Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The occurrence of lymphoid malignancy tissue, most often Hodgkin or non-Hodgkin lymphoma, after several years of the diagnosis of sarcoidosis has been named sarcoidosis-lymphoma syndrome. The pathogenesis of this syndrome is probably connected with dysregulation of T lymphocytes. A woman with acromegaly with non-Hodgkin lymphoma diagnosed six years after sarcoidosis is presented in this paper. The CVP chemotherapy helped to establish 9-years, lasting remission still.
Pol Arch Med Wewn 1995 Dec
PMID:[Sarcoidosis-lymphoma syndrome in a woman with acromegaly]. 861 18

Transthyretin and albumin in lumbar cerebrospinal fluid (CSF) and in serum were repeatedly assessed in 40 patients with acute leukemias or high grade non-Hodgkin's lymphomas. The patients were divided into 3 groups. Group I-5 individuals with clinical manifestations of leukemic or lymphomatous meningosis; Group II-33 cases with no clinical data of central nervous system involvement by neoplasm (leukemia/lymphoma); Group III-2 patients in whom extramedullary solid leukemic or lymphomatous infiltrations were diagnosed. It was revealed that blood-brain-barrier dysfunction due to neoplastic infiltration of leptomeninges went with an increase of albumin blood-CSF barrier dependent- and with decrease of blood-CSF barrier-independent transthyretin concentrations. In patients with extramedullary tumors an evident increase of albumin and total-CSF transthyretin and no blood-CSF barrier-independent transthyretin concentrations below the tumor location were observed. It can betray a complete block of the vertebral canal subarachnoid space below the neoplastic compression of the spinal cord. Cytostatics application, either general or intrathecal, did not influence the CSF albumin and transthyretin levels.
Acta Haematol Pol 1996
PMID:[Transthyretin and albumin in cerebrospinal fluid in patients with acute leukemias or lymphomas of high grade malignancy]. 862 47

We describe the initial presentation of Hodgkin's disease, which 40 years ago was generally not diagnosed until its advanced stages. The diagnosis is now being made earlier. The initial symptoms of Hodgkin's disease are described; this may facilitate earlier diagnosis.
Pediatr Pol 1995 Mar
PMID:[Once again about the early diagnosis of Hodgkin's disease]. 865 86

Clinical studies of antiemetic treatment with Zofran in children suffering from neoplastic diseases are presented. The studies were carried out in 33 children aged 3 months to 17 years treated in 1993. The majority of the patients were treated for ALL (20), Hodgkins disease (3), nephroblastoma (3), non-Hodgkin lymphoma (2), solid tumors (5). Two-hundred thirty-eight cycles of chemotherapy with cystostatics having varied emetic effects were carried out in these children. Zofran was given in one dose, one hour before chemotherapy in a dose of 4 or 8 mg. The intensity of vomiting was assessed according to the WHO 5-grade scale. O to 1 grade of vomiting was observed in 84.4%, 2nd grade in 15.2%. There were no cases of 3rd or 4th grade vomiting. No side-effects of the medication were observed in the studied group. It was found that Zofran is an effective and well-tolerated antiemetic medication in children on chemotherapy.
Pediatr Pol 1995 Nov
PMID:[Estimation of effectiveness of antiemetic treatment with Zofran given in one dose to children with neoplasms]. 867 58

The efficacy of 3 schemes of passive and active prevention of HBV infection was evaluated in 47 children with haematologic proliferative diseases. Twenty-six children suffering from leukemia (group I) received passive immunisation (hepatitis B immunoglobulin) in six week intervals during intensive chemotherapy and were vaccinated on maintenance therapy. Thirteen children with Hodgkin or B-non-Hodgkin lymphoma (group II) received active immunisation from the beginning of intensive chemotherapy with two doses of immunoglobulin. Eight children who had completed their therapy (group III) were vaccinated only. Among children who completed vaccinations, 5/8 in group I, 4/7 in group II and 5/5 in group III produced protective anti-HBs levels. Passive/active prophylaxis was successful in most patients suffering from neoplastic diseases and reduced the endemy of HBV infection in our department from 43.3% to 2.56% infected subjects. Among 7 patients vaccinated from the beginning of treatment (group II), 4 of them produced protective levels of anti,-HBs, despite intensive chemotherapy.
Pediatr Pol 1995 May
PMID:[Efficacy of passive and active immunization against HBV infection in children with neoplastic diseases]. 869 93

A characteristic feature of follicular non-Hodgkin's lymphomas (FL) is a chromosome translocation t(14;18)(q32;q21). In American patients the t(14;18) can be found in the large majority (approximately 70%) of FL and in a significant (10-40%) percentage of diffuse large cell lymphomas (DLCL). However there are reports suggesting that geographic or racial factors may regulate genesis of lymphomas with BCL2 abnormalities. Herein we present results of molecular analysis for t(14;18) in lymphomas in Poland. Analyses were performed on 37 cases of FL, 55 cases of diffuse lymphomas (DL) and 39 cases of Hodgkin's disease (HD). By Southern and polymerase chain reaction BCL2 translocation within major breakpoint region was found only in 3 of 37 FL, 1 of 55 DL and 2 of 39 HD. These results are the lowest reported ratio. We hypothesize that environmental factors may regulate BCL2 associated lymphomagenesis.
Pol J Pathol 1995
PMID:Environmental factors may regulate BCL2 associated lymphomagenesis: a very low incidence of BCL2-MBR translocation in Poland. 871 88

Polyneuropathy in neoplastic process practically may occur in every stage, before clinical signs, together with clinical signs and in the last period. In some percent of patients polyneuropathy may outstrip manifestation of neoplastic process even for many years. We present a 61-year-old patient in whom signs of polyneuropathy appeared before the signs of essential disease - Hodgkin's disease. Our case confirms the necessity of very careful and precise diagnostics of polyneuropathy with unclear aetiology.
Neurol Neurochir Pol
PMID:[Polyneuropathy in the course of Hodgkin's disease: case report]. 875 57

We recorded intracellular responses from cat retinal ganglion cells to sinusoidal flickering lights, and compared the response dynamics with a theoretical model based on coupled nonlinear oscillators. Flicker responses for several different spot sizes were separated in a "smooth" generator (G) potential and corresponding spike trains. We have previously shown that the G-potential reveals complex, stimulus-dependent, oscillatory behavior in response to sinusoidally flickering lights. Such behavior could be simulated by a modified van der Pol oscillator. In this paper, we extend the model to account for spike generation as well, by including extended Hodgkin-Huxley equations describing local membrane properties. We quantified spike responses by several parameters describing the mean and standard deviation of spike burst duration, timing (phase shift) of bursts, and the number of spikes in a burst. The dependence of these response parameters on stimulus frequency and spot size could be reproduced in great detail by coupling the van der Pol oscillator and Hodgkin-Huxley equations. The model mimics many experimentally observed response patterns, including non-phase-locked irregular oscillations. Our findings suggest that the information in the ganglion cell spike train reflects both intraretinal processing, simulated by the van der Pol oscillator, and local membrane properties described by Hodgkin-Huxley equations. The interplay between these complex processes can be simulated by changing the coupling coefficients between the two oscillators. Our simulations therefore show that irregularities in spike trains, which normally are considered to be noise, may be interpreted as complex oscillations that might carry information.
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PMID:On the complex dynamics of intracellular ganglion cell light responses in the cat retina. 893 81

20 patients in early stages (I-IIB) Hodgkin's disease were treated with smaller than commonly used doses of cytostatics and radiation. Men were given EBVD-CVPP-EBVD (epirubicin, bleomycin, vinblastine, DTIC, cyclophosphamide, vinblastine, procarbazine, prednisone) and women: CVPP-EBVD-CVPP. Radiotherapy was limited to involved and adjacent fields. In all patients complete remission was achieved lasting now 9 to 107 months (mean 55 months). Two patients relapsed. No undesirable early side effects were observed. Further observations will show if such therapeutic option in non-advanced Hodgkin's disease is sufficient.
Pol Arch Med Wewn 1996 Nov
PMID:[Preliminary results of conservative combination radiotherapy and chemotherapy in early stages of Hodgkin's disease]. 909 57

The aim of the present paper is to describe the different attempts at modeling cardiac electrophysiological mechanisms, mainly at the membrane and cellular level, from action potential genesis to its propagation in myocardium. The Hodgkin and Huxley model describing the nervous action potential's theoretical reconstruction is first recalled, for it represents the basic model for a large part of cardiac action potential models. These models (Beeler and Reuter, Van Capelle and Durrer, Luo and Rudy) are then successively studied as their main applications by diverse authors. Varied approaches, like the Fitzhugh-Nagumo model (derived from the Bonhoeffer-Van der Pol model of oscillatory systems) or cellular automata models applied to the study of ventricular activation wave propagation and diseases associated with its perturbation, are then presented and discussed. Other, different approaches, such as general studies of excitable media, are evoked. This paper concludes with a critical evaluation of these different methods of electrophysiological cardiac modeling and of the main domains in which they led to significant results and in which they appear able to generate future perspectives.
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PMID:Modeling of cardiac electrophysiological mechanisms: from action potential genesis to its propagation in myocardium. 910 84


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