiuxetan 7.7
Bexxar 7.6
Zevalin 7.6
Sobuzoxane 7.5
Lestaurtinib 7.3
Methotrexate sodium 7.2
Busulfex 7.2
Velban 6.8
Vindesine 6.7
Ontak 6.7
Ontak 6.7
Rituximab 6.6
Vindesine 6.6
Alferon N 6.6
Epidoxorubicin 6.3
Genasense 6.2
Novantrone 6.1
Bleomycins 6.0
Rasburicase 5.9
Romidepsin 5.8
Etoposide phosphate 5.8
Fludarabine 5.8
Lenalidomide 5.6
Edatrexate 5.6
Nipent 5.6
Leukine 5.6
Filgrastim 5.6
Wellferon 5.5
Forodesine 5.5
Revlimid 5.5
Filgrastim 5.5
VCR 5.5
Navelbine 5.3
Berberine chloride 5.3
Ferumoxtran-10 5.2
Prednisone 5.2
Freon 11 5.0
ProstaScint 5.0
Methotrexat 5.0
G-CSF 5.0
Adriamycin 4.9
Etoposide 4.7
Gallium nitrate 4.7
BLyS 4.7
Rasburicase 4.6
Vinorelbine 4.6
Bexarotene 4.6
MDS 4.6
Zofran 4.5
TRM 4.5
Paraffin 4.5
Teniposide 4.5
anti-CD33 4.5
Solon 4.4
Synthroid 4.4
Aprepitant 4.4
Idarubicin 4.3
Lenograstim 4.3
Tykerb 4.3
Bortezomib 4.3
Dexrazoxane 4.2
Zofran 4.2
L-Asparaginase 4.2
Chloramine T 4.2
Campath 4.2
Campath 4.2
Asparaginase 4.0
Clofarabine 3.9
VCR 3.9
Prednisolone 3.9
RBT 3.9
Vorinostat 3.9
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Enzyme
MT 1 6.4
L-phenylalanine oxidase 6.1
CAO 4.6
CD10 4.3
p80 4.3
DAP II 4.3
TdT 4.2
folylpolyglutamate synthetase 4.2
granzyme B 4.1
histone-lysine N-methyltransferase 4.0
BMT 4.0
nicotinic acid phosphoribosyltransferase 3.9
FucT 3.8
asparaginase 3.7
bleomycin hydrolase 3.7
endothiapepsin 3.5
caspase-10 3.5
STK2 3.5
caspase-10 3.5
phosphatidylinositol phospholipase C 3.4
p100 3.4
CEP 3.3
TSA 3.3
polyphosphatase 3.2
ricin 3.2
methylthioadenosine phosphorylase 3.2
purine nucleoside phosphorylase 3.0
riboflavin kinase 3.0
SRR 3.0
NOS 2.9
lactate dehydrogenase 2.8
CEP 2.7
inositol phosphatase 2.7
CPM 2.6
TSP-1 2.6
IKK 2.4
PFI 2.4
tetanus neurotoxin 2.4
phosphatidylinositol-4,5-bisphosphate 3-kinase 2.4
AAE 2.3
adenosine deaminase 2.3
NAT 2.3
lysophospholipase D 2.3
Alternating 2.2
focal adhesion kinase 2.2
adenosine deaminase 2.2
LPL 2.2
lactic acid dehydrogenase 2.2
inositol 3-kinase 2.2
15-lipoxygenase 2.2
lactic acid dehydrogenase 2.1
cathepsin S 2.1
asparagine synthetase 2.1
caspase-1 2.1
acid phosphatase 1.9
serine hydroxymethyltransferase 1.8
lysozyme 1.8
EPT 1.8
ERK 1.8
ceruloplasmin 1.8
MDP 1.8
LTA4 hydrolase 1.8
uricase 1.8
tryptase 1.8
thymidine kinase 1.7
histone demethylase 1.7
CD13 1.7
dipeptidyl peptidase IV 1.7
GMT 1.6
PDH 1.6
ADP-ribosyltransferase 1.6
PNL 1.6
topoisomerase 1.6
proteinase-3 1.6
thymidine phosphorylase 1.6
farnesyltransferase 1.6
ADP-ribosyltransferase 1.6
deoxycytidine kinase 1.6
topoisomerase 1.6
methylenetetrahydrofolate reductase 1.6
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Compound
2-aminoheptanedioic acid 10.0
Trimethylcolchicinic acid methyl ether 9.0
AD-143 9.0
Asaley 9.0
N-octylguanidine 8.5
QYNAD 8.0
Procarbazine 7.8
D 43 7.7
6-Ketocholestanol 7.7
Cytostasan 7.7
Prednimustine 7.5
Mechlorethamine 7.4
Nodular 7.3
Sarcolysine 7.2
5-chloro-2-hydroxybenzoic acid 7.2
DHAC 7.0
IVE 7.0
AHCT 7.0
Velban 6.9
PHPS 6.9
3-Methylxanthine 6.9
DMBC 6.7
Lycurim 6.7
Glycylproline 6.5
Butanal 6.3
LCR 6.3
Fludarabine phosphate 6.2
methyl octanoate 6.1
Imexon 6.1
CCNU 6.1
MB 1 6.0
TMCA 6.0
CD 3 6.0
IEA 5.8
TMCA 5.7
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde 5.7
BCNU 5.7
Chlorambucil 5.7
Vinblastine 5.7
SLEX 5.6
Vincristine 5.5
Temsirolimus 5.5
Narciclasine 5.5
INa 5.4
Clofilium 5.4
Rocaglamide 5.3
Cucurbitacin I 5.3
Berberine chloride 5.1
Cefozopran 5.1
THP-ADM 5.1
Mitoxantrone 5.1
CITCO 5.0
Mitoxantrone 5.0
CLTC 5.0
(2,4-dichlorophenoxy)acetic acid 5.0
MTIC 5.0
Fast Red TR 4.9
K 10 4.9
Chlorozotocin 4.9
MGBG 4.9
MGBG 4.9
VP-16 4.9
Deoxycoformycin 4.8
Dolasetron 4.8
MEV 4.8
2-decenoic acid 4.7
BLM 4.7
L-PAM 4.7
L-PAM 4.7
Blue Tetrazolium 4.6
Pingyangmycin 4.6
Prednisone 4.6
Aminopterin 4.5
Ifosfamide 4.5
TFF 4.4
RUB 4.4
Epirubicin 4.4
DBB 4.4
EPTC 4.3
VM-26 4.3
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