Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of the investigation was to study the effect of lithium carbonate on the time-course of changes in neutrophil leukocytes of the peripheral blood. Sixty-nine patients afflicted with Hodgkin's disease were entered into the study. Greater preservation of the content of neutrophil leukocytes was attained with the use of lithium carbonate coupled with radiation therapy. At the same time administration of lithium carbonate in the interval between the stages of anticancer treatment brought about an increase in the neutrophil count.
 ...
PMID:[Correction of neutropenia with lithium carbonate during the radiation treatment of lymphogranulomatosis patients]. 309 61

Effects of lithium carbonate on peripheral white blood cell and granulocyte counts were investigated in children treated for acute lymphoblastic leukaemia and non-Hodgkin malignant lymphoma. Li2CO3 given orally for two weeks in a single daily dose of 700 mg/m2 caused a significant and lasting increase in the peripheral WBC and granulocyte counts and increased the granulocyte ratio during induction of remission and maintenance cytotoxic therapy. Haematologic actions and the long-term effect of lithium carbonate are discussed.
 ...
PMID:Effect of lithium carbonate on the peripheral leukocyte count in children suffering from haematological malignancies. 641 73

A study was made of the effect of lithium carbonate on the blood leukocyte count, absolute neutrophil and monocyte counts in 32 patients with neutropenia caused by the use of a specific treatment for lymphogranulomatosis (LGM), malignant lymphomas and multiple myeloma (MM), and in 5 patients with hypoplastic anemia (HA). Administration of lithium carbonate led to a significant increase in the total leukocyte and neutrophil counts in patients with LGM, malignant lymphomas and MM but not in patients with HA. The rise of the neutrophil count detected before (after 3 days) suggests that lithium may exert a direct stimulant action on relatively mature myeloid cells (promyelocytes and even myelocytes) but not on the undifferentiated colony-forming cells. The exponential dependence was found between an increase in the neutrophil count and duration of lithium intake, which permits forecasting the expected rise in the counts of these cells.
 ...
PMID:[Stimulating effect of lithium carbonate on neutropoiesis in iatrogenic neutropenia]. 643 1

A general mathematical version of the cell model of a leaky epithelium for the NaCl absorption is presented, analysed and integrated numerically. The model consists in the adequate differential equations that describe the rate of change of the intracellular ion concentrations and are expressed in strict accordance with the law of mass conservation. The model includes many state variables representing ion concentrations, the cell volume, and membrane potentials. Ion movements are described by the Michaelis-Menten kinetics or by the constant field flux equation (Goldman-Hodgkin-Katz). In this paper, we model the intracellular ion concentrations, change in the cell volume, the transmembrane flux and membrane potentials of intestinal epithelium of both fresh water and sea water fish, and generate several simulations (in both the steady state and the transient state analysis) that appear to accord with prior experimental data in this area. For the ion movements of the sea water fish intestine, there were included a Na+/K+ pump, a K(+)-Cl- symport system, the K+ and Cl- channels in the basolateral membrane, whereas a Na(+)-K(+)-2Cl- cotransporter for NaCl absorption and K+ channels are located in the apical membrane. In the fresh water fish intestinal cells, the NaCl absorption is performed by two coupled antiporters Na+/H+ and Cl-/HCO3- presumably responsible for the intracellular pH regulation. In this type of cells, Na+ and K+ channels are located within the apical membrane, whereas Cl- channels are located within the basolateral membrane. The osmotically induced water transport across the apical and basolateral membranes has been taken into account as well. The simulations plot the steady state values for membrane potential difference, short-circuit current and intracellular ionic concentrations using the magnitude of the transmembrane flux through the Na+/K+ pump and Na(+)-K(+)-2Cl- cotransporter, or the basolateral Cl- permeability as dependent variables. The model behaves appropriately with regard to several experimental studies regarding the hyperpolarization (sea water fish intestine) and depolarization (fresh water fish intestine) of the apical membrane potential and inhibition of the short-circuit flux with reduced NaCl absorption. The model is also used to make several analytical predictions regarding the response of the membrane potential and ionic concentrations to variations in the basolateral Cl- flux. Furthermore, maintaining conservation of both mass and electroneutrality and taking into account the osmolar forces is an important advantage, because it allows a rigorous analysis of the relationship between membrane potential difference, volume and flux. The model can be used in the analysis and planning of the experiments and is capable of predicting the instantaneous values of ionic fluxes and intracellular concentrations and of cell volume.
 ...
PMID:Characteristics of ionic transport processes in fish intestinal epithelial cells. 954 3

This is a rare case report of Hashimoto's thyroiditis in a patient with MALT thyroid lymphomas. The patient presented with an enlarged neck mass over the past 10 years and had rapidly enlarged neck mass with compressive symptoms for about 2 months. Examination by an endocrinologist found that the size of the thyroid gland was 120 gm with firm consistency and with no tenderness. She had clinical hypothyroidism and no abnormality of neither lymphadenopathy nor any masses. She was diagnosed with Hashimoto's thyroiditis because her thyroids function lest showed primary hypothyroidism [(FT4 = 0.76 ng/dl (0.93-1.71), FT3 = 1.76 pg/ml (1.8-4.6), TSH = 8.24 mIU/L (0.27-4.21)] with antimicrosomal antibody positive titers (> 1:409,600): Diagnosis of primary thyroid lymphoma was diagnosed by FNA and total thyroidectomy was performed. About 1 day after total thyroidectomy, she developed clinical hypocalcemia and the laboratory showed that calcium was = 6.2 ng/dl (8.5-10.1), phosphorus = 6.4 mg/dl (2.5-4.9). After 10% calcium gluconate replacement, her hypocalcemic symptoms didn't appear and she received oral replacement of calcium carbonate and vitamin D before discharge. During OPD follow up, her pathological report from Maha Chakri Sirinthorn Medical Center was a diagnosis of Non Hodgkin's lymphoma, low grade and the latter 1 week immunohistochemically staining of tumor markers indicated B-cell type (CD20) with MALT (AE1/AE3) lymphoma. Staging of the disease was stage IE and she received one course of CHOP (Cyclophosphamide, doxorubicin, vincristin and prednisolone). After one course of CHOP regimen, she was healthy and the hematologist ordered two courses of CHOP and external radiation.
 ...
PMID:Hashimoto's thyroiditis in a patient with non-Hodgkin's thyroid lymphoma of B cell type and originated from mucosa-associated lymphoid tissue (MALT): A case report. 1685 37