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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ability of neutrophil granulocytes to mobilization in sterile inflammatory focus was studied in patients with Hodgkin's disease during treatment. Plastic chambers filled with patient's serum were used for this purpose. The migration ability of granulocytes in the group of patients was reduced already before beginning of treatment. It decreased even more 3 days after beginning of cytostatic treatment but on the 7th day the number of cells passing into the inflammatory exudate increased to values observed in healthy subjects. The observed changes were not correlated with fluctuations in the granulocyte count in the peripheral blood observed on the same days. It is suggested that the evaluation of migration ability of granulocytes to the inflammatory focus may provide better information about the defensive mechanisms of the organism than determination of the count of these cells in the peripheral blood.
Acta Haematol Pol 1976
PMID:[Tissue migration of neutrophil granulocytes in the course of antiproliferative treatment in Hodgkin's disease]. 93 62

In 83 patients (40 females and 43 males) aged from 17 to 69 years belonging to 190 cases of Hodgkin's disease treated as inpatients in the Institute of Haematology in Warsaw in the years 1966-1974 radiological investigations of the skeletal system were done. In 17 cases (20.4%) bone changes were demonstrated appearing as rarefaction (9 cases), sclerosis (6 cases) or mixed (2 cases) changes. The changes were located most frequently in the spine, less frequently in the epiphyses of long bones and flat bones. All 17 cases with bone changes were qualified as IV clinical stage of disease progression. Radiological osseous changes were not pathognomonic and it was difficult to draw conclusions as to the mode of spread. Bone pains were present in 8 patients, including 7 with spinal changes. In some cases treated postmortem specific infiltrations were found in bone marrow.
Acta Haematol Pol 1976
PMID:[Osseous changes in Hodgkin's disease and cellular bone marrow infiltrations]. 93 65

The NBT reduction test and determination of alkaline phosphatase activity in the peripheral blood granulocytes (FAG) were done in 94 subjects including 30 blood donors donating blood for the first time and 64 cases of various haematological syndromes. Raised proportion of formazan granulocytes was found in patients with pancytopenia, acute myeloid leukaemia, chronic myeloid leukaemia during blastic exacerbation, Hodgkin's disease during exacerbation and lymphosarcoma. These results correlated with increased FAG activity. Lower proportions of formazan granulocytes capable of spontaneous reduction of NBT were found in patients with chronic myeloid leukaemia, in immunohaemolytic anaemias and in plasmocytoma. Of all the above syndromes only in chronic myeloid leukaemia impaired ability of formazan cell formation parallelled decreased FAG activity. In the remaining syndromes FAG activity in the granulocytes was normal or raised. In the remissions of Hodgkin's disease a fall was observed in the proportion of formazan granulocytes to values of FAG. In chronic myeloid leukaemia the proportion of formazan cells showed considerable fluctuations and no correlation was observed between the proportion of formazan cells and FAG activity.
Acta Haematol Pol
PMID:[Spontaneous nitroblue terazolium reduction test (NBT) by peripheral blood granulocytes in healthy subjects and in some hematologic syndromes]. 105 43

HL-A antigens were determined in 46 patients with Hodgkin's disease and a statistical analysis was carried out by the chi square test to compare the incidence of these antigens in patients with that in healthy people. Statistically significant differences were found in the first place in the HL-A5 antigen (chi square = = 32.2) (p less than 0.005). This antigen was much more frequent in patients (43%) than in the healthy population (15%). A slightly lower frequency of antigen W5 was found in the group of patients (healthy controls -- 13.5%, patients -- 4.5%, chi square = 7.08, p less than 0.05).
Acta Haematol Pol
PMID:[HL-A antigens in patients with Hodgkin's disease]. 119 75

A conversational program is described which is being used for exploratory modelling of digestive tract electrical activity. The structure of the mathematical model is based on the Hodgkin-Huxley equations for nerve axons and the Noble equations for Purkinje fibres of the heart. The parameters of the models are changed conversationally to investigate the effects of frequency, amplitude and waveshape. In this way it is intended to extend the models to include nervous control. The program is also being used to correlate the behaviour of H-H type equations with the simpler dynamics of Van der Pol's equation which is the basis of an oscillator-array model for the stomach and small intestines.
 ...
PMID:A conversational program for analytical modelling of action potentials in nerve and muscle. 120 54

Patients with advanced lymphogranulomatosis were divided into two subgroups. One, including 9 patients was treated in the hospital, and the second, including 21 patients, was treated at out-patient department. Results of the treatment and its adverse reactions were not significantly different in patients treated on out-patient basis and in hospital. However, unfavourable effect of therapy on patient's psychological status (anxiety) was less expressed in out-patient conditions. Such a way of treatment enables also considerable savings related to the repeated hospitalizations.
Pol Tyg Lek
PMID:[Evaluation of ambulatory treatment of advanced forms of Hodgkin's disease with special reference to psychological, social and economic aspects]. 127 42

A rare case of Hodgkin's lymphoma metastasis to the spinal cord is reported. The first signs of the metastasis appeared in the 6th year of cytostatic treatment. Diagnostic difficulties hampered causative treatment.
Neurol Neurochir Pol
PMID:[A rare case of metastasis of Hodgkin's disease to the spinal cord]. 128 6

Clinical examination and conduction velocity measurements in peripheral nerves have been done on 56 patients with non-Hodgkin's lymphomas of high malignancy (NHL). It is suggested that: the evaluation of the influence of chemotherapy on peripheral nervous system (PNS) is possible by means of systematic neurological and electroneurographic studies; electroneurographic assessment is most important in the diagnosis of early subclinical stages of peripheral neuropathy; toxic influence of CBVPM/AVBP protocol on PNS is greater than CHOP schedule; impairment of PNS due to chemotherapy is reversible in patients during complete remission (CR).
Acta Haematol Pol 1992
PMID:Impairment of peripheral nervous system in patients with non-Hodgkin's lymphomas treated with CBVPM/AVBP and CHOP schedules. 128 82

In twenty four patients diagnosed with Hodgkin's disease we have determined several antiproteases. Our findings have shown the decrease of concentration of alpha-2-macroglobulin and increase of alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. The observed changes were statistically significant p < 0.001. We did not find any correlation between the concentration of inhibitors and the clinical stage of carcinoma and histopathological data. The determination of the level of antiproteases in patients with cancer disease may be assumed to reflect partly at least the capability of anticancer mechanism in the host.
Mater Med Pol
PMID:Serum concentration of alpha-2-macroglobulin, alpha-1-antitrypsin and alpha-1-antichymotrypsin [correction of alpha-2-antichymotrypsin] in patients with Hodgkin's disease. 128 80

The neurological and electroneurographic assessment was carried out in 56 patients with high-grade non-Hodgkin lymphomas. In 37 patients the neuropathological examination was also done. Polyneuropathy was the most frequent sign of nervous system involvement, observed in 40% of patients before chemotherapy and markedly enhanced by cytostatics. The signs of the central nervous system involvement were usually caused by lymphomatous infiltrations within leptomeninges, especially in lymphoblastic and immunoblastic lymphomas. The authors stress that cerebro-spinal fluid should be investigated several times for avoiding of false negative results. Signs of lymphomatous infiltrations disappeared after treatment, while signs of polyneuropathy due to chemotherapy increased during cytostatic treatment.
Neurol Neurochir Pol
PMID:[Neurologic complications in high-grade non-Hodgkin's lymphomas. Clinico-neuropathological correlations]. 133 70


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