Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied a subpopulation of the thymus-dependent rosette-forming lymphocytes from the peripheral blood of normal individuals and of untreated patients with solid tumors or hematological cancers. This subpopulation of the thymus-dependent rosette-forming cells (T-RFC), termed the "active T-RFC," may be relatively more immunocompetent than the total thymus-dependent population. The mean percentages and absolute numbers of active T-RFC of 40 healthy adult controls were 25.8 +/- 4.3 and 626 +/- 213, respectively. There was no difference in the percentage of active T-RFC between the controls (smokers and nonsmokers) and the 102 untreated patients with solid (localized or metastasized) tumors, 4 patients with Hodgkin's disease, or the 10 patients with non-Hodgkin's lymphomas. However, the absolute number of active T-RFC was significantly less in the cancer patients than in the controls. Eight patients with chronic lymphocytic leukemia had lower percentages but higher absolute numbers of active T-RFC, whereas 6 patients with multiple myeloma had higher percentage and lower absolute numbers than the controls. Following radiation therapy, 61 patients with solid tumors showed no difference in the percentage of active T-RFC, but the corresponding absolute numbers declined significantly. A good correlation was seen with patients having positive microbial skin test responses and normal percentage of active T-RFC. The significance of both the percentages and absolute numbers of active T-RFC and their relationship to patient status are discussed.
Cancer Res 1976 Sep
PMID:Active T-rosette-forming cells in the peripheral blood of cancer patients. 108 31

To determine the frequency and clinical characteristics of infection with Coccidioides immitis in immunosuppressed patients at Stanford University Hospital, clinical records of 14 years were examined. Thirteen cases met the diagnostic criteria. Half had Hodgkin's disease. In six the infection was disseminated; five of the six died early in the course of their infectious illness, frequently without diagnosis. Conclusions include: 1. The occurrence of coccidioidomycosis in immunosuppressed patients seen at institutions in or adjacent to the endemic area is not as rare as the literature suggests. 2. Dissemination is frequently explosive and the radiographic appearance of pulmonary involvement may appear late. Widespread pulmonary dissemination may occur within 24 hours after a negative x-ray. 3. Although the skin test loses its diagnostic value, the serology remains valid. Thus immunosuppressed patients with febrile illnesses (with or without radiographically evident pulmonary involvement) who have a history of travel to an endemic area should have serological examinations. 4. Lymphocytopenia correlates with risk of dissemination of coccidioidomycosis. 5. The administration of immunsuppressive chemotherapy correlates with such risk while radiotherapy and the malignant or non-malignant nature of the disease do not.
Medicine (Baltimore) 1975 Sep
PMID:Coccidioidomycosis in compromised hosts. Experience at Stanford University Hospital. 109 99

Tonsils are lymphatic organs carrying out functions of humoral and cellular immunity. They form a local immunologic barrier; they are also involved in general immunologic defence mechanisms. Tonsillectomy or the destruction of tonsils by infections does not reduce the immunoglobulin concentration and antibody titres in peripheral blood. Only the local formation of IgA antibodies against poliomyelitis antigen seems to be impaired at least for a short time. The clinical relevance of this finding is unknown. Signs of defects in immunosurveillance, which were found in some study groups resulting from an increase of the morbidity rates of Hodgkin's disease and thyroid carcinoma, must be considered seriously although there is no statistic evidence for an increase of tumor frequency after tonsillectomy. The indication for tonsillectomy must be decided on clinical findings. Signs for a reduction of local antibody synthesis or for a possible diminuation of immunosurveillance should serve to critical indication.
HNO 1975 Sep
PMID:[Tonsils and immunology (author's transl)]. 110 43

The accepted management of Hodgkin's disease has changed markedly in the past two decades. It should be considered a tumor of unifocal origin and potentially one of the most curable cancers, given early diagnosis, careful evaluation, meticulously accurate staging and aggressive, radical treatment. This requires a team effort, is tedious and expensive, and morbidity and mortality remain significant, but the high yield of long remissions and apparent cures justifies this approach to the problem.
South Med J 1975 Sep
PMID:Current management of Hodgkin's disease. 116 22

Serious morbidity from an elective Hodgkin's disease staging laparotomy was low in this group of 65 patients. Patients with mediastinal involvement alone and patients having histologic findings of nodular sclerosis with unilateral neck disease with or without mediastinal involvement appear to have a low risk for disease discoverable by lararotomy. In these situations, we believe that the staging laparotomy may be optional provided that the apleen and paraaortic areas are irradiated. The laparotomy does enable the radiotherapist to reduce the volume of normal tissue treated, and we think we are safer in omitting pelvic irradiation in the patient with early stage, asymptomatic nodular sclerosis if the negative clinical evaluation of the abdomen is confirmed surgically. The incidence of major treatment change because of the findings at laparotomy was low, two of 30, in our patients with a normal lymphangiogram. There was a high likelihood, nine of 30, of major change of treatment from the staging laparotomy in patients with an abnormal lymphangiogram.
Surg Gynecol Obstet 1975 Sep
PMID:An assessment of staging laparotomy in Hodgkin's disease. 116 72

A photosensitivity reaction to vinblastine sulfate occurred in a patient receiving chemotherapy for Hodgkin disease. Ultraviolet light (UVL) testing revealed a decreased minimal erythema dose (MED), which returned to normal following discontinuation of the drug. Photoreactions to intradermal injections of vinblastine were produced in the patient and in five normal controls with a suberythema dose of UVL. Spectrophotometric studies confirmed absorption of vinblastine sulfate in the sunburn range. The clinical lesions and phototests could not be reproduced through window glass or aminobenzoic acid as sunscreens.
Arch Dermatol 1975 Sep
PMID:Photosensitivity reaction to vinblastine. 116 50

Advanced Hodgkin's disease was considered incurable until 1966. The development of combined chemotherapy has led to intensIVe treatment and to cures. Results obtained in 104 patients treated according to acute leukaemia group B protocols are discussed. Staging according to the Rye classification was used, as these patients were treated from 1966 to 1971. Methodology and dosage schemes are discussed. Reponse rates reached 88%, with extended survival. The modifications of therapeutic schedules which led to long-term, unmaintained remissions, are explained. The 5-year survival rate of patients with Hodgkin's disease in stages III and iv who responded, was 82,7%. The effect of histological subclassification on the prognosis is considered. The importance of accurate documentation is stressed, and also the use of laparotomy to prove the staging of the disease so as not to deny the patient the benefit of potential cure with chemotherapy.
S Afr Med J 1975 Sep 06
PMID:Towards curative treatment of advanced Hodgkin's disease. 117 25

Survival studies on series of patients with Hodgkin's disease have indicated that localized disease and certain histologic types are associated with a favorable prognosis. The permanency of cure in such instances has seldom been proved by long-term followup and autopsy; there is evidence that the disease may remain dormant for considerable periods, with the attendant risk of recurrence. A case is reported wherein a patient was relapse-free for 18 years prior to fatal recurrence, which was confirmed by autopsy.
Cancer 1975 Sep
PMID:Death from Hodgkin's disease after 18 years' complete remission. 118 67

Delayed skin test responses to several or all of a battery of six antigens were evaluated in 64 patients with disseminated Hodgkin's disease before, during, and after multiple-agent chemotherapy. Before therapy, 53% of patients had one or more positive skin tests, as compared to 55% during intensive chemotherapy, 79% during maintenance therapy, and 100% after discontinuation of all treatment. Pretreatment skin tests were of no value in predicting clinical response to chemotherapy. Response rates, duration of response, and survival were similar among anergic patients and patients with positive skin tests before treatment. There were too few patients who remained anergic after intensive induction chemotherapy to permit a correlation of immunologic reactivity with course. We conclude that skin test responses to recall antigens, before or during aggressive treatment, are more indicative of Hodgkin's disease activity (and also, of the immunosuppressive effects of treatment routines) than of prognosis.
Cancer 1975 Sep
PMID:Correlation of delayed hypersensitivity responses with chemotherapeutic results in advanced Hodgkin's disease. 118 81

1. The electrical activity of Cardiac Purkinje fibres was reconstructed using a mathematical model of the membrane current. The individual components of ionic curent were described by equations which wee based as closely as possible on previous experiments using the voltage clamp technique. 2. Membrane action potentials and pace-maker activity were calculated and compared with time course of underlying changes in two functionally distinct outeard currents, iX1 and iK2. 3. The repolarization of the theoretical action potential is triggered by the onset of iX1, which becomes activated over the plateau range of potentials. iK2 also activates during the plateau but does not play a controlling role in the repolarization. Hwever, iK2 does govern the slow pace-maker depolarization through its subsequent deactivation at negative potentials. 4. The individual phases of the calculated action potential and their 'experimental' modifications were compared with published records. The upstroke is generated by a Hodgkin-Huxley type sodium conductance (gNa), and rises with a maximum rate of 478 V/sec, somewhat less than experimentally observed values ( up to 800 V/sec). The discrepancy is discussed in relation to experimental attempts at measuring gNa. 5. The ole of the transient outward chloride current (called igr) was studied in calculations of the rapid phase of repolarization and 'notch' configuration...
J Physiol 1975 Sep
PMID:Reconstruction of the electrical activity of cardiac Purkinje fibres. 118 7


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