Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The spectre of methods for the diagnostics and differentiation of haemolytic anaemias, particularly for the establishment of congenital, autoimmune haemolytic, drug-conditioned and other anaemias is treated. The clear delimitation of an iron deficiency from a disturbance of the iron distribution is advantageously to be achieved by iron staining of the bone marrow and by a determination of serum ferritin. The value of the diagnostic methods in megaloblastic anaemia is classified according to newer knowledge, in which case the vitamin-B12-absorption test and the serum level determination of vitamin B12 by no means range in the first place. Long-term culture results of haematopoietic stem cells are particularly evident in the aplastic syndrome of the bone marrow and further haematological diseases concerning the establishment of the intensiveness of proliferation. The classification of the acute leukemias demands conventional as well as cytochemical staining methods; recently, it is essentially improved using monoclonal antibodies. In leukemias cytogenetic investigations are more and more attracted to the estimation of the prognoses. In lymphogranulomatosis among others functional disturbances of the cellular immunity, in the group of the non-Hodgkin-lymphomas haematological, protein-analytic and immunological laboratory investigations are methods supporting the diagnosis. Altogether is to be established that the haematological diagnostics has become more and more perfect, in which case apart from new techniques old approved methods are still further used.
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PMID:[Rational hematologic diagnosis with reference to modern laboratory procedures]. 409 May 58

Antigens which exist in high frequency in tumor tissues of patients with Hodgkin's disease have been obtained in relatively concentrated form by gel chromatography procedures. Further purification and analysis of these antigens performed in the present study have demonstrated that the antigen of fast electrophoretic mobility (F-antigen) is normal tissue ferritin. The identification of F-antigen as ferritin has been made on the basis of comparative physicochemical and immunological analyses of purified F-antigen and normal ferritin. Thus, F-antigen was found to contain iron and to be similar to ferritin in molecular weight, amino-acid composition, electrophoretic mobility, isoelectric distribution, and immunological reactivity. Absorption of a monospecific heterologous anti-F antiserum with normal tissue ferritin completely removed all anti-F antibody activity. Moreover, the absorption of polyspecific heterologous antiserum to crude Hodgkin's extracts, which contains antibodies reacting with F-antigen, the slower migrating S-antigen, and a third specificity present in lysates of normal peripheral blood lymphocytes (PL-antigen), with ferritin, removed only anti-F activity, thus distinguishing the S- and PL-antigens from ferritin. The existence of ferritin in high quantities in serum of Hodgkin's disease patients may provide a tool of potential diagnostic and prognostic importance in the management of this disease.
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PMID:Ferritin, a Hodgkin's disease associated antigen. 413 6

The serum ferritin concentration is increased in both acute myeloblastic leukaemia and Hodgkin's disease. In acute leukaemia the mean concentration is about ten times the normal level and is associated with a high concentration of transferrin-bound iron. In Hodgkin's disease abnormal ferritinaemia is associated with a low concentration of transferrin-bound iron and appears to result from a block of reticuloendothelial iron release. Increased concentrations of circulating ferritin have also been observed in a few cases of chronic leukaemia and myelomatosis.
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PMID:Ferritinaemia in leukaemia and Hodgkin's disease. 451 89

1. Single muscle fibres from frog semitendinosus were subjected to sudden changes in [K](o), while recording membrane potential.2. In agreement with Hodgkin & Horowicz (1960), a sudden increase in [K](o) in normal fibres produced a rapid depolarization (half-time 0.3 sec), whereas a sudden decrease in [K](o) produced a slower repolarization (half-time 2-3 sec).3. Fibres were subjected to ;glycerol-treatment', a procedure which was supposed to produce a functional disconnexion of the T-system from the surface. In these glycerol-treated fibres both depolarization and repolarization induced by changes of [K](o) took place rapidly.4. The results suggest that the slowness of the repolarization in normal fibres is due to a retention of K ions inside the T-tubules.5. Electron microscopical observation of single fibres or bundles of fibres, which have been soaked in a Ringer containing ferritin, revealed that normal fibres contained ferritin particles in the T-system, while glycerol-treated fibres showed no ferritin. Except for the presence of some large vacuoles and some swelling of the T-system, glycerol-treated fibres appeared morphologically normal.6. Prolonged soaking in a high potassium solution produced electrical effects suggesting that K ions can enter the tubules of treated fibres very slowly, in spite of their inaccessibility to ferritin.7. The main effect of glycerol-treatment does not seem to be a total disconnexion of the T-system from the fibre surface, but rather constriction of the T-tubules near their openings to the exterior.
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PMID:Speed of repolarization and morphology of glygerol-treated frog muscle fibres. 454 76

Serum ferritin was studied in 4 patients with abdominal Burkitt's lymphoma, 6 with facial Burkitt's lymphoma, 10 with primary hepatocellular carcinoma, 6 with secondary hepatic cancer, 8 with primary breast cancer, 4 with Hodgkins's disease, 3 with chronic lymphocytic leukaemia and 6 with other neoplastic diseases. Control values were determined for 23 apparently healthy Nigerians. Serum ferritin was significantly elevated in patients with Burkitt's lymphoma (facial and abdominal combined), primary hepatocellular carcinoma, secondary hepatic cancer, chronic lymphocytic leukaemia (p less than 0.00001), Hodgkin's disease and in other neoplastic diseases as compared to the control (p less than 0.0004). Serum ferritin levels were significantly elevated (p less than 0.00001) in abdominal Burkitt's lymphoma but less dramatically elevated values or even values within the reference range (mean + 2 Standard Deviations of the controls) were seen in the values of serum ferritin in the patients with facial Burkitt's lymphoma. The assay of serum ferritin may be of some value in the diagnosis and classification of patients with Burkitt's lymphoma, and in monitoring the treatment provided.
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PMID:Serum ferritin in Nigerian patients with Burkitt's lymphoma and other malignant diseases. 613 56

Ferritins, a group of isomeric proteins that have important functions in iron metabolism and storage, have been demonstrated to be carcinoembryonic antigens. It has been recently shown that a subpopulation of lymphocytes from the peripheral blood of patients with Hodgkin's disease or breast cancer bear ferritin on their surface membranes. In view of the potential diagnostic and prognostic value of ascertaining the number of ferritin-bearing lymphocytes, the authors developed a simple indirect immunofluorescent technique for identifying them and used this technique to examine the peripheral blood lymphocytes of 44 patients with carcinomas of the head and neck (26), colon (14), and lung (4). It was found that patients with cancer had a mean percentage of 10% ferritin-bearing lymphocytes in their peripheral blood as compared with 3.1% in controls. Ferritin binding did not appear to be influenced by a cell's capacity to form sheep erythrocyte (E) rosettes since no correlation could be found between the percentages of lymphocytes bearing ferritin and those forming three different varieties of E-rosettes. There appeared to be no correlation of the percentages of ferritin-bearing lymphocytes with clinical staging except for a small, but significant (P less than 0.05), increase in the number of patients with head and neck cancer and nodal metastases. Although the functional significance of ferritin-bearing lymphocytes is currently unknown, the appearance of this subpopulation of cells in the blood appears to be associated with cancer. This assay may prove to be useful as a diagnostic tool, as a prognostic tool, or as a means of identifying patients at a risk for developing cancer and, therefore, it deserves further exploration.
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PMID:Ferritin-bearing lymphocytes in patients with cancer. 636 Mar 36

A comprehensive immunologic and serologic analysis was performed on 31 untreated patients with Hodgkin's disease. Immune evaluations stressed T-cell functional activity and included traditional parameters (PHA responsiveness and delayed hypersensitivity skin reactivity), as well as newer functional assays (T-cell colony formation, chemotaxis, spontaneous and antibody-dependent cytotoxicity, and concanavalin A-induced suppressor cell activity (CISA). Serum factors included ferritin, prostaglandins, zinc, copper, immune complexes, and thymic hormone activity. Every patient exhibited at least one T-cell or serum abnormality. The greatest percentage of patients exhibited T-cell defects in chemotaxis (85%), colony formation (81%). and PHA reactivity (64%). Immune defects were more common with advanced disease but were not related to absolute T-cell or monocyte count, skin test anergy, or abnormalities of T mu/T gamma cell proportions. Linear relationships were identified among abnormalities in the three assays employing mononuclear cells (PHA, colony formation, CISA) which may have reflected the inhibitory influence of monocytes present in the mononuclear cell preparations. Low serum zinc correlated with marked impairment of T-cell chemotaxis. Elevated prostaglandins were associated with high PHA reactivity and with depressed colony formation. Our results indicate that many complex factors, including intrinsic T-cell defects, contribute to the impaired immunity associated with Hodgkin's disease.
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PMID:Multivariate analysis of T-cell functional defects and circulating serum factors in Hodgkin's disease. 645 60

Using 125I-labeled rabbit anti-Hodgkin's spleen ferritin antibody (RHF), a simple radioimmunoassay has been developed for quantitation of ferritin on the surface of peripheral blood mononuclear white blood cells (PBM). This method makes use of a % specific binding determination (%SP) by measuring the amount of 125I-labeled RHF bound to 1 X 10(6) PBM in the presence and absence of soluble ferritin. To standardize this procedure, artificial ferritin positive control cells were prepared by covalently coupling ferritin to cultured acute lymphoblastic leukemia cells. These cells were tested on a daily basis in parallel with patient PBM's to ensure inter and intra-assay precision and remained stable for over two years. Characteristics of 125I-labeled RHF binding to control and patient PBM's were evaluated to determine the specificity of interaction and optimum binding parameters. %SP was linear in the range of 1 X 10(5) - 1 X 10(6) PBM's and was progressively inhibited by graded concentrations of soluble ferritin. F(ab')2 preparations of RHF were equally as effective as intact RHF in blocking 125I-labeled RHF binding confirming that 125I-labeled RHF was not binding non-specifically to PBM Fc receptors. Additional experiments describing kinetics and methods of standardization of new lots of 125I-labeled RHF are also described.
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PMID:Characteristics of a specific radioimmunoassay for measurement of ferritin on the surface of peripheral mononuclear white blood cells in cancer patients. 653 Apr 82

Biosynthesis of ferritin subunits by cell sets isolated from normal human peripheral blood, spleens of Hodgkin's disease patients, and tumor cell lines were investigated. Normal mature hematopoietic cells made a ferritin with more H (21K) than L (19K) subunits. The reverse was found for a promyelocytic tumor cell line and tumor cell lines derived from other tissues. Two dimensional electrophoresis indicated H has a lower pI than L. Therefore relative proportions of the two subunits contribute to the electrophoretically distinct forms of the isoferritins. In response to increasing concentrations of iron in vitro, a selected monocyte population synthesized more H than L; L biosynthesis however increased more than H. Some possible regulatory implications of these observations are discussed.
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PMID:Relative subunit composition of the ferritin synthesized by selected human lymphomyeloid cell populations. 660 68

In the haematological malignant diseases, especially Hodgkin's disease and other lymphomas, many of the disturbed biological tests reflect the inflammatory process and therefore lack any specificity. Of particular interest are blood sedimentation, the protein-C-reactive test, serum iron, transferrin, serum copper and ferritin. Other tests such as lactic dehydrogenase and beta 2-microglobulin appear to be in the nature of "markers". In 118 patients, serum levels of beta 2-microglobulin above 2.50 mg/l were observed in 83% of the lymphoproliferative disorders and also in 16% of patients without malignant diseases. However, the highest values (greater than 5.00 mg/l) were observed only in 12 patients with lymphoproliferative disorders and 1 patient with "acquired immunodeficiency syndrome".
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PMID:[Usefulness of biologic tests in malignant hemopathies]. 661 75


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