Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019829 (
Hodgkin's disease
)
30,247
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Acquired angioedema due to C1-INH deficiency (C1-INH-
AAE
) can occur when there are acquired (not inherited) deficiencies of C1-INH. A quantitative or functional C1-INH deficiency with negative family history and low C1q is diagnostic of C1-INH-
AAE
. The most common conditions associated with C1-INH-
AAE
are autoimmunity and B-cell lymphoproliferative disorders. A diagnosis of C1-INH-
AAE
can precede a diagnosis of lymphoproliferative disease and confers an increased risk for developing non-
Hodgkin lymphoma
. Treatment focuses on symptom control with therapies that regulate bradykinin activity (C1-INH concentrate, icatibant, ecallantide, tranexamic acid, androgens) and treatment of any underlying conditions.
...
PMID:Acquired C1 Inhibitor Deficiency. 2868 5
