Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019829 (Hodgkin's disease)
30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of Beau's lines secondary to combined chemotherapy for Hodgkin's disease is reported. These transverse nail depressions are interpreted as the result of a transient interruption of the nail matrix activity due to antimitotic drugs. Other causes of Beau's lines are reviewed.
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PMID:Chemotherapy-induced transverse ridging of the nails. 193 37

We describe a case of fever of unknown origin (FUO) of 9 months' duration in which the finding of regularly spaced multiple Beau's lines (the "ladder nail" sign) pointed to the possibility of a relapsing fever of the Pel-Ebstein variety and an underlying lymphoma. Subsequent investigation confirmed the association of the Beau's lines and fever, as well as the diagnosis of Hodgkin's disease as the cause of the FUO. In this setting, Beau's lines may provide an important diagnostic clue and should be carefully looked for on physical examination.
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PMID:Multiple Beau's lines in a patient with fever of unknown origin. 805 9