Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A report on a 74-year old woman with high-grade malignant non-Hodgkin lymphoma in clinical remission, who suddenly developed episodes of severe dyspnea and wheezing. Clinical and roentgenographic investigations including tomography of the trachea failed to demonstrate any lesion. Fiberoptic bronchoscopy revealed and endotracheal, polyp-like lymphoma 3 cm above the carina, which was immediately operated. Other sites of relapse (submandibular lymph-nodes) were found 2 weeks after the operation. Second-line chemotherapy (IMVP 16) was able to induce a second remission.
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PMID:Respiratory distress as primary symptom of relapse in a patient with non-Hodgkin lymphoma. 385 Jul 53

Although mediastinal involvement by Hodgkin's disease is frequent, the initial presentation of the lymphoma by an endobronchial lesion is rare. Therefore, the question of whether patients with Hodgkin's disease should undergo fibreoptic bronchoscopy as a staging procedure remains unresolved. In a series of 469 patients with newly diagnosed Hodgkin's disease during a 10 year period, we reviewed the clinical features of nine patients who presented with an endobronchial tumour. They were compared to 34 previously published cases. The major presenting symptoms were cough, wheezing and haemoptysis. Bulky mediastinum was seen in six cases. The three other patients presented respiratory symptoms evocative of endoluminal invasion. All but one of the patients received combined modality therapy, as currently accepted for patients with poor prognostic factors. The overall actuarial survival was 74% after 4 yrs of follow-up. A selective subgroup of patients with stage I-II supradiaphragmatic and endobronchial Hodgkin's disease may, thus, present without poor prognostic factors (but generally with respiratory symptoms), and might be undertreated if this localization is not recognized. We propose that these patients should undergo fibreoptic bronchoscopy.
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PMID:Endobronchial presentation of Hodgkin's disease: a report of nine cases and review of the literature. 782 96

Pulmonary function tests were performed in 78 patients who had been curatively treated for Hodgkin's disease with mantle field irradiation 10-18 years ago. Mean values of the total lung capacity (95.2%), vital capacity (VC) (95.9%), forced expiratory volume in 1 s (FEV1) (90.6%), and carbon monoxide diffusing capacity per unit alveolar volume (82.7%) showed significant deviations from the predicted normal values, standardised for age, sex, race and height. In a multiple regression analysis the normalised total dose of irradiation, the field of irradiation, and the interval since irradiation had independent negative effects on the test results. Patients reported more coughing, wheezing and dyspnoea on exertion in comparison with hospital-visitors. Their smoking habits and reported pulmonary disease were not different. It is concluded that small, but significant impairment of pulmonary function exists after a follow-up of 14 (2) years [mean (S.D.)]. The clinical impact of these findings seems, however, minimal. Further avoidance of pulmonary toxicity requires a careful quantitative study of the effects of the radiation dose and irradiated volume.
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PMID:Pulmonary morbidity 10-18 years after irradiation for Hodgkin's disease. 839 31

Primary pulmonary lymphomas (PPL) only constitute 4% of extra-nodal, non-Hodgkin lymphomas (NHL), less than 1% of NHL in general, and between 0.5% and 1% of malignant pulmonary neoplasms. Fifty-eight to 87% of cases of this extremely uncommon disease are low-grade B-cell lymphomas and 11%-19% are high-grade or large B-cell lymphomas. The prognosis for.high-grade or large B-cell lymphomas is worse than for low-grade lymphomas; respiratory and general symptoms are usually present. However asthmatic symptoms are not often found in their clinic. We report the case of a 49-year old woman with resistant asthma clinic in the form of wheezing, dyspnea and non-productive painless cough; associated with an irregular lobulated mass with air bronchograms in the lower lobe of the right lung. Histological diagnosis showed a pattern of high-grade B-cell lymphoma and all asthmatic symptoms disappeared following gross total resection of this lesion.
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PMID:Primary pulmonary lymphoma disguised as asthma. 1661 36

Two cases of primary pulmonary Hodgkin's lymphoma PPHL are presented, a male aged 21, and a female aged 32 years. Symptoms included non-productive cough, shortness of breath, low-grade fever, wheezing, and weight loss. Duration of illness varied between 6 weeks in the male patient to 7 months in the female patient. Both patients were given an empirical trial of antibiotics and anti-cough measures with no response. Radiological studies carried out after failure to respond to medical treatment, revealed the presence of pulmonary parenchymal masses in both patients. Cytology, bronchoscopic and transbronchial biopsies were not diagnostic, which led to opened wedge resections. Finally, the diagnosis of primary pulmonary Hodgkin's disease was reached after supportive immunohistochemical staining CD30 and CD15 both positive in RS cells. Both patients were regarded as stage I extranodal IE after exhaustive measures failed to demonstrate involvement of other body sites.
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PMID:Primary pulmonary Hodgkin's lymphoma. A report of 2 cases and review of the literature. 1753 Jan 15

Inaugural tracheobronchitis is a rare but known manifestation of Hodgkin's disease. Clinical signs are often misleading, retarding diagnosis and treatment. We report a case of Hodgkin's disease revealed by wheezing with minimal hemoptysis. Histology of the endoscopic biopsies demonstrated Hodgkin type infiltration of the trachea with mixed cellularity. The patient was given chemotherapy and mediastinal radiotherapy and achieved complete remission.
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PMID:[Tracheal involvement revealing Hodgkin's disease. A case report]. 1816 36

Primary tracheal non-Hodgkin lymphoma is an extremely rare entity without consensus management strategy. We present a case of primary tracheal lymphoplasmacytoid lymphoma masquerading as asthma with wheezing and progressive dyspnea. A patented nitinol mesh stent was implanted in the right lateral cervical region 3 weeks before tumor resection. After 5.5-cm-long segmental tracheal resection, a neotracheal tube was constructed with cervical myocutaneous flap sandwiched around the implanted mesh stent, which was then anastomosed with the residual of the patient's trachea. The patient has been well for 30 months.
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PMID:Two-stage tracheal reconstruction of primary tracheal non-Hodgkin lymphoma with nitinol mesh stent and cervical myocutaneous flap. 1829 Nov 44