Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A large number of studies have investigated the relationship between the long-term survival and the percentage of tumor cells in S phase assessed by autoradiography after tritiated thymidine labelling, image cytometry, flow cytometry or labelling with an halogenated analog of thymidine, in various types of human solid tumors. The survey of the results clearly shows that the S-phase fraction (SPF) is of high prognostic significance in several types of cancers, in particular in breast cancers, non-Hodgkin lymphomas, ovarian cancers, neuroblastoma, bladder cancers and lung cancers. SPF was found of high independent significance in 10 of the 11 studies in which multivariate analyses of prognostic factors had been carried out. Proliferation appears generally to be of higher prognostic significance than ploidy. In view of the wide differences in the biological characteristics of the tumors studied, it is likely that the association between a high proliferation rate and the degree of tumor aggressiveness is a general feature of human solid tumors. However, high proliferative rate of tumor cells is probably not the cause of tumor biological aggressiveness but a variable associated with it. The extent to which cells escape from the regulatory systems which control their proliferation appears to be a good index of tumor progression.
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PMID:Cell proliferation kinetics in human solid tumors: relation to probability of metastatic dissemination and long-term survival. 266 9

The appearance of lymphomatous cells in the bone marrow and peripheral blood in 120 patients with Non-Hodgkin's lymphomas (NHLs), was investigated. The presence of lymphomatous cells in the bone marrow was found in 56.6% ob patients and in the peripheral blood in 23.3% of individuals. Lymphomatous site in the bone marrow was proportionally frequent in the group of patients with the high grade aggressive NHLs in comparison to the low grade group. The finding of the peripheral blood occupation was reversible However no significant statistical difference was found. The results also suggest that lymphomatous invasion of the bone marrow does not obligatory predict the invasion of the peripheral blood. Reverse correlation between the frequent bone marrow and peripheral blood occupation by lymphomatous cells and the mean survival time which was significantly shorter in the patients who exhibited the invasion of any kind, was also found. This means that lymphomatous invasion of the bone marrow and peripheral blood might be a potentially useful parameter of the clinical aggressiveness and the course of the disease.
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PMID:[Incidence of lymphoma cells in the bone marrow and peripheral blood in patients with non-Hodgkin's type lymphoma]. 279 47

Mutant clonogenic cells, resistant to individual chemotherapeutic agents, are known to play a central role in clinical chemotherapy failure. The possibility that mutant cells, resistant to conventionally fractionated megavoltage photon radiotherapy, exist in human tumors is considered. Applying the mutation theory of Luria and Delbruck to describe the appearance of resistant cells, several conclusions follow: (a) the mean number of resistant cells in a tumor will be determined by the tumor size and the mutation rate; (b) a wide variation in radiosensitivity in tumors of the same histology is expected, because of a large variation in the number of resistant cells that they contain; (c) the presence of a resistant clone will not reduce the tumor-control probability until the tumor becomes sufficiently large; (d) initial response will not be a reliable predictor of long-term control; (e) clonogenic assays may not accurately predict treatment outcomes; (f) the mutation rate may be the most accurate predictor of tumor aggressiveness and resistance to various treatment modalities; (g) tumors with a low mutation rate, which may include seminoma, Hodgkin's disease and many pediatric tumors would be curable by either chemotherapy or radiation; (h) pleomorphic tumors with a high mutation rate, which may include glioblastoma multiforme, would be difficult to cure by any means. Clinical and experimental evidence is reviewed for the existence of radioresistant cell lines in human and animal tumors, and further experiments are proposed to test this hypothesis. Treatment strategies for targeting radioresistant clones are discussed.
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PMID:Tumor heterogeneity, tumor size, and radioresistance. 280 62

We investigated the expression of adherence molecules lymphocyte function-associated antigens-1 alpha and -beta (LFA-1 alpha, -beta) and p150, 95 in 103 well-characterized non-Hodgkin's lymphomas (NHLs) and lymphoid leukemias (LLs). We found that NHLs and LLs differentially express LFA-1 molecules according to their lineage derivation, degree of clinical aggressiveness, and anatomic site of involvement. Specifically, (a) T-cell neoplasms nearly always express these molecules; (b) diffuse aggressive B-cell NHLs and mature LLs often lack LFA-1 alpha molecules; and (c) B-cell chronic lymphocytic leukemia (CLL) is often LFA-1 alpha-negative while B-cell small lymphocytic lymphomas (SLLs) are nearly always LFA-1 alpha-positive. Furthermore, the low expression of LFA-1 alpha in CLL is related to the low degree of homotypic lymphocyte adhesion after tumor promoter antigen stimulation that does not modulate the expression of LFA-1 alpha in vitro. The differential expression of LFA-1 by B-cell CLL and SLL and their degree of homotypic lymphocyte adhesion may account for the distinct anatomic compartmentalization and characteristic clinical behavior of these two morphologically and immunologically similar lymphoid malignancies.
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PMID:Differential expression of LFA-1 molecules in non-Hodgkin's lymphoma and lymphoid leukemia. 304 46

A review of 40 cases of peripheral T-cell lymphoma identified at our institution between March 1983 and December 1985 revealed a clinically, histologically, and immunologically diverse group of neoplasms that were difficult to classify by conventional histomorphologic criteria for non-Hodgkin's lymphomas. These lymphomas were frequently extranodal at the time of initial manifestation (52%), and their clinical aggressiveness correlated with three major histologic categories--small lymphocytic, diffuse mixed, and large cell. Of the 40 lymphomas, 18 exhibited distinctive histologic features that allowed assignment of these cases into one of four subgroups: (1) angioimmunoblastic lymphadenopathy, (2) lymphomatoid granulomatosis, (3) Hodgkin's-like disease, and (4) Lennert's lymphoma (lymphoepithelioid lymphoma). Study of all our cases that fulfilled the morphologic criteria for lymphomatoid granulomatosis or angioimmunoblastic lymphadenopathy by using immunologic methods for identification of B-cell and T-cell antigens has shown these neoplasms to be peripheral T-cell lymphomas. Therefore, we now consider these earlier proposed entities to be distinct histologic variants of peripheral T-cell lymphoma.
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PMID:Peripheral T-cell lymphomas: histologic, immunohistologic, and clinical characterization. 308 32

The radiological features of bone lesions in patients affected by malignant lymphoma (Hodgkin's lymphoma, non-Hodgkin's lymphoma and primary non-Hodgkin's lymphoma of bone) were studied. For each bone lesion the site and type of alteration, the involvement of the cortex and adjacent soft tissue, the periosteal reaction and the presence of a pathological fracture were considered. The radiological aggressiveness of bone lesions in malignant lymphoma was assessed on the basis of these data according to Lodwick criteria; the lower aggressiveness of bone lesions of Hodgkin's than in non-Hodgkin's lymphoma is stressed.
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PMID:[Comparative radiologic study of bone localizations of malignant lymphomas]. 361 78

The data pertinent to 101 patients with Hodgkin's disease who had been subjected to splenectomy and combined radiation therapy and chemotherapy are analysed. The efficacy of the treatment was relatively dependent on the initial localization and the degree of the generalization and aggressiveness of the disease. Variations in the prognosis at individual stages of the disease may be ascribed to biological differences in the degree of malignancy that may be low moderate or high. The tendency toward limited progress of the disease and successful treatment during clinical stages I and II may be due to slightly impaired local antitumor immunity in the zones of initial malignant induction. Acceleration of the disease gene ralization stemmed from totally deranged antitumor immunity. It should be assumed, in accordance with the recirculation of malignant lymphocytes, that clinical stages I and II are not isolated stages of the disease, since the diaphragm has no barrier ability and there are difficulties in differentiating between stages II and III. The modern therapeutic remedies have reached the peak of their potentialities. This prompt the necessity of the search for new, still unknown biological methods, permitting the attainment of a more complete demalignancy.
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PMID:[Treatment of Hodgkin's disease]. 378 93

Skeletal involvement of non-Hodgkin's lymphoma is found in 11-16%, in Hodgkin's disease in 7.6-34%. Primary lymphoma of bone has an incidence of 1-50% among all non-Hodgkin's lymphoma. The occurrence of skeletal lesions is higher in infants and children than in adults. Skeletal lesions caused by Hodgkin's and non-Hodgkin's lymphoma are mostly seen in the axial skeleton including the skull, whereas the primary lymphoma of bone seems to prefer a more peripheral site. The aggressiveness of the tumor growth can be measured by the method of Lodwick, by judging the edge characteristic, the penetration of the cortex, the periostal and sclerotic reaction. 3 examples illustrate this method. Conventional radiographs need only be performed when there is reason to believe a lesion is located in an area of structural importance, such as the neck of the femur, and in cases of skeletal pain of unknown origin.
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PMID:[Evaluation of bone lesions in malignant lymphomas]. 408 75

T-cell subpopulations have been implicated in the regulation of normal human B-cell reactivity. As the non-Hodgkin lymphomas (NHL) represent predominantly clonal B-cell malignancies, we examined the relationship of total T-cell [Sheep Red Blood Cell (SRBC) binding] and Fc gamma bearing T-cell populations in these disorders. Peripheral blood from seven low-grade (Rai stage 0), six high-grade (Rai stage 3 or 4) CLL patients, lymph node specimens from five patients with WDLL, seven patients with PDLL-D, three patients with MC-D, and eight patients with DHL were studied. All values were compared to normal controls. The percentage of total T cells in each disease category was decreased compared to controls. In addition, there was a reproducible correlation between the percentage of Fc gamma bearing T cells and the histopathologic diagnosis. The percentage of Fc gamma bearing T cells was highest in low-grade CLL and decreased incremently from high-grade CLL and WDLL, to MC-D, and PDLL-D. In DHL, we found no Fc gamma bearing T cells. Finally, the percentage of Fc gamma bearing T cells in each disease category was decreased compared to controls. These findings suggest a correlation between Fc gamma bearing T cells and the clinical aggressiveness of disease in NHL. In addition, they may raise important questions about therapy. Finally, they may offer a useful clinical test as an adjunct to histopathology although this will need to be confirmed in larger series.
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PMID:Fc gamma bearing T cells in non-Hodgkin lymphoma. 623 46

The infections due to herpes-varicella viruses occurring in 191 patients with Hodgkin's disease form the basis of this report. There were overall 41 episodes (26.7%) in 40 patients, distributed as follows: varicella in three cases, atypical herpes-varicella in two cases, and herpes zoster in 36 cases, the latter showing systemic spread in seven instances, one to the central nervous system (myelitis) and six to the skin. The mortality was 2.5% of all infections, and 33% of the varicella cases. Morbidity was apparent as postherpetic neuralgia in seven patients (19.4%), postherpetic paraplegia in one case (2.5%), and severe thrombocytopenia in another case (2.5%). The statistical study of the factors contributing to the development of reactivation episodes demonstrated that neither age, sex, or previous splenectomy were influential. The results obtained in relation to the stage and histologic type of Hodgkin's disease can not be fully evaluated because of the artifact introduced by other variables such as type of therapy and observation time. There was a clear relationship with the aggressiveness of therapy, because 81.7% of the viral episodes occurred in patients submitted to total radiotherapy with or without chemotherapy, or with partial radiotherapy plus chemotherapy. In the patients with systemic spread there was a clear relationship with prior splenectomy (p less than 0.005). The clinical features of these patients are commented upon.
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PMID:[Infections due to herpes-varicella viruses in Hodgkin's disease (author's transl)]. 626 37


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