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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to compare the value of scintigraphy using technetium-99m methoxyisobutylisonitrile (MIBI) with that of scintigraphy using gallium-67 citrate in the assessment of Hodgkin's disease and non-Hodgkin's lymphoma and to relate these results with those of CT scan and MRI. Fifty-eight patients were included either for a follow-up examination or for monitoring of their treatment. Twenty-three residual masses were studied. A whole-body scan was performed, followed by single-photon emission computed tomography (SPET) 20 min after injection of 740 MBq of 99mTc-MIBI and 72 h after injection of 185 MBq of 67Ga citrate. The overall sensitivity of 99mTc-MIBI and 67Ga citrate was 71% and 68%, respectively, and the overall specificity was 76% and 44%, respectively. For residual masses, the sensitivity was 44% with both tracers and the specificity was 80% with 99mTc-MIBI and 53% with 67Ga citrate. The positive predictive values were 85% and 68% and the negative predictive values were 59% and 44%, respectively. The signal-to-background ratio was 1.5 for 99mTc-MIBI and 2 for 67Ga citrate. At present, 99mTc-MIBI cannot replace 67Ga citrate in the assessment of lymphomas.
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PMID:Comparison of technetium-99m methoxyisobutylisonitrile and gallium-67 citrate scanning in the assessment of lymphomas. 775 99

None of the consultants was comfortable with the idea of proceeding with the biopsy of a neck mass in an outpatient clinic setting. All warned about the possible relationship of the mass with important anatomic structures. With regard to needing further information, physicians requested an imaging study of the neck, thoracic cavity, and mediastinum (Dr. Cummings); pelvic examination, breast examination with mammography, chest x-ray, and CBC (Dr. Weymuller); flexible endoscopy, chest x-ray, CBC, and MRI (Dr. Woodson). All three experts advised her to put IVF on hold. After the work-up, they would proceed with a biopsy of the mass and send the tissue to the pathologist in saline. In addition, tissue should be examined for fungus and AFB (Drs. Weymuller and Woodson). Because the patient proceeded with IVF and became pregnant, two experts advised her to abort and proceed with treatment for her Hodgkin's disease (Drs. Cummings and Woodson). The other option was for her to continue her pregnancy and proceed with radiotherapy to her neck, with shielding of the abdomen (Dr. Weymuller).
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PMID:Pregnant woman with a neck mass. 788 50

A case of primary non-Hodgkin lymphoma of the uterine cervix is reported. The ultrasonographic and computed tomographic findings are described as well as the MRI appearance of this peculiar cervical mass. The best tumor delineation was achieved by T2-predominant and contrast-enhanced T1-weighted images. The lesion was treated successfully with external radiotherapy.
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PMID:Primary lymphoma of the uterine cervix. 800 97

A 35-year-old female developed cervical adenopathy and mediastinal tumor in 1988. A lymph node biopsy specimen showed nodular sclerosing Hodgkin's disease. She received combination chemotherapy with cyclophosphamide, vincristine, adriamycin and prednisolone, and radiotherapy for mediastinal tumor. She had a complete remission (CR). In September 1990, she developed swelling of the left hip and felt pain in the left hip and thigh. She also noticed swelling of the left inguinal lymph nodes. MRI T2-weighted images showed enlargement and destruction of the fascia and hyperintense signal of the left iliac and gluteus muscle. A biopsy specimen of the inguinal lymph node showed recurrence of Hodgkin's disease of mixed cellularity. She received salvage therapy with ifosfamide, methotrexate, etoposide and procarbazine, and achieved a second CR. The clinical appearance of the skeletal muscle involvement by lymphoma is uncommon, especially in Hodgkin's disease.
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PMID:[Massive skeletal invasion in Hodgkin's disease observed by MRI]. 813 11

Diagnostic imaging still plays a key role in the follow-up of oncologic patients. In particular, in hemolymphoproliferative disorders, diagnostic imaging is used to differentiate the complications of integrated treatment from possible relapses. Integrated treatments have lengthened the survival of these patients and therefore such long-term complications as secondary--especially solid--tumors are now more frequently observed. We report on two such cases whose onset followed by 6 and 5 1/2 years the end of the initial treatment: the patients had been cured for acute lymphatic leukemia and Hodgkin's lymphoma. In the leukemia patient, CT and MRI demonstrated a large mediastinal mass, which had been an occasional finding at chest film. CT correctly diagnosed the mass and suggested extrapulmonary and extramediastinal localization, since fat cleavages were normal. MRI allowed better characterization of the mass which was isointense to muscle independent of TR. Disease relapse was excluded and surgery allowed the complete ablation of the ganglioneuroma. In the lymphoma patient, a left hypochondrium mass was supposed as an abdominal relapse from Hodgkin's lymphoma. CT allowed the correct diagnosis of gastric adenocarcinoma to be made on the basis of the mass multifocality and marked enhancement, of the infiltration of liver and hepatogastric ligament lymph nodes and finally of peritoneal involvement. Secondary solid tumors are no remote finding in the follow-up of the patients treated for lymphoproliferative disorders. Diagnostic imaging must allow the differential diagnosis especially from relapses and must use the techniques which are most capable of doing so.
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PMID:[Secondary solid neoplasms in young patients treated for lymphoproliferative diseases: computed tomography findings]. 814 67

We report a case of non-Hodgkin lymphoma with CT showing a single, bulky, and round retroperitoneal mass mimicking primary retroperitoneal tumours or metastatic lymph node. On MRI, the tumour was presumed originating from lymph nodes but we could not judge whether the tumour was due to lymphoma or metastasis.
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PMID:Non-Hodgkin lymphoma mimicking primary retroperitoneal tumour on computed tomography. 827 61

This study was aimed at investigating the value of CT and MRI in the staging of sinonasal tumors. The authors report 22 cases of sinonasal tumors: 7 squamous cell carcinomas, 4 adenoid-cystic carcinomas, 1 mucoepidermoid carcinoma, 6 adenocarcinomas, 1 esthesioneuroblastoma, 1 osteosarcoma, 1 small-cell sarcoma and finally 1 non-Hodgkin lymphoma. No significant differences were observed between CT and MR staging: 2 T2 and 15 T4 lesions were diagnosed in the maxillary sinuses and 3 stage-II and 1 stage-III lesions in the naso-ethmoidal region. Tumor spread was similar in 20/22 cases: MRI excluded the involvement of maxillary and sphenoid sinuses in 2 cases. CT was superior in the assessment of bone destruction particularly at the base of the skull, but MRI better demonstrated intracranial spread. MRI detailed the intraorbital muscles and, in the infratemporal fossa, the pterygoid muscles better than CT. High agreement was observed between CT and histology in 5/7 cases and between MRI and histology in 6/7 cases undergoing craniofacial resection. Seventeen of 22 cases had low to intermediate signal intensity on T1-weighted, PD and T2-weighted MR images. Signal was hyperintense in 5 cases: 1 adenocarcinoma with mucinous features, 3 adenoid-cystic carcinomas and 1 esthesioneuroblastoma. In agreement with literature data, this study confirms CT as the examination of choice in staging sinonasal tumors: nonetheless, MRI yields valuable information in the cases with tumor spread to the muscles and soft tissues.
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PMID:[Definition of the T parameter in nasosinusal neoplasms: a CT-MR comparison]. 834 61

Influence of MR-imaging on definition of treatment volume was studied prospectively in 43 patients undergoing radiotherapy for mediastinal malignancy (twelve Morbus Hodgkin, four non-Hodgkin-lymphoma, 26 lung cancer, one nephroblastoma). Conventional treatment planning using a simulator and all available information from axial CT-scanning and posterior-anterior and lateral radiographs was compared to a MRI-assisted procedure. Contours from coronary MR-sections acquired in treatment position were superposed onto the simulator radiograph using a subtrascope (MRI-simulation). MR-imaging using T1-weighted sequences resulted in excellent delineation of tumor masses from mediastinal fat, airways and vascular structures. The high soft tissue contrast allowed an exact and reproducible transfer of tumor contours onto the simulator radiograph. This led to changes in field configuration in 11/43 patients concerning mainly tumor extension infracarinally and in the caudal parts of the lung hili. Superiority of MRI-assisted simulation was noted as usefulness of axial CT-scanning to delineate margins was compromised in these areas by partial volume effects of tangentially represented structures and suboptimal contrasted vascular spaces.
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PMID:Integration of coronal magnetic resonance imaging (MRI) into radiation treatment planning of mediastinal tumors. 839 Nov 72

Current imaging modalities are accurate in establishing the diagnosis and extent of thoracic Hodgkin disease. After treatment, however, it is extremely difficult to differentiate potential residual active neoplastic disease from scar tissue, or identify early recurrence. We evaluated the contribution of MRI in the assessment of the response to treatment of thoracic Hodgkin disease in the assumption that scar formation would be characterized by low signal intensity in all pulse sequences, whereas active tumor should maintain a degree of high signal intensity on T2-weighted images. In 47 occasions (23 patients) both CT and MRI were able to identify correctly active disease, but had low specificity in confirming remission because of residual tissues masses. High signal intensity on T2-weighted MR images often persisted despite remission, probably because of edema, necrosis, granulation or other factors. MRI was somewhat more specific than CT and may be quite valuable to confirm remission in patients with residual masses that no longer appear hyperintense on T2 after treatment.
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PMID:Comparison of CT and MRI in the evaluation of therapeutic response in thoracic Hodgkin disease. 841 60

Following treatment for mediastinal lymphoma, residual masses are defined as a mass greater than 2 cm observed on the CT scan in the absence of other evolutive signs of lymphoma. In this study, we examined 55 patients with residual mediastinal mass after optimal therapy, using gallium scan (37 cases) or magnetic resonance imaging (MRI, 44 cases). The group comprised 41 subjects with Hodgkin's disease and 14 with non Hodgkin's lymphoma, stages I and II (32 cases) and stages III and IV (23 cases); 35 subjects (64%) having bulky mediastinal involvement at diagnosis. A negative gallium scan or fibrotic signal on MRI was correlated with complete remission in 48 cases (87%). In seven of these 48 patients, MRI was not conclusive with a high signal of indeterminate tissue following radiotherapy, but four of the seven had fibrotic tissue on biopsy and none relapsed. Positive gallium scan was observed in six cases. In conclusion, we suggest performing a gallium scan at the end of induction chemotherapy and when it is negative, treatment may be continued without surgical biopsy or salvage therapy. MRI is of value when it shows fibrotic tissue but can be inconclusive.
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PMID:Residual mediastinal mass in malignant lymphoma: value of magnetic resonance imaging and gallium scan. 841 67


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