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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The increased incidence of parallel tubular structures in lymphocytes of patients with Hodgkin's disease was investigated for a correlation with either impairment of cellular immunity (measured by DNCB-skin test and PHA-induced lymphocyte stimulation in vitro) or an increase of antibodies against cytomegalovirus or Epstein-Barr virus. No correlations were found. Statistical analysis revealed antibody titers especially in the group of patients with high percentages of lymphocytes containing the tubular inclusions. This probably reflects only the connection between these findings and the progression of the disease. The nature and function of the parallel tubular structures have to be investigated further. In Hodgkin's disease they may have significance for the understanding of an alteration in lymphocyte function and morphology.
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PMID:Parallel tubular structures in lymphocytes. II. Correlation with cellular immunity and cytomegalovirus and Epstein-Barr virus antibodies in Hodgkin's disease. 16 60

The cellular immune response was explored by us with the help of tuberculin and DNCB reactions in 73 cases of Hodgkin's disease. Serum immunoglobulins were simultaneously determined. Tuberculin and DNCB reactions had significantly been decreased before treatment. A significant augmentation of the IgA is remarkable in tuberculin and DNCB positive groups. The positivity of the cutaneous tests is only temporarily lowered by radiation therapy, the difference being not significant, while IgM values in patients who had undergone radiation therapy are remaining at a lower level. Patients in remission revealed a positivity in tests that was approximating the values before treatment. Lower values were observed in all the three groups of immunoglobulins; the decrease of the IgM-values was significant. In case of a relapse, a significant decrease of positivity developed, accompanied by significantly increased values of IgA in tuberculin and DNCB negative groups. Only insignificantly positive values of the cutaneous tests were seen in the course of cytostatic treatment, and the values of the IgM were significantly decreased.
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PMID:[Cellular immune response and concentrations of serum immunoglobulins in patients with Hodgkin's disease (author's transl)]. 44 17

Immunological test alterations in Hodgkin's disease are described. Cutaneous reactivity to various antigens (tuberculin, oidiomycin, trichophytin, parotitis virus, candida, etc.), cutaneous reactivity to sensitizing chemical agents (DNCB, DNFB), lymphocyte blastization in vitro with PHA and various antigens, the reaction of homologous lymphocytes transferred to the skin, and the stimulation by the Hodgkin lymphocytes of homologous lymphocytes in unidirectional mixed culture, are all impaired. Antibody immunity would appear to be normal. The impairment of the T system and normality of the B system would explain these patients' much greater susceptibility to viral than to bacterial diseases. On the basis of the most recent research, it is hypothesized that underlying these phenomena is a deficiency in the H-LA system which makes it unable to recognize certain neoplastic antigens (Reed-Strenberg reticular cells, for example); stimulation of the B system by the formation of anti-T antibodies and subsequent depletion of this system.
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PMID:[Immunological aspects of Hodgkin's disease]. 107 22

Multiple in vivo and in vitro immune parameters were used to examine 52 untreated patients with Hodgkin's disease in all stages. A significant number (p less than 0.01) of patients in all stages demonstrated abnormalities in DNCB sensitization, peripheral blood lymphocyte response to phytohemagglutination, absolute lymphocyte count, absolute number of T cells (as measured by spontaneous rosette formation with sheep erythrocytes), and absolute number of B cells (as measured by immunofluorescence with polyvalent antiserum). The number of T and B cells fell progressively with each stage, but the proportion of T to B cells remained constant. Cutaneous anergy was found in STAGES III and IV. Depressed circulating immunoglobulins were found in a few patients in all stages. Neither the total lymphocyte number nor the number of T and B cells correlated with the measures of lymphocyte function (skin test reactivity, DNCB sensitization, mitogen response, or immunoglobulin levels). This study suggests that selective abnormalities in the immune system exist even in early Hodgkin's disease, involving the absolute number of circulating T and B lymphocytes and T-lymphocyte function. The study fails, however, to define a consistent pattern of immune defects as characteristic of Hodgkin's Disease.
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PMID:Comparison of multiple in vivo and in vitro parameters in untreated patients with Hodgkin's disease. 108 8

A chemical plant, where an increased number of non-Hodgkin's lymphomas and myelomas had been observed, was monitored for genotoxic effects occurring in peripheral mononuclear leukocyte samples from 76 exposed workers. Biochemical markers sensitive to DNA repair and drug metabolism were used as the indicators of genotoxic risk. Unscheduled DNA synthesis (UDS) and covalent binding induced by N-acetoxy-N-acetyl-2-aminofluorene (NA-AAF) and constitutive and gamma ray induced adenosine diphosphate ribosyl transferase (ADPRT) activities were highly and significantly elevated over the corresponding values for a control group of 48 postal workers. Microsomal and soluble epoxide hydrolases and glutathione transferase activities directed towards trans-stilbene oxide and 1-chloro-2,4-dinitrobenzene were not significantly altered in the exposed group. The exposure in this factory was complex, involving over 100 chemicals including several well known carcinogens. However, no apparent significant associations to exposure could be established.
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PMID:Biological effects in a chemical factory with mutagenic exposure. II. Analysis of unscheduled DNA synthesis and adenosine diphosphate ribosyl transferase, epoxide hydrolase, and glutathione transferase in resting mononuclear leukocytes. 313 75

Fifteen Hodgkin's disease patients (8 male, 7 female) aged 19-72 years, who had been in complete unmaintained remission for 1 year or more when the study was initiated, were given 50 mg thymostimulin (TS) IM daily for 60 consecutive days. When compared with 26-30 age- and sex-matched controls, as a group the patients' circulating ENR+, OKT+3, and OKT+4 cells were depressed (0.001 less than or equal to P less than or equal to 0.06), whereas their OKT+8 cell population was not. Low (greater than 1 SD or greater than 2 SD below mean in controls) or borderline (mean value of two subsequent tests greater than 1 SD below mean in controls) values of ENR+, OKT+3, and OKT+4 cells were seen in nine (group I) of the 15 patients tested, while the remaining six patients (group II) had normal T-cell proportions. Following TS treatment, the proportions of ENR+, OKT+3, and OKT+4 cells increased to normal in all group I patients. The T-cell levels, however, decreased to pretreatment values 60-70 days after completion of TS therapy. TS had no effect on the group II patients whose T-cell percentages had initially been normal. Spontaneous cell-mediated cytotoxicity (SCMC) was assessed in 11 patients, and irrespective of the baseline values, there was a significant enhancement (P less than 0.005) by day 15 of TS administration, which was maintained during treatment. SCMC, however, returned to pretreatment levels 60-70 days after TS was discontinued. The delayed skin test reactivity to DNCB was significantly depressed in all cases. Although TS restored the T-cell proportions, it failed to reverse DNCB reactivity from negative to positive in any of the patients tested. TS can thus restore defective T-cell frequencies and can enhance cytolytic functions that are potentially important in host immunosurveillance, but it apparently failed to improve the skin reactivity to neoantigen.
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PMID:Immunorestorative properties of thymostimulin (TS) in patients with Hodgkin's disease in clinical remission. 387 9

In 40 cases of Hodgkin's disease (24 untreated patients and 16 patients in remission) the immunological humoral and cell-mediated competence was studied using test of hypersensitivity of DNCB and PPD, blastic transformation and the ability of 3H-DNA synthesis in lymphocytes stimulated with PHA and PWM, and in some cases, with PPD. In all patients the concentration of serum immunoglobulins was determined as well. Impairment of immunological reactivity was found in about 40% of patients, on the average, in various stages of the disease and during remissions following treatment with cytostatic agents and radiotherapy. The most frequent abnormality found in 52.5% of cases was impairment of blastic transformation of lymphocytes stimulated with PHA in vitro. In 60% of cases negative results of intradermal test with PPD and in 75% of patients the DNCB test was negative. No correlation could be found between impairment of the immune competence in this disease and the clinical stage and/or type of histological changes in lymph nodes.
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PMID:Immune condition in patients with Hodgkin's disease. 696 89

87 adult patients with histologically confirmed diagnosis of Hodgkin's disease were examined to analyse the pattern of immune alterations with regard to the clinical stage and course of disease, and the response to treatment. Patients with advanced stages of the disease or with radio- or chemotherapeutically induced remission showed a decrease in total lymphocyte counts and a diminished count of T-lymphocytes. The lymphocyte transformation and the reactions in skin tests with DNCB and microbial antigens were the more disturbed the more the disease was advanced. Below a critical number of circulating T-lymphocytes measuring 500 cells per mm3 of peripheral blood an inhibition of T-cell function has been found. The authors conclude that a positive correlation between an undisturbed immune status and a good prognosis in Hodgkin's disease is highly probable.
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PMID:[Immunological data in the clinical evaluation of Hodgkin's diseases]. 697 41

A skin test to DNCB, the reaction on spontaneous rosette formation, the lymphocyte blasttransformation reaction to PHA, and the leucocyte migration inhibition test were utilized in examining 501 human subjects (157--control group, 41--patients with benign tumors of the mammary gland and lung and 303--patients with cancer of the lung, breast, rectum and lymphogranulomatosis). The results obtained were processed after the V. S. Genes method. The examinations performed revealed no diagnostic value of the tests under study in patients with malignancies, benign tumors and lesions of a non-tumor origin.
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PMID:[Diagnostic value of cellular immunity indices in oncological practice]. 699 37

Immune dysfunction seems to be more common in lymphoproliferative disorders wherein the malignant cells originate from the immune system itself. The reaction of Dinitrochlorobenzene (DNCB) and six recall antigens were found to be diminished in patients with non-Hodgkin's lymphomas as compared to control subjects (P less than 0.005). The skin reactivity was lost in increasing order in well differentiated, poorly differentiated, and histiocytic types. The depression in delayed hypersensitivity was greater with generalized as compared to localized disease. In angioimmunoblastic lymphadenopathy (AIL), skin tests also showed negative response in 7 of 8 patients. This T-cell dysfunction in a preneoplastic condition (AIL) suggests early appearance of immunodeficiency and probably a prerequisite for the development of a lymphoma. The serum immunoglobulin levels failed to show any relation with respect to histology or extent of disease. Presumably, the alteration of IgG is secondary to a malignancy.
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PMID:Immune dysfunction in non-Hodgkin's lymphoma. 737 14


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