Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bipedal lymphography was used as part of the initial staging evaluation of 145 patients with Hodgkin's disease. Histologic correlation was available in 131 patients. The accuracy of interpretation was 95%. A review of other large series confirms that at least 85%-90% accuracy can be expected. Reasons for false positive and false negative interpretations are discussed.
AJR Am J Roentgenol 1977 Dec
PMID:Accuracy of bipedal lymphography in Hodgkin's disease. 41 55

Twenty-seven patients with mediastinal Hodgkin disease were teated either by radiation therapy or chemotherapy. The rates of tumor regression were measured and were fitted into a three-parameter Gompertzian model. Tumor regression was more pronounced and prompt in patients treated with radiotherapy. The Gompertzian model matched the radiation therapy data closely in the first 90 days after initiation of therapy in cases of approximately equal tumor size.
Radiology 1979 Dec
PMID:Regression of Hodgkin disease in the mediastinum: a mathematical model. 50 55

The records of 292 patients with malignant lymphoma other than Hodgkin's disease, registered in our protocols from 1967 to 1977, were reviewed to identify those with central nervous system (CNS) involvement. Thirty-one patients were encountered with this complication, an incidence of 11%. Patients with a diffuse histology had a higher frequency of CNS recurences (27/174 = 16%) in contrast to only 4/118 (3%) for those with nodular types. However, if only patients with diffuse histology in CR are considered, the frequency of CNS relapse is 13.5% (13/98). The risk factors that predict for the development of this complication were studied using multivariate analysis. Diffuse poorly differentiated lymphocytic and diffuse undifferentiated lymphomas were found to be associated with a high risk of CNS relapse. Prior chemotherapy, bone marrow involvement, age less than 35, and extranodal disease were also identified as high-risk factors. Using the information generated by a logistic regression model, patients with malignant lymphoma of diffuse type can be classified into three categories when first seen: low-risk group, intermediate, and high-risk group. CNS prophylaxis is recommended for the intermediate and high-risk group, while only close follow-up is advised for the low-risk group patients who have one adverse characteristic.
Blood 1979 Dec
PMID:Central nervous system relapse in malignant lymphomas: risk factors and implications for prophylaxis. 50 36

A case of fatal acute hepatic vein thrombosis occurred during treatment for Hodgkin's disease. At necropsy no evidence of Hodgkin's disease or obliterative venoocclusive disease of the liver was found. We speculate that Adriamycin, DTIC and/or vinblastine may have been responsible for this unusual disorder.
Cancer 1979 Dec
PMID:Acute hepatic vein thrombosis occurring during therapy for Hodgkin's disease: a case report. 50

An ultrasonic analytical method has been developed which is capable of remote, in vivo differentiation between various types of soft tissue on the basis of differences in their gross histological structure. The method is analogous to that employed in X-ray crystallography and is referred to as ultrasonic diffraction analysis. A clinical trial of this method in the investigation of liver disease in 70 patients is reported, in which a total of 416 ultrasonic diffraction patterns associated with various liver conditions have been analysed and related to independent follow-up information. The existance of a malignant condition of the liver has been identified in 95% of the cases involving focal metastatic deposits and in all of the 11 cases studied where the livers had diffuse malignant involvement. Cirrhosis and secondary involvement of the liver due to Hodgkin's disease have also been shown to exhibit specific tissue signatures which enable them to be differentiated from other hepatic disorders.
Br J Radiol 1979 Dec
PMID:Ultrasonic diffraction analysis in the investigation of liver disease. 52 96

The concentration of 2,3-diphosphoglycerate was increased in whole venous blood of patients with various cancers, including those of breast, ovary, lung and colon, but not rectum, compared with age-matched controls. Higher values, increasing with age, were also found in patients with Hodgkin's disease and other lymphomas. This abnormality is considered to be due to increased synthesis of the metabolite by the tumour tissue.
Clin Biochem 1979 Dec
PMID:2,3-Diphosphoglycerate, a cellular ageing metabolite. 53 62

From 1963 to 1977 at the Istituto Nazionale Tumori at Milan, 112 patients below the age of 16 years with Hodgkin's disease (HD) were observed, representing 13.2% of all the cases of this disease seen during the stated time interval. Eighty-seven of these cases are the subject of the present study. Fifty-nine patients were males and 28 females (2.1:1 ratio). The age range varied from 2 years 10 months to 15 years 10 months (median 10 years). Forty-three (49.4%) children, of whom 35 were males and 8 females, were below the age of 10 years at the onset of their disease. The clinical staging resulted in 34 patients as stage I, 33 as stage II, 13 as stage III and 7 as stage IV. The histologic type was nodular sclerosis (NS) in 49 cases (56.3%), lymphocytic predominance (LP) in 15 cases (17.2%), mixed cellularity (MC) type in 9 cases (10.3%) and lymphocytic depletion (LD) in 8 cases (9.2%). In the remaining 6 cases the histologic classification was not applicable. LP type in 15/15 (100%) patients was associated with stages I and II, and NS in 38/49 (77%) patients was related to stage I and stage II. The latter was also the istologic type most often encountered in patients with stage II disease (23/33 or 70%). Eleven patients have died, and their survival varied from 6 to 47 months (median 30 months). The histologic type was LD in 4 cases, NS in 3 cases, MC in 1 case, and LP in 1 case. In the other 2 nonsurvivors, the histologic type was not identifiable. Of the 23 patients with more than a 5-year survival, 14 (60.8%) had NS HD. As in adults, LP and NS were associated with early stages of the disease and with long survival.
Tumori 1979 Dec 31
PMID:Hodgkin's disease in children. Pathologic study of 87 cases. 54 15

During a preliminary clinical experience (1973-1977) we experimented three different sequences in associating 6 MOPP cycles (CT) with radiotherapy (RT) for the treatment of stage II and III Hodgkin's disease. A total of 55 consecutive previously untreated patients can be estimated to contribute in defining feasibility, immediate results and toxicity of the combined treatment. In this group of patients RT preceded CT in 20 cases (RT-6 MOPP), the opposite sequence (6 MOPP-RT) was preferred in 16 cases, whilst a split-course CT fitting in the RT (3 MOPP-RT-3 MOPP) was employed in 19 cases. Except for the sequence used with respect to irradiation, the CT was carried out in all the cases according to the classical scheme proposed by De Vita et al. (11). RT was effected with 60Co-teletherapy and a wide field or segmental sequential fields, having variable extension depending on the stage ("extended nodal irradiation" for stage II and III cases with lymph node involvement not below L3; "total nodal irradiation" for the remaining cases in stage III). The programmed doses were 45.0 Gy to the involved areas and 40.0 Gy to the clinically uninvolved regions for the RT-6 MOPP and 6 MOPP-RT groups. Doses of 35.0/30.0 Gy were planned for the 3 MOPP-RT-3 MOPP group. The three different groups are not homogeneous with regard to certain important clinical and pathological characteristics; in fact, a higher quota of stage III patients, with systemic symptoms and spleen positivity is present in the 6 MOPP-RT and 3 MOPP-RT-3 MOPP groups. The combined treatment has achieved a complete clinical remission in 18/20 patients in the RT-6 MOPP group (90.0%), in 12/16 patients of the 6 MOPP-RT group (75.0%), and in 17/19 cases in the 3 MOPP-RT-3 MOPP "sandwich" combination (89.5%). The average overall duration of the treatment was 48 weeks for the sandwich combination, 50 weeks for the RT-6 MOPP group, and 56 weeks for the 6 MOPP-RT association. As regards the sandwich combination, both CT and RT took a reasonable length of time to complete. On the contrary, both the medical treatment and irradiation required an excessively long time and were not well tolerated when preceded by either RT or CT in full doses. In particular, myelosuppression was less acute and prolonged in the 3 MOPP-RT-3 MOPP group, whereas the actual doses of CT and RT were higher than those which can be reached with respect to other groups. Three preliminary cycles of CT considerably reduce the target volumes and complications arising from RT. The first CT time gave an objective response greater than 50% in 9/9 cases of the 3 MOPP-RT-3-MOPP group with mediastinal involvement. In this group, rather considerable pulmonary complications were observed in 3/9 patients (33.3%) with respect to the 40% found for the 6 MOPP-RT group (2/5 cases) and the 67.7% for the RT-6 MOPP group (6/9 cases).
Tumori 1979 Dec 31
PMID:Feasibility of different combinations of chemotherapy (6 MOPP) plus radiotherapy in Hodgkin's disease. 54 16

Nodular sclerosis (NS) Hodgkin's disease was pathologically subdivided by cellular composition and degree of fibrosis in a series of 49 children admitted to the Istituto Nazionale Tumori of Milan between 1967 and 1977. NS showed lymphocytic predominance (LP) in 26 cases, mixed cellularity (MC) in 16 cases, and lymphocytic depletion (LD) in 7 cases. "Early fibrosis" (EF) and "advanced fibrosis" (AF) subgroups in 28 and 21 cases, respectively, were observed. Of the cases with LP 76.9% (20/26) presented with stages I and II disease, compared with 37.5% (6/16) and 28.6% (2/7) of the MC nad LD subgroups, respectively. LP and EF subgroups coexisted in 12 of 28 (42.9%) patients at stages I and II. Predominance of lymphocytes, rarity of lacunar cells, and a mild degree of fibrosis were asociated with early stages of disease. This data confirms that subclassification of NS is feasible.
Tumori 1979 Dec 31
PMID:Histologic subclassification of nodular sclerosis Hodgkin's disease. 54 17

The authors, according to their experience of repeated controls of abdominal computed tomography (CT) in 10 patients with Hodgkin's and non Hodgkin's lymphomas, obtained a clear demonstration of therapy response and disease evolution. The reduction or enlargement after therapy of periaortic, pericaval, hepatic, splenic and pancreatic lymph nodes not always opacified from lymphographic contrast medium is evaluated. It was possible, during the same examination, to evaluate liver, spleen, kidneys parenchyma and regional bone. CT results were always well correlated with clinical findings.
Tumori 1979 Dec 31
PMID:[Computerized tomography of lymphomas: a simple method in the control of abdominal localization after treatment]. 54 18


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