Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Judging from the spontaneous NBT reduction, the indices of phagocytosis and NBT, there is a moderate, but statistically significant diminution of these parameters in leukaemia and malignant lymphoma including plasmocytoma. Moreover, further diminutions could be identified during the acute stage of the disease (first diagnosis or recidive) in acute leukaemia and lymphogranulomatosis, but not for chronic myeloic leukaemia.
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PMID:[Phagocytic granulocyte function in hemoblastoses]. 7 20

The NBT-test was performed in 54 patients with Hodgkin and non-Hodgkin lymphoma showing no bacterial infection exept for one case. 18 patients presented, at onset of the disease, a number of neutrophilic NBT-reducing granulocytes at pathological levels (greater than 12%). In order to evaluate the influence of cytostatic drugs on NBT-test serial blood samples were taken during polychemotherapy in 17 patients with lymphoma. In our experience, cytostatics (COPP) do not necessarily lessen NBT-reducing activity of granulocytes. The results suggest that the NBT in malignant lymphomas could not be used as an indication of bacterial infection.
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PMID:Evaluation of non-stimulated nitroblue-tetrazolium test in patients with malignant lymphomas. 72 24

Human peripheral blood monocytes were tested for various functions. It was found that 63--70% of monocytes from 12 normal subjects phagocytized either Staphylococcus epidermidis or latex particles; 28% of Staphylococcus organisms exposed to cells were phagocytized in 1 h and 67% were killed within 2 h; 59% of phagocytizing cells reduced NBT; 77% of endocytosed rabbit gammaglobulin was catabolized in 18 h. In Hodgkin's disease, sarcoidosis and severe pulmonary tuberculosis, phagocytic and bactericidal capacity was decreased in one third to two thirds of cases, while catabolism of gammaglobulin was reduced less often and metabolism was practically unmodified. By contrast, phagocytic and bactericidal capacity were practically normal in the common variable form of agammaglobulinemia, while gammaglobulin was catabolized at a low level in all cases. There was no relationship between the functional disorders of monocytes and alterations of lymphocyte stimulation. These results indicate that mononuclear phagocytes may have intrinsic alterations of functions which can result in deficient defense mechanisms and/or immune response.
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PMID:The functions of human monocytes in normal subjects and in disorders associated with immune deficiency. 88 35

The NBT reduction test and determination of alkaline phosphatase activity in the peripheral blood granulocytes (FAG) were done in 94 subjects including 30 blood donors donating blood for the first time and 64 cases of various haematological syndromes. Raised proportion of formazan granulocytes was found in patients with pancytopenia, acute myeloid leukaemia, chronic myeloid leukaemia during blastic exacerbation, Hodgkin's disease during exacerbation and lymphosarcoma. These results correlated with increased FAG activity. Lower proportions of formazan granulocytes capable of spontaneous reduction of NBT were found in patients with chronic myeloid leukaemia, in immunohaemolytic anaemias and in plasmocytoma. Of all the above syndromes only in chronic myeloid leukaemia impaired ability of formazan cell formation parallelled decreased FAG activity. In the remaining syndromes FAG activity in the granulocytes was normal or raised. In the remissions of Hodgkin's disease a fall was observed in the proportion of formazan granulocytes to values of FAG. In chronic myeloid leukaemia the proportion of formazan cells showed considerable fluctuations and no correlation was observed between the proportion of formazan cells and FAG activity.
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PMID:[Spontaneous nitroblue terazolium reduction test (NBT) by peripheral blood granulocytes in healthy subjects and in some hematologic syndromes]. 105 43

In sixty children with acute lymphoblastic leukemia, Hodgkin's disease or lymphosarcoma 121 determinations of the NBT test were performed in various periods of disease. All the children studied were free of infectious complications. In acute lymphoblastic leukemia the NBT test values were low during relapses of the disease and increased above normal values in the period of remission. In the group with Hodgkin's disease an increase of the NBT test values was always associated with the active stage of the disease. No significant differences between the relapse and the remission period were found in children with lymphosarcoma.
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PMID:Nitroblue tetrazolium (NBT) test in children with acute lymphoblastic leukemia or malignant lymphomas. 107 76

The cell lines HDLM-2 and L-428 were established from the pleural effusions of two patients with Hodgkin's disease. We studied and compared phenotypic characteristics of HDLM-2 and L-428 cells before and during induction of differentiation with 12-O-tetradecanoylphorbol 13-acetate (TPA) using a number of parameters. TPA-treated HDLM-2 and L-428 cultures did not show adhesion to plastic surface or aggregation of cells; the cells did not develop pseudopodia and were not phagocytic. Only a slight increase in the percentage of NBT-positive cells was observed for L-428 cells. TPA led to a cessation of cell proliferation and to a dose-dependent decrease in the number of viable cells in both cell lines. In HDLM-2 and L-428, treatment with TPA induced distinct morphological changes indicative of a partial differentiation along the myeloid cell lineage. In addition, the production and expellation of benzidine-positive, unnucleated particles were observed in HDLM-2 and L-428 cells. The induced isoenzyme profiles of carboxylic esterase and acid phosphatase resembled those found in myelomonocytic leukemia cell lines. Both cell lines were negative for immunological markers of the T- and B-cell lineages, but reacted with several markers associated with the myelomonocytic cell lineages. HDLM-2 cells produced a factor which could induce differentiation in 12 leukemia cell lines. The overall results suggest that Hodgkin and Sternberg-Reed cells constitute a unique cell type and might be derived from cells of the myelomonocytic cell lineage.
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PMID:Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of morphology, immunological and isoenzyme profiles. 371 48