Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The primary cerebral lymphoma (non Hodgkin lymphoma) is described as a tumor confined to the central nervous system. They are considered of very low frequency, less tha 1% of the primary tumors of the central nervous system. The up to date treatment is a combination of chemio and radio therapy in patients younger than sixty years old: After this age only radiotheraphy is recommended. We present two cases of primary cerebral lypmhomas, confirmed by the pathology. Both were operated and received steroids and radiotherapy. The first one received treatment in 1992: decadron and limited radiotherapy (1400 rads). He improved clinically and the lesion disappeared. In 1996 he was reoperated because of a recurrence. At this time a resection was performed. The patient received radiotherapy. A year later no recurrence has appeared. The second case was operated on april 1997. He received radiotherapy postoperatively, He developed aphasia and hemiplegia from which recovered completely. Both patients were immuno competent and their prognosis remains uncertain.
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PMID:[Primary lymphoma of the brain. (Report of 2 cases)]. 1099 87

We report on two sibs with ICF syndrome (immunodeficiency, centromeric heterochromatin instability, and facial anomalies) diagnosed in the elder brother based on the typical chromosomal abnormalities present in 56% of metaphases from cultured lymphocytes. In a previous cytogenetic analysis this diagnosis had been missed due to low manifestation of the ICF chromosomal phenotype. Hypomethylation of classical satellites 2 and 3, and of alpha-satellite DNA was shown in the lymphocytes of the younger sister. At 7 years of age the boy presented with hemiplegia due to tumerous invasion of the right brachial plexus. Histopathology revealed classical Hodgkin lymphoma, a neoplasia which might have been facilitated by the underlying genetic defect.
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PMID:ICF syndrome: high variability of the chromosomal phenotype and association with classical Hodgkin lymphoma. 1770 9

A 63-year-old man was admitted to our Oncology department for management of a follicular non-Hodgkin lymphoma, stage IV A FLIPI 5. The patient entered chemotherapy following the R-CHOP schedule, and a PET scan after three cycles showed partial remission. One week later he was admitted to our hospital after developing serious pain in his left arm resulting in an impaired function, right facial hemiplegia, and ophthalmoplegia. Neuroimaging studies and laboratory features were negative. Given his symptoms, we suspected Miller Fisher syndrome and the patient was administered high dose immunoglobulin, but showed no improvement. Finally, chemotherapy with methotrexate 3 g/mq was initiated, but his condition progressively worsened and the patient died 2 months later. We suggest that any patient with neurological symptoms who has received rituximab should undergo PCR analysis for all neurotropic viruses together with neurophysiological and neuroimaging studies.
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PMID:Neurological syndrome after R-CHOP chemotherapy for a non-Hodgkin lymphoma: what is the diagnosis? 2199 75