Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lennert's classification of non-Hodgkin-lymphomas is introduced including a brief explanation of certain ENT aspects. The problems of the prognosis, therapy and a staging have an increasing interest for the ENT physician. Particular clinical pictures of non-Hodgkin's lymphomas in the head and neck region are described.
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PMID:[Classification and evaluation of non-Hodgkin lymphomas and their manifestations in the ENT area]. 662 64

112 cases of Hodgkin's disease diagnosed between 1967 and 1976 at the Institute of Pathology and the Department of ENT, Medical Academy of Erfurt, GDR, were reclassified according to the Rye classification. Age and sex distribution as well as frequency and survival are presented. The most frequency subtype is "mixed cellularity" (43.8%) followed by "nodular sclerosis" (40.2%). The age distribution of all cases shows 3 peaks with only small differences between the subtypes. The cases are distributed among 71 males and 41 females. The most frequent subtype in males is "mixed cellularity" (50.7%) whereas in females it is "nodular sclerosis" (61.0%) The survival of cases with "lymphocyte predominance" and "nodular sclerosis" is significantly better than that of case with "mixed cellularity" and "lymphocyte depletion".
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PMID:[Hodgkin's lymphoma in the biopsy material. A retrospective analysis (author's transl)]. 709 May 91

The study objective was to determine if suppression of ovarian function by oral contraceptives (OCs) would provide protection against ovarian cell death secondary to chemotherapy. By means of menstrual history, serum gonadotropin levels, and ovarian biopsy, ovarian function was evaluated in 6 young women with untreated Hodgkin's disease. The women ranged in age from 18 to 31 years at onset of treatment. Each woman was given a standard 6 cycles of MVPP therapy (nitrogen mustard, vinblastine, procarbazine, and prednisone). At the time of initiation of MVPP therapy, they were placed on the combination OCs Norlestrin or Ovran on the usual schedule for birth control. 6-12 weeks after the last cycle, 3 women were biopsied and the menstrual history was repeated in all cases. This followup was repeated at intervals of 4-12 months, the most recent in April 1981, range 20-29 months, median 26 months. 5 ovarian biopsies obtained prior to therapy contained 18-55 primordial and primary follicles. Posttherapy ovarian biopsies were performed on 3 of the 6 women who had been treated with OC while they were receiving the 6 cycles of MVPP therapy. The ovary specimens revealed 22, 1000, and 22 primordial and primary follicles per section. Normal menses were established in the 5 women who discontinued OCs at the end of MVPP therapy, and 1 of them is currently pregnant. The pregnancy and the regular menses in the 3 women not on hormonal agents up to 2 years after stopping MVPP therapy encourages the belief that these women will not experience premature menopause in a few years' time. Particularly hopeful is the normal ovarian function of the 30-year-old woman, the woman who was at greatest risk for chemotherapy-induced ovarian failure.
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PMID:Protection of ovarian function by oral contraceptives in women receiving chemotherapy for Hodgkin's disease. 727 13

The ENT manifestations of HIV infection are well known and the findings in AIDS patients have been described, nevertheless there are no reports of the frequency of head and neck involvement during the various stages of the disease. From 1987 to 1991, 210 HIV positive patients had ENT evaluation without symptoms-related selection. The majority of them were men and intravenous drug users. The frequency of enlarged neck nodes, neck mass, nasopharyngeal lymphatic tissue hypertrophy, extranodal localization of non-Hodgkin's lymphomas, Kaposi's sarcoma, oral hairy leukoplakia, candidiasis and other less common findings is reported, in relation to the stage of the disease. Overall 84 per cent of the observed patients had head and neck manifestations. An ENT evaluation in every HIV infected patient is suggested.
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PMID:Head and neck manifestations during HIV infection. 849 46

The otorhinolaryngological signs of AIDS are reviewed (both analysis and synthesis) following the chronological order of the literature. The earliest clinical pictures, their frequency and time of onset, are described by the authors studied. In 1986 the ENT signs of this disease were well known, and in our region the same multiple, polyfacetic aspects are seen. Personal experience of this is described, emphasizing how seldom the diagnosis has been made, except early on. Usually the cases seen and diagnosed by the Department of Infectious Diseases were referred for specialist opinion. The commonest findings were, amongst the opportunist infections: oropharyngeal and oesophageal candidiasis, and tuberculous adenopathies. Classical ENT pathology was represented by sinusitis and to a lesser extent by otitis and tonsillitis. The tumours seen were non-Hodgkin lymphomas, but no Hodgkin's or Burkitt's lymphomas. There was an unusual case of 'high grade centroblastic lymphoma', localized to the tonsil and presenting as necrotic tonsillitis and peritonsillar abscess. Recently a patient with a large pharyngeal tumour (still being investigated) has been provisionally diagnosed as having a cavernous angioma. Both these patients were diagnosed by us, since we saw the first sign of the disease. We have seen few Kaposi's sarcomas, since cutaneous and oral lesions are not usually referred to us.
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PMID:[AIDS manifestations in otorhinolaryngology]. 906 87

We report two patients with Hodgkin's disease on chemotherapy, one with vincristine, the other with vinblastine, who were referred to the ENT department with a vocal fold palsy. These drugs are commonly used in the treatment of haematological malignancies, and head and neck sarcomas. Examination showed a unilateral immobile fold. No causative local pathology was identified, and they were otherwise thought to be achieving remission, but the development of a fold palsy suggested a poor response to treatment. One patient's palsy resolved following completion of chemotherapy, but the other patient's persists, despite an otherwise good response to the treatment. The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial mononeuropathies are a rare side-effect. A total of 27 previous cases of vocal fold palsy have been reported with the use of the vinca alkaloids, and such a lesion should not be assumed to be due to advancing lymphoma.
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PMID:Vocal fold palsy following vinca alkaloid treatment. 974 83

In three new approved indications (non Hodgkin's lymphoma, Hodgkin's lymphoma and acute lymphoblastic leukaemia) and in three previously existing indications (ovarian cancer, soft tissue sarcomas and osteogenic sarcomas), non comparative trials show that ifosfamide can induce tumour regression in patients who relapse after a first course of chemotherapy (sometimes containing cyclophosphamide). But clinical assessment has not yet formally demonstrated that this leads to a significant increase in survival time and/or quality of life, mainly because of toxicity. In cervical cancer, a new indication, a comparative trial shows higher tumour response rates with the ifosfamide + cisplatin combination than with cisplatin alone. However, the greater toxicity of the combination and the lack of any increase in survival must both be taken into account. In breast cancer and lung cancer comparative trials show no difference in efficacy between cyclophosphamide and ifosfamide, while toxicity may be worse with ifosfamide. Ifosfamide has no specific value in these approved indications. The same applied to ENT cancer, against which ifosfamide seems to have little activity.
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PMID:Ifosfamide: new idications-new dose strength. Limited evidence of effectiveness. 1018 82

CANCER AND HIV INFECTION: As the HIV epidemic advances, the spectrum of non-AIDS defining malignancy is expanding. Recent reports suggest an increased incidence of skin cancers, squamous cell carcinomas of the anus, and Hodgkin's disease in HIV-infected patients. Other neoplasms encountered in this setting include oral mucosa, head and neck carcinoma without evidence of increased incidence. PARTICULAR FEATURES: The natural history of lung, testicle and skin cancer (excepting Kaposi sarcoma) as well as ENT cancer appears to be modified in HIV-infected patients. The main problem raised by these tumors is confounding infection which may lead to late diagnosis or an error in tumor staging.
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PMID:[Cancer in patients infected with the human immunodeficiency virus. The unusual aspects]. 1032 41

The purpose of this study was to collect ENT signs observed during lymphomas. The study was conducted in the unit of ENT at the CHU of Treichville, during 15 month from december 1995 to march 1997. Ten cas of lymphomas was enrolled with 6 Hodgkin's lymphomas, 3 acute leukemia and 1 Hodgkin's lymphoma. The diagnosis was based on biopsy and myelogram. There is a wide spectrum and non specific clinical pictures. Pharynx is the common site particularly on the Waldeyer's ring. The disease is common among young people, low socio-economical status. Female are predominant. Most patients died before specific treatment because of the late diagnosis.
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PMID:[ORL manifestations in malignant hemopathies]. 1044 82

The authors presented 27 cases of primary extranodal non-Hodgkin's malignant lymphomas of the head and neck area in patients treated surgically in the ENT Department in the years 1996-2001. We observed tumors in the various areas: palatine tonsil, naso-pharynx, eye socket, paranasal sinuses, parapharyngeal space and lingual base. In the course of the diagnostic process we examined the patients carefully to be sure that the cancer had not disseminated. We used some imaging techniques such as: ultrasonography, CT and MRI. We also used the needle aspiration biopsy, as a additional examination. However the material was not significant in the most cases and we were unable to make a definitive diagnosis on the basis of this method alone. After prior examinations we performed the radical operations and removed the tumours. In each case the postoperative material was examined using immunohistochemical methods. Afterwards the pathomorphological diagnosis was made by the specialists. Next the patients were observed and treated in the Haematological Department and Radiotherapy Department. In all cases pathomorphological diagnosis were performed on the base of usage postoperative histochemical examinations. All treated patients were performed as diagnostic preoperative USG, CT, MRI and fine-needle biopsy aspiration exam. All patients for further treatment were observed at Haematological Department.
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PMID:[Histologic and clinical assessment of primary extranodal non-Hodgkin malignant lymphomas of the head and neck region]. 1531 83


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