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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Considerable controversy exists over the routine use of diagnostic staging laparotomy and splenectomy in the workup of patients with Hodgkin's disease. With the development of effective, and perhaps less toxic chemotherapy the need for staging laparotomy has somewhat decreased. In the United States it is still common to recommend surgical staging for early stage patients when the results influence the choice of treatment. Since 20%-30% of clinically staged (CS) IA-IIA and 35% of CS IB-IIB patients with Hodgkin's disease will have occult splenic or upper abdominal nodal involvement not detected by LAG, CT, MRI, or gallium imaging, staging laparotomy allows for selection of patients either to receive limited radiation therapy alone (most PS I-II patients) or chemotherapy with or without radiation (PS III). In Europe, Canada, and South America most patients are clinically staged without a laparotomy. Patients are selected for treatment with radiation therapy alone or for chemotherapy with or without radiation on the basis of clinical prognostic factors. This article details the current arguments for and against the use of staging laparotomy.
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PMID:Controversies in the use of diagnostic staging laparotomy and splenectomy in the management of Hodgkin's disease. 145 79

A 46-year-old man presented with eyelid swelling and choroidal folds in the right eye. These symptoms were rapidly exacerbated, but inflammatory findings were not observed. MRI tomography confirmed the presence of an orbital tumor compressing the eyeball. In 67Ga scintigram, a hot spot was recognized only at the right orbital region. This orbital tumor was removed subtotally. It was diagnosed histologically as non-Hodgkin malignant lymphoma (diffuse medium cell-type) and stained on paraffin sections, using monoclonal antibodies immunohistochemically. Anti-LCA, anti-MT-1, anti-UCHL-1 antibodies were positive, and anti-MB-1 antibody was negative. The clinical stage was IE in the Ann-Arbor classification. He was treated by radiation and chemotherapy, but died because of opportunistic infection after 6 months. This is, so far as we know, the first case in Japan diagnosed as primary orbital T-cell type malignant lymphoma immunohistochemically.
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PMID:[A case of primary orbital T-cell lymphoma]. 147 81

Seven patients with primary non-Hodgkin lymphoma of the skeleton were examined with MRI. The results were compared to "small cell" primary malignant bone tumors. The latter showed marked hyperintensity on SE T2-weighted images; in contrast, the lymphomas appeared as inhomogeneous lesions of low signal intensity on T2-weighted images. Histologic examination with silver stains of specimens of these lesions revealed a high content of fibrous tissue, which could explain the signal behavior on MR. All seven lymphomas were located in the epiphysis or metaphysis of the appendicular skeleton; intraarticular tumor growth was demonstrated in five cases.
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PMID:MRI in the diagnosis of primary lymphoma of bone: correlation with histopathology. 154 21

Radiotherapy treatment planning needs optimum definition of target volume in its relative position to normal tissue. The aim of our study was to achieve individual field definition in subdiaphragmatic radiotherapy by visualization of the target volume using fast, breath-held MRI and MR angiography. A modified rapid acquisition SE technique (SE 150/10) was used to obtain a coronal image within a 14 s breath-holding period, displaying kidneys, spleen, and lumbar spine on one slice. Coronal MR angiography acquisition in breath-hold technique was performed using a sequential FLASH-2D sequence (FLASH-2D 30/10/30 degrees). For reconstruction of the MR angiogram in coronal view, we used a maximum intensity projection algorithm. A computer program superimposed the MR angiogram onto the MR image. Correct magnification of the superposition image allowed direct projection onto the simulation film. Problems of distortion and different projection techniques were taken into account and quantified by phantom measurements. The localization error measured in a reference plane was less than 5 mm within a radius of 140 mm. Fourteen cases of Hodgkin disease and non-Hodgkin lymphomas were treated employing the novel technique. By superposition of the MR image and the MR angiogram, demarcation of vascular architecture from parenchymatous organs was achieved. Projection of the MR superposition onto the simulation film yielded accurate and convenient field definition using noninvasive imaging techniques.
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PMID:MRI and MRA in treatment planning of subdiaphragmatic radiation therapy. 172 89

Three types of lymphoma of the central nervous system are known: primary non-Hodgkin's malignant lymphoma (NHML), secondary NHML and neurological lesions of Hodgkin's disease. NHML's are rare tumours, often associated with immunodeficiency and presenting predominantly as neuropsychological disorders. In this study 8 patients were explored by CT and MRI, with pathological confirmation. None of our patients had AIDS. The most typical neuroradiological image of this type of tumour is that of a large and intensely contrast-enhanced tumoral mass which is often multifocal and periventricular with infiltration of the subarachnoidal spaces and leptomeninges. Mass effect and perifocal oedema are less pronounced than expected with tumours of that size. NHML's may totally regress under corticosteroid therapy. This tumour of obscure aetiology must be recognized as it is now increasingly frequent.
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PMID:Primary and secondary lymphomas of the brain: an MRI study. 191 83

Radiation angiopathy was developed by the process of accelerated atherosclerosis at the site of irradiation. The case of a 44-year-old man with right hemiparesis showing a high signal intensity in the left semioval center on MRI and a defect in the left temporo-parietal area with subsequent filling-in with I-123 IMP brain SPECT is reported. Digital subtraction angiography showed typical radiation angiopathy with ulceration in the left common carotid artery. Twenty-four years previously, he underwent curative irradiation of a neck mass that revealed Hodgkin's disease by biopsy. The emboli formed at the site of radiation-induced angiopathy and caused cerebral infarction. The perfusion abnormality in the territory of the embolic artery was detected by I-123 IMP SPECT. Long-term survivors of neck irradiation are at high risk for the development of carotid arterial disease and should be watched carefully.
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PMID:Embolic stroke following carotid radiation angiopathy demonstrated with I-123 IMP brain SPECT. 193 11

Seventy-four consecutive previously untreated patients with Hodgkin's disease (HD) and non-Hodgkin lymphomas (NHL) were evaluated with chest, abdominal and pelvic magnetic resonance (MRI) for initial staging. All patients underwent routine radiological staging procedures which included chest radiographs and lymphography (LAG). These studies were followed in most of cases by laparoscopy, during which biopsies of the liver and the spleen were taken, and bone marrow aspiration and histology. A correlation of the results of MRI with both other imaging studies and histopathologic diagnoses was performed, and discordant cases were assessed to determine the impact on clinical staging. Additional evidence of disease involvement was provided mainly in the chest, where MRI demonstrated the presence of unsuspected disease in 21% of involved patients (9 of 42). Retroperitoneal lymph nodes were correctly assessed in 97% of cases if MRI was compared with LAG. Extranodal abdominal disease was identified both in the spleen (14%) and in the liver (1%). Bone marrow abnormalities were detected in 19% of patients (14 of 74). MRI findings influenced the staging of HD and NHL patients in 11 of 74 cases (15%).
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PMID:Magnetic resonance imaging in the initial staging of Hodgkin's disease and non-Hodgkin lymphoma. 203 5

4.5 months after successful kidney transplantation a Non-Hodgkin-lymphoma with polymorph centroblastic appearance of the tonsillar gland developed in a 21 years old male patient during immunosuppressive therapy with cyclosporine A and prednisone parallel to infection with Epstein Barr virus. Focal epileptic seizures occurred and were due to cerebral posttransplantation lymphomas as proven by brain biopsy. Reduction of immunosuppressive therapy led to complete remission as shown by CCT and MRI.
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PMID:[Regression of cerebral post-transplantation lymphoma under cyclosporin A reduction]. 228 May 83

Lymphocyte predominance subtype of M. Hodgkin with disease of the upper cervical and/or preauricular lymph nodes more often shows simultaneous involvement of nasopharynx. Epipharyngoscopy alone is not always diagnostic. Staging has to be completed by additional computed tomography and/or MRI of the nasopharynx. In case of involvement enlargement of target volume is mandatory.
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PMID:[Nasopharyngeal involvement in Hodgkin's disease--its diagnosis by CT and MRT. A case report]. 233 May 42

Fifteen consecutive patients with refractory or relapsed Hodgkin's disease (HD) referred for autologous bone marrow transplantation (ABMT) underwent quantitative magnetic resonance (MR) studies of the lumbar vertebral bone marrow. Markedly elevated lumbar vertebral marrow T1 values suggestive of bone marrow involvement with HD were seen in four patients, two of whom had no evidence of HD on bilateral iliac crest bone marrow biopsy. Serial studies showed normalisation of T1 values in the post-transplant period. T1 relaxation rate correlated positively with time to engraftment following ABMT and a significant correlation (r = 0.73, 0.02 greater than P greater than 0.01) between T2 relaxation rate and granulocyte and macrophage colony forming units (CFU-GM) of processed bone marrow was seen. This preliminary study illustrates the potential role of quantitative MRI both in the pre-transplant assessment of patients considered for ABMT and in the post-transplant evaluation of tumour response when marrow involvement with HD is present.
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PMID:Quantitative magnetic resonance imaging in autologous bone marrow transplantation for Hodgkin's disease. 260 6


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