Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An increase in the serum copper (Cu++) level has been described as a sensitive index of disease activity in several hematologic and nonhematologic malignancies. In order to explore the diagnostic value of Cu++ compared to other hematochemical parameters frequently abnormal in malignancies, Cu++, serum alpha2 globulin (alpha2), plasmatic fibrinogen (Fibr), the erythrocyte sedimentation rate (ESR), and serum iron (Fe++) have been detected and evaluated in 267 patients affected with the following diseases: Hodgkin's lymphoma (HL), non-Hodgkin's Lymphomas (NHL), Acute Leukemias (AL), Chronic Myeloid Leukemia (CML), Chronic Lymphocytic Leukemia (CLL), Myeloma (MM), and Breast Cancer (BC). The best correlation between Cu++ increase and disease activity has been found in HL, NHL, AL, and BC. In these diseases, when the considered parameters were compared, Cu++ and ESR showed a similar pattern, i.e., a high frequency of abnormalities in active disease. It is concluded that Cu++ represents a good complement to some other aspecific parameters in evaluating the activity and diffusion of neoplasias and the therapeutic results, particularly in HL, NHL, AL and BC.
 ...
PMID:The diagnostic value of serum copper levels and other hematochemical parameters in malignancies. 7 79

Serum copper and erythrocyte sedimentation rate were recorded in 54 patients with active Hodgkin's disease and at 186 occasions in 78 patients during stable complete remission. Relatively high and age-dependent normal limits for erythrocyte sedimentation rate were used. Each of the tests was elevated in 70% of patients with active disease. During remission serum copper was elevated in 14% and erythrocyte sedimentation rate in 16.5% of the determinations. Thus the two tests are considered not far from equal in their ability to discriminate between presence and absence of specific disease activity in Hodgkin's disease. Simultaneous elevation during remission occurred in less than 5% of the recordings as compared to 61% during active disease. It is therefore concluded that serum copper level may be of some value as a supplement to erythrocyte sedimentation rate.
 ...
PMID:Serum copper compared to erythrocyte sedimentation rate as indicator of disease activity in Hodgkin's disease. 45 49

Serum copper levels (SCL) which are concomitantly related to red blood cell free copper are significantly increased in some malignant lymphomas in the phase of activity. This results in a profound inhibition of red cell key glycolytic enzymes, hexokinase (Hx) being the most sensitive. Fifteen patients (eight with Hodgkin's disease and seven with non-Hodgkin's lymphoma) were studied for serum and red cell copper concentrations and Hx activity. The mean red cell life span was determined using 51Cr labelled red cells. The resulting data shows that in active disease an increase in SCL was associated with a decrease in Hx activity and a shortened red cell survival. In these cases there was no evidence of autoimmune phenomena or of direct bone marrow involvement by the disease. It is suggested that the increase in copper levels results in a shortened red cell life span through a copper-induced inhibition of red cell Hx.
 ...
PMID:Metabolic changes in red blood cells in malignant lymphomas. 46 59

Initial and serial serum copper levels (SCL) and erythrocyte sedimentation rates (ESR) of 29 children with Hodgkin's disease were reviewed to determine the relationship of these features to disease activity. Only six of 10 patients who relapsed had SCL greater than adult upper normal levels. Although correction for age increased this to 7, it also increased the number of patients with false positive results to 9 of 19. Although 9 of the 10 patients at relapse had an increase in SCL over the preceding value, almost one-fifth of patients in remission had increases in consecutive SCL greater than the average increase of patients who relapsed. We conclude that SCL, even when age corrected and consecutively followed, are not useful as indicators of disease activity in children with Hodgkin's disease. Although the ESR increased to greater than 20 mm/hour in 9 of 10 patients who relapsed, this determination could not be considered a useful early indicator of disease recurrence since it was so frequently elevated in patients who were free of disease (62 of 109 determinations). The extremely nonspecific nature of SCL and ESR in childhood renders these tests unreliable, particularly in the individual child.
 ...
PMID:Value of serum copper levels and erythrocyte sedimentation rates as indicators of disease activity in children with Hodgkin's disease. 70 39

Copper directly reactive with diethylditiocarbamate, ceruloplasmin, monoamine oxidase (SMAO) and diamine oxidase of the serum (SDAO) were studied in healthy subjects, in nine months pregnant women and in some pathological conditions. Increased values of copper were found in pregnancy. Ceruloplasminaemia was increased in hyperthyroidism, congestive hearth failure, Hodgkin's disease, and in pregnancy. Ceroluplasminaemia was strongly reduced in Wilson's disease. SMAO was increased during pregnancy. Statistical analysis showed no correlations between the variations of the data in different pathological conditions. In healthy subjects and in pregnant women, correlation was found between the values of ceruloplasmin obtained using both enzymatic and KCN methods. Statistical analysis of regression lines obtained in both groups of patients showed significative differences between slopes and elevations. It is possible that ceruloplasmin in pregnant women has different composition compared with healthy controls.
 ...
PMID:[Correlation between serum values of copper, ceruloplasmin, SMAO, SDAO, in health- subjects, in pregnant women and in some pathological conditions (author's transl)]. 82 61

Serum copper determinations were routinely performed in 141 men and 100 women with histologically verified Hodgkin's disease, admitted to the Radium Centre for Jutland over a 10-year-period from January 1, 1963, to January 1, 1973. The previously described variations in serum copper with the activity of the disease, increasing with progression and decreasing with improvement, were amply substantiated. Furthermore, the present study showed that the serum copper value at the first admission, before treatment, is statistically significantly correlated to the stage of the disease and consequently probably to the amount of tumor tissue. In men there was also a statistically significant correlation of se Cu to the histologic grade of the bioptic material (classification according to Lukes 1966). In women the correlation was blurred by the effect on serum copper of estrogen, mainly from contraceptive pills and pregnancy. The serum copper is regularly reduced to within normal limits at complete remission; thus, it is proposed that this parameter be included in the criteria for complete remission.
 ...
PMID:The clinical usefulness of serum copper determinations in Hodgkin's disease. A retrospective study of 241 patients from 1963-1973. 94 17

During the past two years, several electronic portal imaging systems have been introduced to the market by therapy accelerator manufacturers and other vendors. While these systems differ substantially in their detection technology, they are all capable of displaying portal images on a video screen in near real-time, and of creating multiple static (or "movie") images during each treatment. Major questions confront the users of such systems as to the best utilization of this wealth of information, and to its value in comparison to traditional weekly portal film methods. Using an "in-house" video based system, a new technique was established to aid in the assessment of on-line images so that immediate "go/no-go" decisions can be made by the therapy technologist. A video "movie-loop" is displayed which consists of the static image of the initial (approved) set-up, and the current treatment image. Multiple images of successive treatments can also be viewed in this "time-lapse" display mode to provide a quick visual means for review of an entire course of therapy. The on-line imaging system hardware is composed of a combination copper-plate/fluorescent-screen detector, a front surface mirror angled at 45 degrees to remove the camera from the direct radiation beam, and a high sensitivity SIT video camera. This assembly is attached to a rigid base and mounted directly to the isocentric gantry. The geometry is fixed to within +/- 1 mm and assures the precise day-to-day reproducibility which is necessary for the success of the time-lapse display technique. Experience with this technique shows it to enhance the user's ability to notice small changes in patient's position with respect to the radiation field. Radiation treatment sites reviewed using this procedure were Hodgkin's (mantle), Lung, Brain and extremities. Shifts in patient position on the order of several millimeters were readily detectable, as will be demonstrated in this paper. Somewhat surprisingly, grosser movements (greater than 1 cm) were also noted despite overall technical excellence as assessed by weekly portal filming. The eye senses day-to-day movement with greater ease when the fields are seen in time-lapse display than when compared as discrete portal images. Ultimately, persistent movement appreciated on the time-lapse display can suggest the need for a change in patient set-up or immobilization technique.
 ...
PMID:Assessment of geometric treatment accuracy using time-lapse display of electronic portal images. 155 66

The serum levels of Ceruloplasmin (CER), Properdin Factor B (PFB) and Copper (CU) were evaluated in a series of 40 patients with Hodgkin's Disease and 46 patients with non-Hodgkin's lymphoma. Concentrations of CER and PFB were determined by rate nephelometry and CU concentrations by the bathocuproine colorimetric method. The results obtained demonstrated that CER, together with the well documented CU, can be used for monitoring Hodgkin's Disease.
 ...
PMID:Serum levels of ceruloplasmin, properdin factor B and copper in lymphoma patients. 179 12

Bone marrow involvement was seen in 11 percent of patients with Hodgkin's Disease which was determined from pre-treatment biopsy specimens using established histopathologic criteria. Analysis of 32 evaluable patients with marrow involvement showed male preponderance with a peak in fourth decade of life. Twenty four cases (75%) had B-symptoms and 15 (46%) presented within six months of onset of symptoms. On categorizing for clinical staging, 21 (65%) belonged to stage III and IV. Hepatomegaly (greater than or equal to 2 cms) was present in seven cases (21%) and splenomegaly in 13 cases (40%). Mixed cellularity and lymphocytic depletion histopathologic subtypes showed the highest frequency of involvement (21 cases; 65%). Out of 28 cases ESR was raised in 27 cases (96%). Eighteen cases (56%) showed elevated serum alkaline phosphatase levels. Serum copper levels were determined in 14 cases, out of which 12 (85%) showed elevated levels. These parameters along with anemia (hemoglobin of 12 g/dl or less) in 26 cases (81%), correlated well with the disease activity. Only four cases had leukopenia at presentation pointing to no hindrance for aggressive chemotherapy. All cases received minimum of six courses of standard combination chemotherapy with or without local radiotherapy. Sixteen cases (50%) relapsed subsequently and were managed accordingly. A five year follow-up revealed a minimal 31 percent overall survival, and 18 percent of patients were disease free and well since the time of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Hodgkin's disease with bone marrow involvement. 259 99

A multivariate analysis of the prognostic factors for clinical Stages I and II supradiaphragmatic Hodgkin's disease was carried out with a logistic regression model in 341 patients. The proportion of patients with positive staging laparotomy was greater in males, in individuals with several sites involved, mixed cellularity (MC) or lymphocyte depletion (LD) histologic types, systemic symptoms, or in patients with lower cervical involvement and higher erythrocyte sedimentation rate (ESR), serum copper, and LDH levels. Histology, presence of systemic symptoms (fever and sweats), and number of involved nodal regions were independent predictors of positive laparotomy. Mediastinal involvement is correlated to a significantly lower risk of positive laparotomy. Based on these observations, the individual risk for each patient of occult abdominal disease has been defined.
 ...
PMID:Individual risk of abdominal disease in patients with stages I and II supradiaphragmatic Hodgkin's disease. A rule index based on 341 laparotomized patients. 270 87


1 2 3 4 Next >>