Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Malignant non-Hodgkin's lymphomas are rare in the absence of human immunodeficiency virus infection and it is exceptional for a cardiac site to be the prominent feature. In our case, the malignant lymphoma was revealed by pericardial effusion in a context of alteration of the general state. Echocardiography revealed a heterogeneous mass in the right atrium and an abundant circumferential pericardial effusion. Thoracic computed tomography allowed local staging and magnetic resonance imaging (MRI) allowed a better definition, than CT scan, of the extension of the tumour into the various cardiac structures. The histological diagnosis was established on biopsy of a mediastinal lymph node. The patient died 7 months after the diagnosis, despite chemotherapy. The authors emphasize the contribution of echocardiography in the diagnosis of cardiac tumours, computed tomography in local staging, and MRI in the analysis of the various cardiac structures.
Ann Cardiol Angeiol (Paris) 1995 Sep
PMID:[Malignant non-Hodgkin lymphoma of cardiac localization. Apropos of a case]. 856 38

Carotid sinus syndrome (SSC) is quite rarely associated with malignancy of the head and neck. We report a case of mixed type of SSC coupled to a left parapharyngeal centroblastic polymorphic non-Hodgkin lymphoma with high degree of histological malignancy. Syncope was the starting symptom and diagnosis, suspected on the ground of objective local signs, was settled by neck CT. Histological identification was performed after the tumor was surgically removed. Paralysis of left vocal cord and left cervical sympathetic nerve resulted associated with disappearance of spontaneous hypotensive events. The complex diagnostic program, often borne by such patients, stimulates to a critical review.
G Ital Cardiol 1996 Jun
PMID:[Carotid sinus syndrome associated with a left parapharyngeal non-Hodgkin's lymphoma]. 880 89

Computed tomography is currently the reference examination in the investigation of mediastinal tumours. We report a case of pericardial tumour revealed by transoesophageal echocardiography. This investigation immediately defined the limits of this mass and its relations with cardiac cavities and large vessels and suggested the main features of its tissue structure. However, the aetiological diagnosis is still based on CT-guided needle biopsy or investigation by mediastinoscopy or thoracotomy. Our case consisted of a non-Hodgkin lymphoma. Transoesophageal echocardiography is a non-irradiating technique, which can be performed at the patient's bed and which allows a precise assessment of the pericardial regions, especially the right pericardial regions.
Ann Cardiol Angeiol (Paris) 1996 Nov
PMID:[Transesophageal cardiac echography and paracardiac tumor masses. Apropos of a case]. 903 7

We report two patients with AIDS and non-Hodgkin lymphoma evolving myocardium. Clinical findings were nonspecific, but rapid progression and cardiac dysfunction developed. An echocardiogram showed restrictive pericarditis in both cases. One of them showed mitral insufficiency because of an infiltrated and trapped posterior mitral valve.
Rev Esp Cardiol 1997 Mar
PMID:[Non-Hodgkin's lymphoma with heart disease in patients with AIDS: clinical and echocardiographic aspects]. 913 81

As the number of adults surviving radiation therapy for Hodgkin's disease increases, the long-term clinical sequelae of such treatment is becoming increasingly more evident. Mediastinal radiation has been linked to acute and chronic pericarditis (with or without pleural effusion), coronary artery disease, myocardial fibrosis, valvular dysfunction and arrhythmias. The AA describe a case of a young patient with evidence of significant valvular disease following mediastinal irradiation, and review the radiation-induced cardiotoxicity, discussing aspects concerned with pathophysiology, diagnosis and therapy.
Rev Port Cardiol
PMID:[Heart disease induced by mediastinal radiotherapy in Hodgkin's disease: report of a clinical case]. 943 9

Inactivation is a widespread property of voltage-gated ion channels. Recent molecular biological advances in the potassium channel field have elucidated two mechanistically distinct types of inactivation, N-type and C-type. Both of these mechanisms are partially coupled to activation and are usually voltage insensitive once activation is complete. This study compared the effects of a hypothetical open channel blocker on macroscopic currents by using two different models of the same cardiac transient outward current channel. Model 1 is a Hodgkin-Huxley-like model in which inactivation is an independent voltage-sensitive process. Model 2 is a model in which inactivation is voltage insensitive but is partially coupled to activation. Both models have been shown to reproduce closely the experimentally observed current. However, when modelling open channel block, the two models can differ substantially in their equilibrium degree of drug binding. This difference in equilibrium can make substantial changes in the rate of current recovery in subsequent depolarizations. It is shown that, for a rapid series of depolarizations, the time course of development of block and the degree of steady state block can differ substantially between the two models. In conclusion, molecular mechanisms of inactivation must be taken into account when modelling conformation-specific drug binding and use dependence.
Can J Cardiol 1998 Jan
PMID:Models of potassium channel inactivation: implications for open channel block. 948 82

A 43-year-old woman with no risk factors received mediastinal radiotherapy of 35 Grays at the age of 23 years for Hodgkin's disease, followed by cure of the neoplastic disease. Twenty years later, following a threatened infarction syndrome, coronary angiography revealed ostial stenosis of the left coronary trunk. The course was rapidly unfavourable immediately following the examination.
Ann Cardiol Angeiol (Paris) 1998 Dec
PMID:[Ostial stenosis of the common trunk of the left coronary artery 20 years after mediastinal irradiation]. 992 51

While radiation therapy has been known to cause myocardial and pericardial damage, its role in accentuating coronary artery disease in the absence of traditional cardiovascular risk factors has been controversial. As younger patients with treatable cancers are being treated with mediastinal radiation, coronary artery disease as a cause for severe chest pain should be entertained as a possible diagnosis. We describe a 25-year-old male who presented with an inferior wall myocardial infarction 6 years after receiving mediastinal radiation and chemotherapy for Hodgkin's disease. He was subsequently treated by directional atherectomy to a 95% lesion in the right coronary artery. Histological examination of the atherectomy specimen revealed evidence of radiation-induced endothelial damage that had resulted in plaque formation and subsequent ischemia. Possible mechanisms for radiation-induced coronary artery disease and treatment options are discussed.
J Interv Cardiol 1995 Aug
PMID:Directional coronary atherectomy for the diagnosis and treatment of radiation-induced coronary artery stenosis. 1017 46

Previous radiotherapy to the thorax is a risk factor for coronary artery disease. Patients with radiation-induced atherosclerosis tend to be young and frequently have lesions involving the coronary ostia and left anterior descending artery. Bypass is often the most suitable method of revascularization, and given the young age of the patient, arterial conduits would be considered superior to vein grafts. However, the internal thoracic arteries can lie within the radiation field and may not be free of atherosclerosis. A 40-year-old man who required coronary artery bypass grafting for multivessel coronary artery disease 11 years following radiotherapy for Hodgkin's lymphoma is reported. Preoperative angiography showed that the right internal thoracic artery had significant atherosclerosis and was unsuitable as a conduit.
Can J Cardiol 1999 May
PMID:Mediastinal irradiation: A risk factor for atherosclerosis of the internal thoracic arteries. 1035 Jun 71

We present a patient with acute retrosternal pain and dyspnoea. Clinical examination revealed a woman in shock with a loud holosystolic murmur and congested jugular veins. Echocardiography showed severe mitral insufficiency. At transoesophageal echocardiography a large mass was seen in the right atrium. The differential diagnosis was a thrombus or an intracardiac tumour. Subsequent histology revealed a non-Hodgkin lymphoma in the right atrium, the wall of the left atrium extending to the mitral valve and further location in the pelvis and duodenum. The discussion incorporates a brief overview of the literature.
Acta Cardiol 2001 Apr
PMID:An unusual case of biventricular cardiac failure. 1135 25


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