Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The head and neck region is - among the body regions - one of the most frequently affected one by malignant primaries in childhood and adolescence. The diagnosis of malignant lymphomas (Hodgkin's and non-Hodgkin's type) predominanted (55 cases) in the own case material of 94 patients. Besides, there were 21 tumors of mesenchymal origin, 11 neuroepithelial tumors and 5 cases of histiocytosis X. The first symptoms are often discret (painless swelling) and they represent one of the major problems in handling childhood tumors. An optimal therapy, which resulted in longterm cures in the majority of the own patients, is based on an intensive team-work of pediatricians and ENT-doctors. One of the important points for successful treatment is individualizing the intensity of each of the effectful modern therapeutic modalities.
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PMID:[Contribution to the diagnosis, therapy and prognosis of head and neck tumors in childhood and adolescence: experience with 94 own cases (author's transl)]. 12 28

Biopsy of the nasopharynx was perfomred in 45 patients with Hodgkin's disease as part of the pretherapeutic staging. Seven of the 45 (16%) had microscopic abnormalities in the nasopharynx compatible with Hodgkin's disease. Such abnormalities occurred even in the absence of local ENT-symptoms or signs, and they could not be predicted from the microscopic type of lymph node biopsy, stage of disease or general presentation. A generous biopsy of the nasopharynx is recommended to be included in the staging procedures in Hodgkin's disease.
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PMID:Biopsy of the nasopharynx as a staging procedure in Hodgkin's disease. 100 42

We report the results of immunological surveillance of 60 patients with advanced ENT, mammary and bronchopulmonary cancers or Hodgkin's disease, treated only by physical agents. These patients were explored by blastic stimulation testing before, during and after radiation therapy. The results confirm an immunodepressive effect of radiotherapy which increase as the irradiated areas increase, thus showing the importance of immunological surveillance of the cancer patients especially after irradiation. In effect the correlation existing between the importance of immunological repair after irradiation and a good short-term prognosis lead us to plan new radio-immunotherapeutic associations in the treatment of advanced cancers or cancers with a poor prognosis.
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PMID:[Influence of treatment with ionizing radiations on the immune response of cancer patients]. 122 18

For an optimum therapy of malignant lymphomas in the ENT region an extensive analysis of the interrelations of exact histological classification, clinical manifestation and prognosis is desirable. We therefore classified, according to various criteria, 57 patients (34 male, 23 female) aged between 17 and 88, in whom the first diagnosis of a malignant lymphoma was established at our department between 1970 and April 1989. Histologically, in 52 cases (91%) this concerned a non-Hodgkin lymphoma (NHL), in the other 5 cases Hodgkin's disease (HL). According to the "Kiel classification", 60% of the NHL displayed a high degree of malignancy, 36% a low one, while 4% could not be exactly classified histologically. Clinically (Ann Arbor classification), 27 patients with NHL were at stage I (with 21 at stage IE), 16 patients at stage II (with 14 at stage II E), and 9 patients at stage IV. The first manifestation was often extranodular (9 patients tonsil, 8 parotid gland, 8 base of tongue, 7 nasopharynx). A cervical lymph node enlargement was the first sign in 12 patients only. Four patients with NHL additionally developed a second malignancy (squamous cell carcinoma) of another localization. The 5-year survival rate was 81% at stage I, but there were no meaningful differences between stage II (51%) and stage IV (40%). Our study demonstrated that malignant lymphomas of the head and neck are primarily NHL which frequently affect an extranodular organ as a first manifestation. Moreover, malignant lymphomas in the ENT region seem to have a relatively good survival prognosis even in an advanced stage.
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PMID:[The clinical manifestations of histologically classified malignant lymphomas in the ENT area]. 228 27

Neoadjuvant chemotherapy can be used before radiotherapy to combat microscopic metastatic loci and to facilitate irradiation. Improvement in the survival time by impeding the dissemination of metastases seems to be real for breast cancer, but has not been observed to date in randomized studies of ENT cancers. Neoadjuvant chemotherapy in Hodgkin's disease has improved survival time and tolerance to irradiation, allowing a lowering of the total doses used and the volumes irradiated. In breast and ENT cancers, it has become possible, due to tumor regression, to replace mutilating treatments with more conservative ones consisting of radiotherapy alone, without increasing the risk of local relapse. Indeed, it is in this domain that neoadjuvant chemotherapy is the most useful. Two important conditions must be met for its successful application: a) a sufficiently effective regimen must be chosen, in order to prevent tumor growth prior to irradiation (which would aggravate the prognosis); and b) an accurate identification and localization of the tumor before undertaking any treatment so as to not detract from the effectiveness of the radiotherapy.
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PMID:[Radiotherapy with neoadjuvant chemotherapy]. 251 29

Sixty-three children with non Hodgkin's lymphoma involving the ENT zone (Waldeyer's ring) were treated between 1975 and 1985 at the Institut Gustave-Roussy. The tumors were localized in the cavum (32 cases), tonsils (16 cases), mandibles (9 cases) whereas 6 patients had more than one of these sites involved. At the time of diagnosis, 16 (25%) had neuro-meningeal involvement. Distribution, according to stages and histology was as follows: 4 stages I, 27 stages II, 12 stages III, 17 stages IV and 3 were unclassifiable. A Burkitt type of lymphoma was diagnosed in 37 (58%), a convoluted lymphoblastic type in 6 (10%) and 20 (32%) fell in a broad category of "other lymphoblastic variety" (32%). With regard to therapy, two consecutive time periods could be identified: from 1975 to 1980 all patients were given the same treatment and neuro-meningeal prophylaxis consisted of irradiation of the skull and intrathecal injections of methotrexate. Since 1981, the therapeutic regimen is designed according to the histo-immunological classification of the tumors and neuro-meningeal prophylaxis is carried out with the use of high dose methotrexate. With this new approach the survival rate has increased from 45 to 80% and the incidence of neuromeningeal relapses has decreased.
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PMID:[Clinical, anatomo-pathologic aspects and therapeutic results in 63 malignant ORL non-Hodgkin's lymphomas in children]. 260 11

The histological study of 36 cases of Non-Hodgkin Lymphomas beginning for the E.N.T. area has allowed us to show that the Non-Hodgkin Lymphoma Working Formulation made for the lymph nodes may be used to ENT Localization and give a reliable prognosis. Other elements like: sex, clinical staging, treatment have no significant value concerning the survival rate in our study. This study agrees with the previous studies about the predominance cases to the high power of malignancy of these lymphomas.
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PMID:[Retrospective study of the prognostic value of histological criteria in lymphoma of the ORL region]. 387 1

Malignant non-Hodgkin's lymphomas are a heterogeneous group of neoplasms with different natural histories and prognoses. Often the patient is first seen by the ENT-specialist with cervical lymphadenopathy as the first complaint. In Germany the histological Kiel-classification is most often used. This is based on the normal structures of the lymphatic tissue as the basis. Therapy is quite different for the various lymphomas depending on histology and stage of disease. Chemotherapy of varying intensity, radiotherapy, or both may be used. Prognosis is less favourable than in Hodgkin's disease but some subgroups have a chance of cure even in advanced stages and others run a natural course over several years without treatment.
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PMID:[Malignant non-Hodgkin lymphomas--a review]. 407 87

The details of 37 children presenting a malignant tumor in the ENT-region (period 1950-1983) are presented and discussed. The prevalence was higher in boys than in girls and the most common tumors were non-Hodgkin lymphoma (n = 14) and rhabdomyosarcoma (n = 13). The most common primary sites were the nasopharynx (9 cases), the paranasal sinuses (7 cases) and the soft tissue in the parotid region (7 cases). In 23 children the presence of a painless tumor was the first symptom, in 11 pain was predominant. Only a minority (5 children) presented a limited tumor; in 20 children there was a local extension of the tumor and in 10 children metastases were present at the first visit. The beneficial role of chemotherapy and the necessity of a good teamwork in the treatment of these children is outlined. Of the 37 children, 14, (38%) are surviving; of these 14 children, 12 are off therapy and cured. It is demonstrated that the prognosis improved considerably since the last 14 years.
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PMID:Malignant otolaryngological tumors in children. 651 33

Lennert's classification of non-Hodgkin-lymphomas is introduced including a brief explanation of certain ENT aspects. The problems of the prognosis, therapy and a staging have an increasing interest for the ENT physician. Particular clinical pictures of non-Hodgkin's lymphomas in the head and neck region are described.
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PMID:[Classification and evaluation of non-Hodgkin lymphomas and their manifestations in the ENT area]. 662 64


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