Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary Hodgkin's disease in the bone is extremely rare. We report the case of a 41-year-old woman with Hodgkin's disease, who had complained of left coxalgia 17 months prior to nodal involvement becoming evident clinically. She received combination chemotherapy with doxorubicin, bleomycin, vincristine and dacarbazine as well as radiotherapy to the pelvic lesion. Although the lymphadenopathy responded well to this treatment, the bone lesion was never in remission. The large mass of the bone lesion and its pelvic origin may explain the poor response to the cytotoxic therapies this patient received. The 22 cases reviewed showed that: 1, bony pain was the most frequent initial symptom; 2, nodal disease appeared in their clinical course in most cases; 3, the bones most commonly involved were pelvis, femur or tibia, and spine.
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PMID:Coxalgia as the initial symptom in Hodgkin's disease: a case report. 939 Feb 17

Xanthoma of bone is a rare bone disorder characterized as a lytic lesion, often with cortical expansion or disruption. Because of its aggressive radiographic appearance, other primary bone tumors and metastatic lesions need to be ruled out. we present three cases of intraosseous xanthoma: one occurring as a pathologic fracture in the distal tibia, one discovered incidentally in the iliac crest in a patient with hip pain, and one discovered incidentally in the occipital bone of the skull in a child with widespread Hodgkin's lymphoma. All patients were treated with curettage of the lesions; craniectomy followed by cranioplasty for the occipital lesion, and curettage followed by internal fixation and bone grafting for the tibial lesion. The lesion in the iliac crest was treated with curettage and bone grafting. At the most recent follow-up (12, 15, and 24 months for patients with occipital, iliac crest, and tibial lesions, respectively), there was no evidence of local recurrence.
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PMID:Xanthoma of bone: a report of three cases and review of the literature. 1922 50

Initial extranodal osseous presentation of Classic Hodgkin lymphoma (CHL) is extremely rare. The present study describes a case of CHL in an 11-year-old male presenting with lower back and right hip pain. Radiologic imaging showed a solitary lytic lesion involving the L5 vertebrae and sacrum. Pathologic examination led to a diagnosis of extranodal osseous CHL and further workup proved bone marrow and nodal disease. Diagnosis of extranodal osseous CHL is challenging, especially in this age group and location. When confronted with a solitary lytic bone lesion in a young patient, more common benign and neoplastic entities enter the differential diagnosis and include osteomyelitis, Langerhans cell histiocytosis, epithelioid hemangioma of bone, leukemia, and anaplastic large cell lymphoma (ALCL) among others, with extranodal osseous CHL being one of the less common entities in the differential diagnosis. This case report raises the awareness of extranodal osseous CHL as one of the entities to consider when confronted with a solitary lytic bone lesion in a young patient.
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PMID:Classic Hodgkin lymphoma with initial extranodal osseous presentation: a case report and literature review. 3146 27