Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Presence of alfa-fetoprotein was found in serum of patient in whom primary hepatoma was suspected. The post-mortem microscopical examination did not confirm the clinical diagnosis ut showed changes typical for Hodgkin's disease.
Acta Haematol Pol
PMID:[Alpha fetoproteins in serum of a patients with Hodgkin's disease]. 7 Jan 50

The authors gave Lycurim to 30 patients with malignant lymphoma (LLC--12 cases, Hodgkin's disease - 15 cases, reticulosarcoma - 2 cases and lymphosarcoma - 1 case). The patients were divided into three groups. Group I received only Lycurim, group II - Lycurim and prednisone, group III - Lycurim and Solcoseryl. Significant improvement was observed in 22 patients, with complete remission in 5 cases and partial in 17 cases. Leucopenia and thrombocytopenia precluding treatment were never observed in cases treated simultaneously with prednisone or Solcoseryl. The authors believe that the proportion of remissions may be increased combining Lycurim with vincristine, procarbazine and glycocorticosteroids (LOP or LOPP).
Acta Haematol Pol
PMID:[Preliminary observations on the results of treating malignant lymphoma with Lycurim]. 20 51

A patient with Hodgkin's disease is reported in whom 5 years after establishing of diagnosis acute myeloid leukaemia developed during multistage treatment. The patient died. The authors discuss the problem of leukaemia-inducing influence of intensive radiotherapy and chemotherapy.
Acta Haematol Pol
PMID:[Acute myeloid leukemia during Hodgkin's disease]. 28 73

The proportions of T and B lymphocytes were determined in lymph nodes removed from 30 patients with Hodgkin's disease and in 18 control lymph nodes. In all lymph nodes obtained from patients with Hodgkin's disease histological examination demonstrated presence of typical granulation tissue of type Ns, Mc, Ld (changes of Lp type were not found). In the control lymph nodes no neoplastic changes or inflammatory reactions were observed. For identification of T cells the rosette test E was used and for identification of B cells --- the EAC rosette test and tests for presence of Ig on their surface by the immunofluorescent method (L Ig+). It was found that the proportions of T and B cells in the lymph nodes obtained from patients with Hodgkin's disease were not different from those in control lymph nodes. The percent values of T and B cells were similar in all three histological types of changes in Hodgkin's disease. Early radiotherapy was not connected with a change in T and B cell proportions in the irradiated lymph nodes.
Acta Haematol Pol
PMID:[Proportion of B- and T-lymphocytes in lymph nodes removed from patients with Hodgkin's disease]. 30 24

Investigations were carried out on the effects of splenectomy on the immune state of patients with Hodgkin's disease during remission. In similarly treated non-splenectomized and splenectomized patients the proportions and absolute count of T and B lymphocytes were determined in peripheral blood. For identification of T cells the rosette test E was applied. B cells were identified by the method of EAC rosette test and by determination of immunoglobulins on their surface. For functional assessment of lymphocytes their blastic transformation was determined after stimulation with PHA, Con A and PWM. It was found that the proportions and counts of T and B lymphocytes in preripheral blood were not different in both groups. The values of blastic index in the cultures of lymphocytes stimulated with mitogens were higher, on the other hand, in non-splenectomized patients in relation to splenectomized ones. In the light of these investigations it is suggested that splenectomy in patients with Hodgkin's disease caused functional disturbances of lymphocytes. Further investigations are indispensable for establishing whether lymphocyte function impairment manifests itself with clinically detectable disorders of immune processes.
Acta Haematol Pol
PMID:[Proportions and absolute count of T- and B-lymphocytes in peripheral blood and their blastic transformation induced by mitogens in splenectomized and non-splenectomized patients with Hodgkin's disease]. 30 25

14 untreated patients with Hodgkin's disease were tested for lymphocte reactivity in vitro to optimal and suboptimal doses of PHA. A PHA dose-dependent defect in lymphocyte stimulation was demonstrated in patients when compared with a group of normal individuals. No correlation between the in vitro defect and decreased absolute number of E-rosette-forming cells (T-lymphocytes) in peripheral blood was found.
Acta Haematol Pol
PMID:PHA dose dependent defect in lymphocyte stimulation and E-rosette-forming cells in untreated Hodgkin's disease. 32 29

In 36 patients with stage III and IV of Hodgkin's disease granulocyte adherence was investigated. The determinations were carried out in minicolumns filled with nylon fibres. In 13 patients the determinations were repeated 2, 4, 6, 12 and 24 hours after administration of vinblastine and cyclophosphamide. In all patients granulocyte adherence was reduced, by 54.1 +/- 3.5% on the average. The values of adherence in the control group were of the order of 83.7 +/- +/- 4.7%. Administration of antiproliferative drugs reduced further the adherence. The lowest value of it was observed 6 hours after vinblastine and cyclophosphamide administration. After that time the adherence increased gradually reaching the initial level 24 hours after administration of antiproliferative agents. These results suggest that reduced adherence of granulocytes may be an additional cause, besides abnormal immunological reactions, of the impairment of the resistance mechanisms of the organism in advanced stages of Hodgkin's disease.
Acta Haematol Pol
PMID:[Granulocyte adherence in advanced Hodgkin's disease and its dependence on antiproliferative drugs used]. 37 64

The studies were performed to estimate the sensitivity of chronic lymphocytic leukaemia (CLL) lymphocytes (32 patients), non-Hodgkin lymphoma (NCL) lymphocytes (3 patients) and normal human (NH) lymphocytes (20 persons) to antimitotic concentration of colchicine in the conditions of the in vitro Thomson's test. Significant differences were observed in this sensitivity test: for CLL lymphocytes the mean values was 79%, for N-HL-lymphocytes 37%, for NH-lymphocytes--12%. These data show the possibility of practical use of Thomson's test in differential diagnosis of increased lymphocytosis. A quantitative heterogeneity of colchicine sensitive (pathological) and non-sensitive ("normal") CLL lymphocyte populations was observed among different CLL patients. There was no correlation between the proportion of the above populations and the patient's age, duration of illness and the magnitude of total lymphocytosis.
Acta Haematol Pol 1979 Oct
PMID:[Thomson's colchicine test in differential diagnosis of lymphocytic leukemia and non-Hodgkin lymphoma]. 53 54

Combined three-drug (case I) and four-drug (case II) therapy and radiation was applied for control of relapse in two children with Hodgkin's disease. Remission was maintained with chemotherapy type MVPP (9 courses of treatment) and vinblastin administered between these courses. The survival is 106 months in one case and 90 months in another and the time from beginning of treatment of recurrence is 78 and 81 months respectively. The observation after the end of treatment is 31 and 43 months respectively.
Acta Haematol Pol
PMID:[Long-standing remission following relapse in Hodgkin's disease in 2 children]. 66 28

In 82 patients with non-Hodgkin lymphoma (NHC) the DNA synthesis by mononuclear cells from the peripheral blood was assessed by means of the index of mitoses (IM) or by pulse labelling of cells with 3H-TdR. In chronic lymphatic leukaemia (47 cases), hairy-cell leukemia (1 case), plasma-cell leukaemia (1 case) no synthesis of DNA was found in mononuclear cells. On the other hand, it was raised in most cases of lymphoplasmocytoma, centrocytoma, centroblasto-centrocytoma, centroblastoma and in lymphoblastic leukaemia or lymphoma.
Acta Haematol Pol
PMID:[Mononuclear peripheral blood cells in patients with non-Hodgkin's lymphoma synthesizing DNA in vitro]. 71 94


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