Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cultures of peripheral blood mononuclear cells (PBM) from 33 patients with Hodgkin's disease, were stimulated in vitro with pokeweed mitogen (PWM) or influenza antigen. Impaired production of immunoglobulin (Ig) of one or more of the three main classes (IgG, IgM and IgA) in PWM stimulated cultures was found in 22 patients and in 11 patients no Ig of any class was produced. Antibody to influenza virus was detected in PWM stimulated PBM cultures in 13 of 14 normal individuals, but in only four of 25 patients with treated Hodgkin's disease though IgG was produced in 16 of 25. Influenza antigen induced anti-influenza antibody production in 10 of 12 cultures from normal individuals but in only two of 22 from patients. The results confirm our earlier report of defective antibody production in vitro by PBM from patients with Hodgkin's disease and indicate that polyclonally activated production of immunoglobulins of several classes is defective, though in vivo humoral immunity is normal.
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PMID:Defective in vitro antibody production in response to pokeweed mitogen and influenza antigen in patients with Hodgkin's disease. 400 4

In 27 cases of malignant lymphogranulomatosis investigations were made on the intracellular presence of severe chains of immunoglobulins (IgM, IgG, IgA) in plasma cells and prestages of plasma cells or in atypical cells (Sternberg-Reed, mirror picture, and Hodgkin cells) by using the immunoperoxidase method. In 7 cases an intensive intracellular colouring of IgG could be observed, with immature prestages of plasma cells being present simultaneously (plasmoblasts, immunoblasts). In 16 cases IgG was slightly marked only, no plasma cells being present. With regard to the first group the development of atypical cells in these cases may be supposed to be connected with the presence of precursors of plasma cells.
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PMID:[Intracellular immunoglobulins in lymphogranulomatosis]. 616 29

An immunoperoxidase study of 20 cases of Hodgkin's disease demonstrated universal staining of Reed Sternberg cells and their mononuclear variants for both kappa and lambda light chains and, in all but one case, for IgG. Staining for IgA and albumin was variable and for IgD and IgM uniformly negative. A double staining procedure using two different chromogens produced the paradoxical finding of both light chain types within the same cell, but these could only be demonstrated sequentially and not simultaneously, suggesting a blocking phenomenon. The above findings coupled with the demonstration of muramidase and/or alpha-1-antitrypsin in Reed-Sternberg cells and their mononuclear variants in all but two cases studied favor a histiocytic origin for these cells. This characteristic profile of results is also very helpful in distinguishing Hodgkin's disease from other neoplasms which mimic Hodgkin's disease because of the presence of Reed-Sternberg-like cells.
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PMID:Immunohistochemistry of Hodgkin's disease. A study of 20 cases. 619 77

A 50-year-old Danish male presenting with swelling in fossa supraclavicularis and slight swelling of axillary and inguinal lymphnodes was diagnosed histologically as having malignant, non-Hodgkin, blast lymphoma. The EBV association was established by demonstration of EBV-DNA-positive tumor cells and the presence of high titers of antibodies of the IgG class to VCA, EA (D) and EBNA. The unique finding in this case was the high titers of IgA antibodies to VCA and to EA (D). This latter serological picture is characteristic of nasopharyngeal carcinoma (NPC) but has not previously been observed in Burkitt's lymphoma.
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PMID:A Danish adult case of EBV-positive Burkitt's lymphoma. 629 57

A breast tumour from a 65-year old woman was found to be a primary non-Hodgkin lymphoma, a very rare primary malignancy in this location. The lymphoma was of a diffuse histiocytic type according to the classification of Rappaport, or polymorphic immunocytoma according to the Kiel classification. Immunohistochemistry, not previously reported for breast lymphomas, revealed the production of IgA. In the serum this appeared as an IgA M-component which was greatly reduced after tumour removal. Immunological properties of primary breast lymphomas are reviewed, we suggest further extended studies with the immunohistochemical use of marker substances for the evaluation of prognosis.
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PMID:Immunoglobulin-A producing probably primary lymphoma of the breast. 640 91

This paper describes a fluorescent pattern of human antibodies circulating in the serum of a 57 year old patient with lymphogranulomatosis. Following incubation with different FITC-labeled anti-human IgG sera including F(ab)2-fragments and with antibodies to human IgA, IgM, IgD, IgE as well as guinea pig serum and FITC-labeled anti-guinea pig serum (for proof the complement binding), it can be assumed that this is a non complement binding IgG antibody directed first of all against the rat gastric mucosal lamina propria (in the cardia and corpus and weaker in the pylorus region). The titre was 1:640. 1:80 diluted serum did not react with duodenum, jejunum, colon, tongue, oesophagus, parotid gland, trachea, lung, heart, diaphragm, liver, spleen, or kidneys. Among others, the species specificity and the antigen binding sides remain to establish.
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PMID:Immunohistochemical demonstration of human circulating antibodies against lamina propria of gastric mucosa. 641 Jun 63

We report the results of immunologic studies in a family in which the father (III-5) and his two daughters (IV-7 and IV-8) had the hyper-IgM syndrome (IHIS). Repeated immunoglobulin levels done on III-5 showed a typical IHIS pattern: low IgG, traces of IgA, and high IgM. IV-7, who also had stage IIA Hodgkin's disease, had a similar pattern except after irradiation therapy to sites of disease, when IgM dropped to normal range while IgG and IgA remained low. IV-8, on the other hand, had normal IgG and IgA and moderately elevated IgM until age 18 months, when she gradually developed the IHIS pattern. All three patients had normal numbers of B cells (sIg) and of T cells, although IV-7 had increased suppression. Finally, all three patients shared the A3,B7 haplotype and none was blood type O. IHIS is not necessarily X linked, is not associated with blood type O, and appears to be heterogeneous even within the same family. Inheritance in this family is apparently autosomal dominant and the father may represent a new mutation.
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PMID:Immunologic studies of three family members with the immunodeficiency with hyper-IgM syndrome. 660 45

Sera from 28 untreated patients with Hodgkin's disease and from 120 healthy controls were investigated for the presence of circulating immune complexes using a modified 3% polyethylene glycol precipitation method with subsequent quantification of the precipitated protein. Elevated levels of precipitable protein were found in 79% (p less than 0.005) of Hodgkin's disease sera. The degree of elevation was associated with disease activity including the presence of B-symptoms. Constant and pronounced increase of precipitable protein was found in six patients with stage-III B nodular sclerosis subtype, thus exceeding the average amount of precipitable protein in healthy controls by a factor of 3-4. The erythrocyte sedimentation rate in 20 patients correlated with the amount of precipitable protein (r = 0.79). Additionally, partial component analysis of the precipitates was carried out by laser nephelometry. Immunoglobulins and complement components were identified as being major components of the precipitated material in sera both from patients and healthy controls, thus confirming the probability of the immune complex nature of the precipitates. Significant differences between patients and healthy controls concerned the amount of precipitable components. Elevation of precipitable IgM was found to be the most sensitive parameter (86% above means + 2 SD of normal controls, p less than 0.005). Increased amounts of precipitable IgG, C4, and Clq were found in 57-46% of patients' sera. Elevation of precipitable IgA and C3c were identified less often. The results suggest the quantification of precipitable immune complexes and their components to be of value as adjuncts in determining disease activity in Hodgkin's disease.
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PMID:Precipitable immune complexes in Hodgkin's disease. 661 6

The activity of GlcNAc-ase, GlcUA-ase and Gal-ase was determined in the leukocytes serum and urine of 23 patients with M. M., 11 patients with other neoplasms including 9 with lymphoreticular proliferative processes without associated monoclonal gammapathy. The range of normal enzyme activity was established in the investigations carried out in 45 health subjects. In the group of patients with M. M. without complications. normal activity of GlcNAc-ase, GlcUA-ase and Gal-ase was found in the leukocytes. In the group of patients with white blood cell count below 2.5 g/l and in cases after long-term treatment with Alkeran the activity of GlcNAc-ase and GlcUA-ase in the leukocytes was reduced. In the patients with M. M. the activity of GlcNAc-ase was raised in the serum and urine, and this activity was higher in cases with longer duration of the disease and more advanced pathological process. The patients with M-IgG protein showed a higher GlcNAc-ase activity in the serum and urine than those with protein M-IgA. A higher activity of GlcNAc-ase in the serum and urine than those with protein M-IgGK than in those with M-IgG gamma. In patients with M. M with renal complications the urinary activity of GlcNAc-ase was higher than in patients with M. M. without renal complications. In CLL the activity of GlcNAc-ase was found to be decreased in the leukocytes and raised in the urine. In patients with Hodgkin's disease the activity of the studied enzymes was raised in leukocytes while the results of their determinations in serum and urine were equivocal.
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PMID:N-acetyl-beta-glucosaminidase, beta-glucuronidase and beta-galactosidase in the leukocytes, serum and urine of healthy subjects and patients with immunocytoma. 677 53

Presence of heavy chains (Mu, Gamma, Alfa) of immunoglobulins in plasma cells, in plasma cell precursors and in atypical cells (Sternberg-Reed-, Hodgkin's cells and mirror image cells) was studied by immunoperoxidase technique. In 7 cases all types of the mentioned cells revealed a strongly positive IgG reaction. In 16 cases in atypical cells beside the moderately positive IgG reaction a mild reaction of IgA has also been seen. In these cases only a few plasma cell precursors (plasmoblasts,immunoblasts) have occurred. Considering the first group of patients it can be supposed that atypical cells develop from the plasma cell precursors.
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PMID:[Intracellular immunoglobulins in lymphogranulomatosis]. 679 Sep 44


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