Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The light chain of serum IgE from 4 untreated patients with Hodgkin's disease with elevated IgE levels was studied by an immunoadsorbent technique. Serum IgE was found to contain both kappa and lambda light chains in all cases studied. In addition an association between serum levels of IgE and that of IgA, IgG, and IgM was demonstrated. These findings make it unlikely that increased serum IgE in Hodgkin's disease is of monoclonal origin and support the view that serum IgE in such patients reflects a general disturbance in the regulation of their humoral immune response.
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PMID:Increased serum IgE in Hodgkin's disease is of polyclonal origin. 12 Oct 23

Serum levels of IgE in malignant lymphogranulomatosis (Hodgkin's disease) were lowered in patients who had been intensively treated, without eosinophilic granulocytes, and in less advanced forms of the disease. High levels were observed in untreated patients with eosinophilic granulocytes in their peripheral blood, and in clinically advanced cases.
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PMID:Serum levels of IgE in malignant lymphogranulomatosis. 30 33

Serum IgE concentrations were determined and IgE turnover studies were performed in control individuals as well as in patients with several disease states. Patients with common variable hypogammaglobulinemia, thymoma and hypogammaglobulinemia, ataxia telangiectasia, and selective IgA deficiency had significantly decreased mean serum IgE concentrations. In turnover studies, this was found to be due to decreased IgE synthesis. In spite of these depressed mean values, some patients with common variable hypogammaglobulinemia had normal serum IgE concentrations and synthetic rates. Patients with the Wiskott-Aldrich syndrome had a significantly elevated mean serum IgE concentration. In one of four patients studied with the turnover technique, a strikingly high IgE concentration was present and was associated with an elevated IgE synthetic rate. Three other patients had both normal serum IgE concentrations and synthetic rates. Patients with chronic lymphocytic leukemia had significantly decreased mean serum concentrations and synthetic rates for IgE. The depressed IgE synthesis was associated with a significantly prolonged IgE half-life. Patients with Hodgkin's disease had significantly increased serum IgE concentrations. One of three patients studied had a high serum IgE concentration and synthetic rate of IgE. The two other patients had normal serum IgE concentrations associated with normal synthetic rates. Finally patients with protein-losing enteropathy or familial hypercatabolic hypoproteinemia had normal IgE concentrations associated with normal IgE metabolic parameters. In these cases, the disorder in the catabolic rate was not severe enough to affect the total amount of circulating IgE because IgE normally has a very high fractional catabolic rate. In general, IgE levels in a variety of disease states were correlated with IgE synthetic rates and abnormalities in the catabolic rate of IgE in disease did not exert an important effect on IgE concentration.
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PMID:The metabolism of IgE in patients with immunodeficiency states and neoplastic conditions. 40 20

Serum immunoglobulin levels were measured in 105 patients with untreated Hodgkin's disease (HD) and 80 with non-HD lymphomas. Significant increases in IgG and IgE occurred in the whole HD group. When compared with the histological types of HD, increases of IgG, IgA AND IgE were seen in nodular sclerosis and of IgE alone in mixed-cellularity and lymphocyte-predominant types. In relation to the stage of disease spread, increases of IgG, IgA AND IgE occurred in Stages II and III, while in Stage IV, although IgE was raised, IgM in males and IgD fell significantly. Paired serum samples taken 10-14 months apart showed falls of IgM and IgD after radiotherapy, and of all Ig classes except IgD after chemotherapy. Decreased levels of IgM in females, IgG and IgA were found in the non-HD lymphomas. When analysed in terms of lymphnode histology, decreased IgG, IgA, IgM and IgE occurred in well differentiated lymphocytic lymphomas, decreased IgA alone in poorly differentiated lymphocytic lymphomas and decreased IgD in nodular types of lymphoma.
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PMID:Serum immunoglobulins G, A, M, D and E concentrations in lymphomas. 50 66

Thymus-derived lymphocytes have been shown to play a role in the regulation of IgE synthesis in the rat. Both anergy and elevated serum IgE levels may be present in patients with Hodgkin's disease. Cell-mediated immunity (CMI) was investigated by measurement of delayed skin test reactions with five common antigens. Serum IgE levels were determined at the same time. Impaired CMI was more prevalent in patients in stage III (13 of 15) and IV (15 of 19), as compared to patients in stage I and II (9 of 17). All 12 patients with elevated serum IgE levels (greater than 300 U/ml) had impaired CMI. These findings strongly suggest a relationship between impaired CMI and serum IgE in Hodgkin's disease patients.
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PMID:Relationship of serum total IgE and cell-mediated immunity in patients with Hodgkin's disease. 59 Nov 7

IgG, IgA and IgM were determined in 68, and IgE in 30 patients with Hodgkin's disease. Their relation to the dissemination stage, histological type, clinical stage and peripheral lymphocytes as well as the correlation of IgE to the peripheral eosinophils was investigated. In the untreated collective all Ig concentrations were above normal, but in the treated patients only IgG and IgE. With increasing dissemination, there was a decline of IgG, IgA and IgM in both groups which, however, was only significant for IgM. IgM was lowered in the lymphocytopenic type, raised in nodular sclerosis. There is a confirmed correlation between the absolute peripheral lymphocytes and IgM and between the peripheral eosinophils and IgE. IgE and IgA are slightly and IgM significantly lowered in the treated compared with the untreated patients. The findings suggest a disturbance of the humoral immunity in stage IV, in the lymphocytopenic type and in the treated patients.
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PMID:[Immunglobulins G, A, M, and E in lymphogranulomatosis (author's transl)]. 81 17

Serum IgE levels were determined in a retrospectively selected group of 37 patients with Hodgkin's disease. IgE was determined by a double-antibody radioimmunoassay and expressed as International Units/ml. Patients were analyzed by stage and histologic classification of disease and compared to a group of 102 normal controls. IgE levels for the total group with Hodgkin's disease were significantly higher (p = .02) than controls but there was considerable overlap in ranges. Significant elevation of IgE was found in nodular sclerosing (p = .005) and Stage II Hodgkin's disease p = .0025). IgE elevations seen in other stages and histologic classes were not significant. While not conclusive, the IgE elevations that were found would be consistent with a suppressor T cell dysfunction in Hodgkin's disease.
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PMID:IgE levels in Hodgkin's disease. 99 61

Tissues containing Hodgkin's disease (HD) are frequently infiltrated by large numbers of eosinophils. Because eosinophils as well as Reed-Sternberg (RS) cells express membrane receptors (CD23) for IgE, this study was performed to determine if IgE is present in tissue sections of HD and to correlate the results, when possible, with serum IgE levels and the presence of interleukin-5 (IL-5) messenger RNA (mRNA) in RS cells. Paraffin-embedded, B-5-fixed slices of 13 cases of HD, one case of acquired immunodeficiency syndrome (AIDS)-related HD, seven cases of benign lymphoid hyperplasia (including two cases from HD patients), and five cases of B-cell lymphomas were analyzed by a sensitive immunoperoxidase staining technique that used a murine monoclonal antibody specific for human IgE. In the benign hyperplastic lymph nodes and non-Hodgkin's lymphomas, IgE was generally detectable only in rare plasma cells and in follicular dendritic cells. In 11 of the 14 cases of HD, including one case of AIDS-related HD, IgE was readily detectable within RS cells and variants and on the surrounding cells and connective tissue. These cases also had significant numbers of eosinophils, and IL-5 mRNA was detectable in three of the cases that were tested. Serum IgE was moderately elevated in the two serum specimens from HD patients that were available for analysis. The results of this study, therefore, indicate that some cases of HD contain abundant deposits of IgE, which may account for the extensive infiltration by eosinophils seen in this neoplasm.
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PMID:IgE in Reed-Sternberg cells of Hodgkin's disease with eosinophilia. 153 40

The leucocyte antigen CD23 is upregulated in the early stages of B-cell activation by Interleukin-4 (IL-4), and functions as an IgE receptor and lymphocyte growth factor. We have studied the expression of CD23 in 68 cases of non-Hodgkin lymphoma (NHL) using the antibody BU38. This new antibody has the great advantage of being applicable to routinely-processed paraffin sections. CD23 was expressed in tumour cells in 27 out of 36 cases of low grade NHL and 3 out of 32 cases of high grade NHL. Follicular dendritic cells were strongly positive and were seen in follicular lymphomas. Macrophages were also positive and were numerous in high grade lesions.
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PMID:CD23 expression in non-Hodgkin lymphoma: immunohistochemical demonstration using the antibody BU38 on paraffin sections. 174 98

Thirty one lymph nodes taken from 24 benign reactive cases, three cases of angiolymphoid hyperplasia with eosinophilia, one case of Kimura's disease and three cases of Hodgkin's disease, were stained for immunoglobulin heavy chains IgG, IgM, IgA and IgE using the peroxidase-antiperoxidase method. Reticular staining of germinal centres and cells containing immunoglobulin in germinal centres and extrafollicular regions were features of all groups. No staining pattern was diagnostic for any of these conditions and in particular, the reticular staining pattern of IgE in the germinal centres that is frequently reported in Kimura's disease and in angiolymphoid hyperplasia with eosinophilia was non-specific.
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PMID:Immunoglobulin heavy chain patterns in reactive lymphadenopathy. 191 3


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