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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a large cooperative study of Ga-67 uptake in non-Hodgkin's malignant lymphoma, 76% of untreated patients showed positive uptake in one or more lesions. The percentage of known individual lesions seen on scan was significantly lower; thus, negative findings at any one site may have much less significance than positive findings. After treatment, the number of lesions seen decreases sharply, but the role of Ga-67 in evaluating response to therapy is uncertain, especially in view of the fairly large number of lesions undetectable before therapy. Histologic type plays a role in Ga-67 uptake. Large lesions are much more effectively detected than small ones. In spite of numerous false-negative results, Ga-67 scanning is a useful method in evaluating the extent of untreated disease and the presence of lesions posttherapy.
J Nucl Med 1978 Sep
PMID:Ga-67 citrate imaging in malignant lymphoma: final report of cooperative group. 69 Jul 1

Between April 1969, and December 1974, 111 consecutive surgically staged I A and II A patients with supradiaphragmatic Hodgkin's disease were treated at the Joint Center for Radiation Therapy. Patients received 3600--4400 rad to mantle and para-aortic--splenic pedicle regions. Median follow-up was 56 months (30--96). Fourteen patients developed relapsing Hodgkin's disease and three patients died of possible treatment-related causes, two with acute myocardial infarctions and one with radiation pneumonitis. Patients with mediastinal enlargement greater than one third of the chest diameter have a significantly higher risk (p less than 0.01) of developing relapse (9 of 18) than patients with lesser or no mediastinal disease (5 of 93). Of the 18 patients with large mediastinal disease, six relapsed in the mediastinum and two in the lung. There continue to be no pelvic extensions in the entire group. There is a 92% relapse-free and 97% overall survival in the 93 patients without extensive mediastinal disease. We continue to recommend mantle and para-aortic--splenic pedicle irradiation for these patients. In view of the large number of relapses in patients with extensive mediastinal disease, we are now treating this subgroup of patients with MOPP chemotherapy in addition to mantle and para-aortic irradiation.
Cancer 1978 Sep
PMID:The significance of mediastinal involvement in early stage Hodgkin's disease. 69 7

A case of nodulat sclerosing Hodgkin's disease in an elderly woman is presented. Following radiotherapy, widespread lymphomatous skin lesions developed anatomically unrelated to her nodal disease. These lesions have been controlled, but not eliminated by chemotherapy. Cutaneous manifestations of Hodgkin's disease are discussed including the possible pathologic mechanism in the present case. Skin involvement by Hodgkin's disease may follow a relatively benign course, provided disease elsewhere is treated appropriately.
Cancer 1978 Sep
PMID:Cutaneous Hodgkin's disease: indolent course and control with chemotherapy. 69 12

This case demonstrates that, as part of a favourable response to therapy, the "ivory" vertebrae of Hodgkin's disease can revert to a normal radiographic appearance.
Pediatr Radiol 1978 Sep 26
PMID:Resolution of Hodgkin's induced ivory vertebrae. 71 32

The risk of Hodgkin's disease (HD) in young adults is correlated to height. This association indicates an etiologic factor acting during growth. Our aim was to evaluate the importance of growth pattern as a risk factor in HD. The register of records from the school health service of the Copenhagen Council was scrutinized in order to find Danes with HD born between 1930 and 1950. Whenever possible, three matched controls (comparable in respect to socio-economic status) were selected from the register for each case. The material consisted of 63 cases and 183 controls. Information regarding height, weight and birth weight was obtained from the school health records. The patients were taller than controls at 8, 10, 12 and 14 years of age. The birth weight was available in 33 cases and 99 controls, and was higher in the former (median 3.50 kg) than in the latter (median 3.30 kg) (P less than 0.01). Our findings suggest the existence of either a risk factor associated with rapid growth or a protective factor connected with slow growth, effective even before birth.
Scand J Haematol 1978 Sep
PMID:Pre-morbid factors in Hodgkin's disease. I. Birth weight and growth pattern from 8 to 14 years of age. 71 77

Resort to laparotomy for the staging of Hodgkin's disease has been controversial because of its questionable advantage over nonsurgical staging methods. The recent concern over splenectomy and subsequent overwhelming infection has added to this debate. The author reviews experience with Hodgkin's disease in 34 patients whose ages ranged from 6 to 18 years. Seventeen patients underwent staging laparotomy after their disease had been staged by standard nonoperative methods; the duration of follow-up was from 2 to 7 years. In 7 of these 17 patients the stage of their disease was changed as a result of the laparotomy findings. Complications have been late septicemia resulting in death in one patient and subacute bowel obstruction not requiring reoperation in two patients. In the author's opinion staging laparotomy in children with Hodgkin's disease is a valuable means of deciding on their subsequent therapy.
Can J Surg 1978 Sep
PMID:Staging laparotomy for Hodgkin's disease in children. 71 63

The clinical and histopathologic findings in 25 cases of malignant lymphoma of the skin other than mycosis fungoides were reviewed. All patients had skin lesions as a primary manifestation of the disorder, and none had histopathologic evidence of extracutaneous involvement at the time of skin biopsy. The majority of patients had solitary nodules involving the skin of the head and neck region. Twenty-two of the skin biopsy specimens were interpreted as lymphocytic lymphoma, well or poorly differentiated, nodular or diffuse. Only three cases of histiocytic lymphoma (reticulum cell sarcoma) were encountered, and there were no cases of Hodgkin's disease of the skin. Twenty-two patients (88%) subsequently developed extracutaneous lymphoma: the interval from the occurrence of apparently localized skin lesions to involvement of lymph nodes and/or viscera ranged from 6 months of 5 years (mean duration of 21 months). Sixteen patients (64%) died of disseminated lymphoma, with survivals that ranged from 8 months to 12 years (mean survival of 3.7 years). Only three patients survived without disease for greater than 1 year. There was no definite relationship between either the histologic subtype of the tumor or the mode of therapy and prognosis. The patholoic findings indicate that a definite diagnosis of malignant lymphoma can be made by skin biopsy in patients with disease apparently confimed to the skin. Careful, detailed examination of the skin biopsy specimen provides a basis for distinguishing malignant lymphoma from cutaneous lymphoid hyperplasia. The clinical findings and survival data support the conclusion that malignant lymphoma with skin lesions as a primary manifestation almost invariably disseminates to extracutaneous organs and usually has a fatal outcome.
Cancer 1976 Sep
PMID:Malignant lymphoma of the skin: a clinicopathologic study of lymphoma other than mycosis fungoides. 78 88

The cellular change (phenotypic) leading to leukemia may involve a disorder of leukocyte maturation, but the etiologic molecular change (genotypic) remains unknown. We present evidence here that human leukemic cells contain type-C viral information and consider the possible significance of this observation in the context of a working hypothesis. We reexamine reticuloendothelial neoplasms in the light of newer immunologic, cytochemical, and ultrastructural methods for identifying cells of the T-lymphocytic, B-lymphocytic, and monocyte-macrophage systems. Use of these methods has led to a challenging concept of malignant lymphomas as neoplasms of various anatomic and functional compartments of the immune system. Functional studies, although still in their inception, have already provided provocative clues in the etiology and pathophysiology of these disorders. Advances in laboratory research have been paralled by dramatic changes in clinical oncology, as evidenced by trends in the treatment of acute lymphocytic leukemia, acute myelogenous leukemia, Hodgkin's disease, and diffuse histocyte lymphoma.
Ann Intern Med 1976 Sep
PMID:Current concepts of leukemia and lymphoma: etiology, pathogenesis, and therapy. 78 94

Peripheral blood spontaneous rosette forming T cells (RFC) were studied in 40 Hodgkin's Disease (HD) and 20 lymphosarcoma (LS) patients, classified according to the histological type and spread of disease and to their age, treatment, clinical condition and evolution. LS patients had near normal RFC values; in HD, the lowest values of RFC corresponded to the most severe histological picture. In all patients, differences could be seen according to the spread of the disease and the clinical condition, but none in relation with treatment nor with the clinical evolution in a one year period after the test. While in controls and LS patients, RFC were higher in younger than older subjects, in HD, values were higher after 50 years of age. The usefulness of RFC test in the evaluation of lymphoma patients is discussed.
Biomedicine 1976 Sep 30
PMID:Rosette forming T-cells in human lymphomas: relationship with age and clinical parameters. 79 47

Between 1970 and 1974 seventy patients suffering from Hodgkin's disease were admitted and treated in University College Hospital (UCH), Ibadan, out of which fifty (71.4%) had well documented chemotherapy. Standard combination chemotherapy of COPP/MOPP i.e. cyclophosphamide or mustine hydrochloride, oncovin, procarbazine and prednisolone was used on nineteen cases. Of these, twelve (63.2%) achieved complete remission. The longest survival to date is 4 years. Two patients (4%) had surgical excision of the affected lymph node and are alive and disease-free after 4 years of this treatment. They have had no maintenance therapy. The two patients (4%) in whom surgical removal of glands was followed by combination chemotherapy are also alive, well and disease free. Four patients had single agent therapy (Endozan) and died soon after starting treatment. One patient died shortly after diagnosis before therapy was instituted. Of the group treated with MOPP or COPP, all the patients were clinically stage IV and sixteen of the nineteen (84.5%) had histological mixed cellularity type of Hodgkin's disease. We confirm that combination chemotherapy gives very good tumour response and longest survival to patients with Stage IV disease. The main problems encountered during the period were the difficulty and the irregularities of supply of the chemotherapeutic agents. Better results can be obtained if these problems and that of high default rate can be solved.
Afr J Med Med Sci 1976 Sep
PMID:The therapy of Hodgkin's disease in Nigeria: a five year study. 82 30


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